PAN2 - poly(A) specific ribonuclease subunit PAN2 Gene

Also Known as USP52

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9924

About PAN2

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:56,316,936-56,334,000 (from NCBI)

This gene has 21 transcripts (splice variants) and 223 orthologues. Ubiquitous expression in testis (RPKM 19.6), thyroid (RPKM 18.6) and 25 other tissues.

Summary

This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

PAN2 Products (13)

mRNA Protein Name
NM_001127460.4 NP_001120932.2 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 1
NM_001166279.3 NP_001159751.2 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 2
NM_001394699.1 NP_001381628.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 1
NM_001394700.1 NP_001381629.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 3
NM_001394701.1 NP_001381630.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 4
NM_001394702.1 NP_001381631.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 4
NM_001394703.1 NP_001381632.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 5
NM_001394704.1 NP_001381633.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 6
NM_001394705.1 NP_001381634.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 7
NM_001394706.1 NP_001381635.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 8
NM_001394707.1 NP_001381636.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 8
NM_001394708.1 NP_001381637.1 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 9
NM_014871.6 NP_055686.4 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform 3

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 3'-5'-RNA exonuclease activity IDA
IDA: Inferred from direct assay
14583602 GOA
enables poly(A)-specific ribonuclease activity IDA
IDA: Inferred from direct assay
14583602 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14583602 GOA
Cellular Component GO Annotation Evidence References Source
part of PAN complex IDA
IDA: Inferred from direct assay
14583602 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PAN2 Protein Structure

UCH_1

UCH_1: Ubiquitin carboxyl-terminal hydrolase (517 - 898)

RNase_T

RNase_T: Exonuclease (975 - 1147)

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  • 1000
  • 1202 a.a.
Protein Preferred Names Protein Names

PAN2-PAN3 deadenylation complex catalytic subunit PAN2

  • PAB-dependent poly(A)-specific ribonuclease subunit 2

PAN2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PAN2 Q504Q3 PAN3 Homo sapiens Q58A45
Anti Tag CoIP
14583602
Intra
PAN2 Q504Q3 PAN3 Homo sapiens Q58A45
Anti Tag CoIP
19615732
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09360 NLRP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10014 PAN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17294 Pan2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18501 Tcf3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23749 Pan2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24983 Tcf3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PAN2 MGD MGI:1918984
Bos taurus PAN2 VGNC VGNC:58444
Macaca mulatta PAN2 VGNC VGNC:100085
Rattus norvegicus PAN2 RGD RGD:1303301
Canis familiaris PAN2 VGNC VGNC:54530
Others PAN2 NCBI