Uchl1 - ubiquitin carboxy-terminal hydrolase L1 Gene

Also Known as gad; PGP9.5; UCH-L1; UCHL-1; PGP 9.5

Species: Mus musculus

Gene Type: protein coding

Gene ID: 22223

Summary

Enables thiol-dependent Deubiquitinase and ubiquitin binding activity. Involved in cellular response to xenobiotic stimulus. Acts upstream of or within several processes, including adult walking behavior; axon target recognition; and response to ischemia. Located in several cellular components, including axon; neuron projection terminus; and neuronal cell body. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and hereditary spastic paraplegia. Orthologous to human UCHL1 (ubiquitin C-terminal hydrolase L1). [provided by Alliance of Genome Resources, Apr 2022]

Uchl1 Products (1)

mRNA	Protein	Name
NM_011670.2	NP_035800.2	ubiquitin carboxyl-terminal hydrolase isozyme L1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cysteine-type deubiquitinase activity	IDA IDA: Inferred from direct assay	12913066	MGI
enables ribosome binding	IDA IDA: Inferred from direct assay	23064229	MGI
enables ubiquitin binding	IDA IDA: Inferred from direct assay	12913066	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within adult walking behavior	IGI IGI: Inferred from genetic interaction	11555633	MGI
acts upstream of or within adult walking behavior	IMP IMP: Inferred from mutant phenotype	3340629	MGI
acts upstream of or within axon target recognition	IMP IMP: Inferred from mutant phenotype	8474599	MGI
acts upstream of or within axonal transport of mitochondrion	IMP IMP: Inferred from mutant phenotype	2558488	MGI
acts upstream of or within axonogenesis	IMP IMP: Inferred from mutant phenotype	1630580	MGI
involved in cellular response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	23064229	MGI
acts upstream of or within eating behavior	IGI IGI: Inferred from genetic interaction	11555633	MGI
acts upstream of or within male germ cell proliferation	IMP IMP: Inferred from mutant phenotype	12638230	MGI
acts upstream of or within muscle cell development	IGI IGI: Inferred from genetic interaction	8007658	MGI
acts upstream of or within neuromuscular process	IMP IMP: Inferred from mutant phenotype	3340629	MGI
acts upstream of or within response to ischemia	IMP IMP: Inferred from mutant phenotype	14695319	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	8896700	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	12913066	MGI
located in cytosol	IDA IDA: Inferred from direct assay	12913066	MGI
located in neuron projection terminus	IDA IDA: Inferred from direct assay	24760869	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	11549719	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
ubiquitin carboxyl-terminal hydrolase isozyme L1	gracile axonal dystrophy neuron cytoplasmic protein 9.5 protein gene product 9.5 ubiquitin thioesterase L1

Recombinant Uchl1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73466	UCHL1 Protein, Mouse (His)	Q9R0P9 (Q2-A223)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153627	GK13S	Inhibitor	99.09%	Unkown
HY-161378	UCHL1-IN-1	Inhibitor	98.0%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Uchl1	NCBI	NCBI:7345
Rattus norvegicus	Uchl1	NCBI	NCBI:29545