GSN - gelsolin Gene

Also Known as ADF; AGEL

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2934

About GSN

Cytogenetic location: 9q33.2 Genomic coordinates (GRCh38): 9:121,201,483-121,332,842 (from NCBI)

This gene has 16 transcripts (splice variants), 271 orthologues, 7 paralogues and is associated with 3 phenotypes. Broad expression in fat (RPKM 444.2), heart (RPKM 172.6) and 23 other tissues.

Summary

The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GSN Products (36)

mRNA	Protein	Name
NM_000177.5	NP_000168.1	gelsolin isoform a precursor
NM_001127662.2	NP_001121134.1	gelsolin isoform b
NM_001127663.2	NP_001121135.2	gelsolin isoform f
NM_001127664.2	NP_001121136.1	gelsolin isoform b
NM_001127665.2	NP_001121137.1	gelsolin isoform b
NM_001127666.2	NP_001121138.1	gelsolin isoform c
NM_001127667.2	NP_001121139.1	gelsolin isoform c
NM_001258029.2	NP_001244958.1	gelsolin isoform d
NM_001258030.2	NP_001244959.1	gelsolin isoform e
NM_001353053.1	NP_001339982.1	gelsolin isoform b
NM_001353054.1	NP_001339983.1	gelsolin isoform b
NM_001353055.2	NP_001339984.1	gelsolin isoform b
NM_001353056.2	NP_001339985.1	gelsolin isoform b
NM_001353057.2	NP_001339986.1	gelsolin isoform b
NM_001353058.2	NP_001339987.1	gelsolin isoform b
NM_001353059.2	NP_001339988.1	gelsolin isoform b
NM_001353060.2	NP_001339989.1	gelsolin isoform b
NM_001353061.2	NP_001339990.1	gelsolin isoform b
NM_001353062.1	NP_001339991.1	gelsolin isoform b
NM_001353063.2	NP_001339992.1	gelsolin isoform c
NM_001353064.2	NP_001339993.1	gelsolin isoform c
NM_001353065.2	NP_001339994.1	gelsolin isoform c
NM_001353066.2	NP_001339995.1	gelsolin isoform c
NM_001353067.2	NP_001339996.1	gelsolin isoform c
NM_001353068.2	NP_001339997.1	gelsolin isoform c
NM_001353069.2	NP_001339998.1	gelsolin isoform c
NM_001353070.2	NP_001339999.1	gelsolin isoform c
NM_001353071.2	NP_001340000.1	gelsolin isoform c
NM_001353072.2	NP_001340001.1	gelsolin isoform c
NM_001353073.2	NP_001340002.1	gelsolin isoform c
NM_001353074.2	NP_001340003.1	gelsolin isoform c
NM_001353075.1	NP_001340004.1	gelsolin isoform c
NM_001353076.2	NP_001340005.1	gelsolin isoform g
NM_001353077.1	NP_001340006.1	gelsolin isoform c
NM_001353078.2	NP_001340007.1	gelsolin isoform h
NM_198252.3	NP_937895.1	gelsolin isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables actin binding	IDA IDA: Inferred from direct assay	18266911	GOA
enables calcium ion binding	IMP IMP: Inferred from mutant phenotype	14596804	GOA
enables myosin II binding	IPI IPI: Inferred from physical interaction	23325791	GOA
enables phosphatidylinositol 3-kinase catalytic subunit binding	IPI IPI: Inferred from physical interaction	30568254	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10793131	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in actin filament capping	IMP IMP: Inferred from mutant phenotype	19666531	GOA
involved in actin filament depolymerization	IDA IDA: Inferred from direct assay	30568254	GOA
involved in actin filament organization	IGI IGI: Inferred from genetic interaction	23575248	GOA
involved in actin filament polymerization	IDA IDA: Inferred from direct assay	3020431	GOA
involved in actin filament polymerization	IMP IMP: Inferred from mutant phenotype	23729654	GOA
involved in actin filament severing	IDA IDA: Inferred from direct assay	3020431	GOA
involved in actin filament severing	IMP IMP: Inferred from mutant phenotype	23575248	GOA
involved in amyloid fibril formation	IMP IMP: Inferred from mutant phenotype	19904968	GOA
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	20393563	GOA
NOT involved in extracellular matrix disassembly	IMP IMP: Inferred from mutant phenotype	24236012	GOA
involved in hepatocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	22952982	GOA
involved in negative regulation of viral entry into host cell	IMP IMP: Inferred from mutant phenotype	23575248	GOA
involved in positive regulation of actin nucleation	IMP IMP: Inferred from mutant phenotype	19666531	GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	22952982	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22952982	GOA
involved in positive regulation of keratinocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	23729654	GOA
involved in protein destabilization	IMP IMP: Inferred from mutant phenotype	19549824	GOA
involved in regulation of establishment of T cell polarity	IMP IMP: Inferred from mutant phenotype	23575248	GOA
involved in regulation of plasma membrane raft polarization	IMP IMP: Inferred from mutant phenotype	23575248	GOA
involved in regulation of podosome assembly	IMP IMP: Inferred from mutant phenotype	24236012	GOA
involved in regulation of receptor clustering	IMP IMP: Inferred from mutant phenotype	23575248	GOA
involved in renal protein absorption	IMP IMP: Inferred from mutant phenotype	24601799	GOA
involved in sequestering of actin monomers	IMP IMP: Inferred from mutant phenotype	19666531	GOA
involved in striated muscle atrophy	IMP IMP: Inferred from mutant phenotype	19549824	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in actin cap	IDA IDA: Inferred from direct assay	23575248	GOA
colocalizes with cortical actin cytoskeleton	IDA IDA: Inferred from direct assay	23575248	GOA
located in cortical actin cytoskeleton	IDA IDA: Inferred from direct assay	24236012	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	23575248	GOA
located in cytosol	IDA IDA: Inferred from direct assay	3020431	GOA
located in extracellular region	IDA IDA: Inferred from direct assay	3020431	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	14596804	GOA
colocalizes with nucleus	IDA IDA: Inferred from direct assay	23729654	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	23575248	GOA
located in podosome	IDA IDA: Inferred from direct assay	24236012	GOA
located in sarcoplasm	IDA IDA: Inferred from direct assay	19549824	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GSN Protein Structure

