PAN3 - poly(A) specific ribonuclease subunit PAN3 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 255967

About PAN3

Cytogenetic location: 13q12.2 Genomic coordinates (GRCh38): 13:28,138,193-28,295,335 (from NCBI)

This gene has 4 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in bone marrow (RPKM 8.7), spleen (RPKM 8.4) and 25 other tissues.

Summary

Contributes to poly(A)-specific ribonuclease activity. Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening. Predicted to act upstream of or within deadenylation-dependent decapping of nuclear-transcribed mRNA; positive regulation of cytoplasmic mRNA processing body assembly; and protein targeting. Part of PAN complex. [provided by Alliance of Genome Resources, Apr 2022]

PAN3 Products (1)

mRNA	Protein	Name
NM_175854.8	NP_787050.6	PAN2-PAN3 deadenylation complex subunit PAN3

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to poly(A)-specific ribonuclease activity	IDA IDA: Inferred from direct assay	14583602	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14583602	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of PAN complex	IDA IDA: Inferred from direct assay	14583602	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
PAN2-PAN3 deadenylation complex subunit PAN3	PAB-dependent poly(A)-specific ribonuclease subunit 3

PAN3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PAN3	Q58A45	PAN2	Homo sapiens	Q504Q3	Anti Tag CoIP	33961781
Intra	PAN3	Q58A45	PAN2	Homo sapiens	Q504Q3	Anti Tag CoIP	14583602
Intra	PAN3	Q58A45	PAN2	Homo sapiens	Q504Q3	Confocal	14583602
Intra	PAN3	Q58A45	TNRC6A	Homo sapiens	Q8NDV7	Anti Tag CoIP	21981923
Intra	PAN3	Q58A45	TNRC6C	Homo sapiens	Q9HCJ0	Anti Tag CoIP	21981923
Intra	PAN3	Q58A45	PABPC1	Homo sapiens	P11940	ITC	17595167
Intra	PAN3	Q58A45	PABPC1	Homo sapiens	P11940	Anti Tag CoIP	23340509
Intra	PAN3	Q58A45	TNRC6B	Homo sapiens	Q9UPQ9	Anti Tag CoIP	21981923

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Balanoposthitis	Balanitis Due To Infection

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09362	NLRP6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10015	PAN3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18148	Pan3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24623	Pan3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PAN3	VGNC	VGNC:102279
Mus musculus	PAN3	MGD	MGI:1919837
Macaca mulatta	PAN3	VGNC	VGNC:106281
Bos taurus	PAN3	VGNC	VGNC:53830
Canis familiaris	PAN3	VGNC	VGNC:59088
Rattus norvegicus	PAN3	RGD	RGD:1590880
Others	PAN3	NCBI