Gelsolin

0
200
400
600
782 a.a.

Protein Preferred Names	Protein Names
gelsolin	actin-depolymerizing factor

GSN Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GSN	P06396	DISC1	Homo sapiens	Q9NRI5	Anti Tag CoIP	29961565
Cross	GSN	P06396	ACTA1	Oryctolagus cuniculus	P68135	X-Ray Diffraction	19666512
Cross	GSN	P06396	ACTA1	Oryctolagus cuniculus	P68135	GMS	19666512
Cross	GSN	P06396	ACTA1	Oryctolagus cuniculus	P68135	IF	19666512
Cross	GSN	P06396	ACTA1	Oryctolagus cuniculus	P68135	Far-WB	16531231
Cross	GSN	P06396	ACTA1	Oryctolagus cuniculus	P68135	Polymerization	19666512

Cross: Cross-species interaction Intra: Intraspecies interaction

GSN Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81825	Gelsolin Antibody (YA1570)	WB, IHC-P, ICC/IF, FC	Human, Mouse
HY-P83971	Gelsolin Antibody (YA3668)	IHC-P, FC, ELISA	Human
HY-P83971A	Gelsolin Antibody (YA3668)(PBS only)	IHC-P, FC, ELISA	Human

Related Diseases

Diseases	Alias
Amyloidosis, Finnish Type	Finnish Type Amyloidosis Meretoja Syndrome Amyloidosis V Amyloidosis, Meretoja Type Amyloid Cranial Neuropathy With Lattice Corneal Dystrophy Lattice Corneal Dystrophy Type Ii Familial Amyloidosis, Finnish Type Familial Amyloid Polyneuropathy Type Iv Amyloidosis Due To Mutant Gelsolin Agel Amyloidosis Gelsolin Amyloidosis Hereditary Gelsolin Amyloidosis Lattice Corneal Dystrophy Type Ii Finnish Gelsolin-Related Amyloidosis Kymenlaakso Syndrome Lattice Corneal Dystrophy, Gelsolin Type Hereditary Amyloidosis, Finnish Type Lattice Corneal Dystrophy Type 2 Amyloidosis 5 AMYL5 Agel Familial Amyloidosis Finnish Type Meretoja Type Amyloidosis Type Iv Familial Amyloid Polyneuropathy Familial Amyloid Polyneuropathy, Type V Familial Amyloid Polyneuropathy, Type Iv
Amyloidosis	Amyloid Disease Amyloid Amyloid Degeneration Amyloidosis Nos Amyloid Deposition Amyloid Infiltration Idiopathic Amyloidosis Hyaloid Degeneration Lardaceous Degeneration
Lattice Corneal Dystrophy	Familial Amyloid Neuropathy, Finnish Type Familial Amyloid Polyneuropathy, Type V
Hereditary Amyloidosis	Amyloidosis Hereditary Familial Amyloidosis Amyloidosis Familial Amyloidosis, Hereditary Amyloidosis, Familial Genetic Amyloidosis Heredofamilial Amyloidosis
Amyloidosis, Hereditary, Transthyretin-Related	Transthyretin Amyloidosis Familial Amyloid Polyneuropathy Ttr Amyloid Neuropathy Transthyretin Amyloid Neuropathy Transthyretin Amyloid Polyneuropathy Fap Familial Transthyretin Amyloidosis Amyloidosis Transthyretin Related Type I Familial Amyloid Polyneuropathy Familial Amyloid Polyneuropathy Type I Attrv122i Amyloidosis Hereditary Amyloidosis, Transthyretin-Related Amyloid Polyneuropathy, Familial Attr Amyloidosis Attrm Amyloidosis Corino De Andrade'S Disease Paramyloidosis Transthyretin-Related Hereditary Amyloidosis Ttr Amyloidosis Hereditary Attr Amyloidosis Portuguese Polyneuritic Amyloidosis Portuguese Type Familial Amyloid Neuropathy Swiss Type Amyloid Polyneuropathy Type Ii Familial Amyloid Polyneuropathy Attrv30m Amyloidosis Attrv30m-Related Amyloidosis Familial Amyloid Polyneuropathy, Portuguese-Swedish-Japanese Type Attr Cardiomyopathy Attrv122i-Related Amyloidosis Ttr-Related Amyloid Cardiomyopathy Ttr-Related Cardiac Amyloidosis Transthyretin Amyloid Cardiopathy Transthyretin-Related Familial Amyloid Cardiomyopathy Amyloidosis, Transthyretin-Related AMYL-TTR Amyloidosis I Amyloidosis Ohio Type Amyloidosis Type 7 Amyloidosis Vii Amyloid Polyneuropathy Attr Familial Amyloid Polyneuropathy Type Ii Hereditary Amyloidosis Transthyretin-Related Leptomeningeal Amyloidosis Meningocerebrovascular Amyloidosis Oculoleptomeningeal Amyloidosis Familial Amyloid Polyneuropathies Amyloidosis, Leptomeningeal Senile Cardiac Amyloidosis Amyloid Neuropathies, Familial Danish Type Familial Amyloid Cardiomyopathy Familial Amyloid Neuropathy, Portuguese Type Amyloid Polyneuropathy, Swiss Type Hereditary Oculoleptomeningeal Amyloid Angiopathy Amyloid Neuropathies
Polyneuropathy	Polyneuropathies
Corneal Dystrophy, Gelatinous Drop-Like	Gelatinous Drop-Like Corneal Dystrophy GDLD Cdgdl Corneal Amyloidosis Lattice Corneal Dystrophy Type Iii Amyloidosis, Corneal Amyloid Corneal Dystrophy, Japanese Type Gdcd Primary Familial Amyloidosis Of The Cornea Subepithelial Amyloidosis Of The Cornea Corneal Dystrophy, Lattice Type 3 Corneal Dystrophy, Lattice Type Iii Lattice Corneal Dystrophy, Type Iii Amyloidosis Corneal Lattice Corneal Dystrophy Type3 Amyloid Corneal Dystrophy Japanese Type Dystrophy, Corneal, Gelatinous Drop-Like Amyloid Of Cornea
Corneal Dystrophy
Amyloid Neuropathy	Amyloid Neuropathies Neuropathy Amyloid
Corneal Dystrophy, Lattice Type I	Lattice Corneal Dystrophy Type I Lcd1 CDL1 Lcd Lattice Corneal Dystrophy Type 1 Corneal Dystrophy, Lattice Type 1 Biber-Haab-Dimmer Dystrophy Lattice Corneal Dystrophy, Type I Classic Lattice Corneal Dystrophy Lcdi Corneal Dystrophy Lattice Type I Dystrophy, Corneal, Lattice Type I
Primary Cutaneous Amyloidosis	Plca Primary Localized Cutaneous Amyloidosis Familial Primary Localized Cutaneous Amyloidosis Amyloidosis Ix Lichen Amyloidosis Familial Amyloidosis, Primary Cutaneous Pca Amyloidosis 9 Amyloidosis Familial Cutaneous Lichen Fplca Familial Lichen Amyloidosis
Amyloidosis, Familial Visceral	Ostertag Type Amyloidosis German Type Amyloidosis Familial Renal Amyloidosis Amyloidosis Viii Amyloidosis, 3 Or More Types Familial Visceral Amyloidosis Familial Amyloid Nephropathy Hereditary Amyloid Nephropathy Amyloidosis, Familial Renal Amyloidosis, Systemic Nonneuropathic Amyloidosis Familial Visceral Amyloidosis 8 Amyloidosis, Ostertag Type Hereditary Amyloidosis With Primary Renal Involvement Hereditary Renal Amyloidosis Renal Amyloidosis Amyloidosis, Renal Systemic Nonneuropathic Amyloidosis Amyloidosis Familial Renal Amyloidosis Systemic Nonneuropathic Hereditary Amyloidosis With Primary Renal Involement AMYL8 Systemic Non-Neuropathic Amyloidosis Amyloid Nephropathy
Cerebral Amyloid Angiopathy, Cst3-Related	Cerebral Amyloid Angiopathy Hereditary Cerebral Hemorrhage With Amyloidosis Hchwa Hereditary Cystatin C Amyloid Angiopathy Cerebral Amyloid Angiopathy, Familial Amyloidosis, Cerebroarterial, Icelandic Type Amyloidosis Vi Cerebral Hemorrhage, Hereditary, With Amyloidosis Cst3-Related Cerebral Amyloid Angiopathy Cerebral Hemorrhage, Hereditary, With Amyloidosis, Icelandic Variant Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Variant Caa, Familial Cerebral Amyloid Angiopathy, Genetic Acys Amyloidosis Cst3-Related Amyloidosis Cystatin Amyloidosis Hchwa, Icelandic Type Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Type Amyloidosis 6 AMYL6 Acys Caa Cerebral Amyloid Angiopathy Cst3-Related Cerebroarterial Amyloidosis Icelandic Type Cystatin C Amyloidosis Hccaa Hchwai Hchwa-I Hereditary Cerebral Hemorrhage With Amyloidosis Icelandic Type Cerebral Amyloid Angiopathy Familial Angiopathy, Amyloid, Cerebral, Cst3-Related Hereditary Cerebral Amyloid Angiopathy, Icelandic Type Familial Cerebral Amyloid Angiopathy Cerebral Amyloid Angiopathy, Hereditary
Corneal Disease	Corneal Diseases Corneal Disorders
Cutis Laxa	Generalized Elastolysis Loose Skin Dermatolysis Dermatomegaly Cutis Laxa Syndrome
Keratoconus	Kc Conical Cornea Noninflammatory Corneal Thining Bulging Cornea Cornea Conical Acquired Conus Of Cornea
Radial Neuropathy
Immunoglobulin Heavy Chain Amyloidosis	Ah Amyloidosis Heavy Chain Amyloidosis Amyloidosis Derived From Immunoglobulin Heavy Chain Ig Heavy-Chain-Associated Amyloidosis
Blepharochalasis	Dermatolysis Palpebrarum Adiposa Ptosis
Nephrotic Syndrome	Finnish Congenital Nephrotic Syndrome Ns - [Nephrotic Syndrome] Nephrosis Syndrome Nephrosis Nos Glomerular Lesion Nephrosis
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Apolipoprotein A-Iv Associated Amyloidosis	Aapoaiv Amyloidosis Renal Aapoaiv Amyloidosis Apolipoprotein A-Iv Amyloidosis
Rheumatic Myocarditis	Acute Rheumatic Myocarditis Active Rheumatic Fever With Myocarditis Acute Rheumatic Carditis Rheumatic Degeneration Of Myocardium Rheumatic Fever With Myocarditis Rheumatoid Myocarditis Acute Rheumatic Heart Disease Acute Rheumatic Fever With Myocarditis Active Or Acute Rheumatic Myocarditis Active Rheumatic Myocarditis Active Rheumatic Progressive Myocarditis Chronic Active Rheumatic Myocarditis Old Active Rheumatic Myocarditis Active Rheumatic Fibroid Myocarditis Active Rheumatic Interstitial Myocarditis Acute Or Subacute Rheumatic Myocardial Insufficiency Acute Rheumatic Toxic Myocarditis Inactive Or Quiescent Rheumatic Fever With Myocarditis Inactive Rheumatic Myocarditis Rheumatic Progressive Myocarditis Rheumatic Fibroid Myocarditis Rheumatic Interstitial Myocarditis Myocardial Degeneration With Rheumatic Fever Myocardial Insufficiency With Rheumatic Fever Rheumatic Cardiomyopathy Dilated Cardiomyopathy Due To Rheumatic Fever Myocarditis Due To Rheumatic Fever Rheumatic Myocardial Insufficiency
Tuberous Sclerosis	Tuberous Sclerosis Syndrome Bourneville'S Disease Epiloia Cerebral Sclerosis Tuberose Sclerosis Tuberous Sclerosis 1 Bourneville Disease Bourneville Phakomatosis Pringle'S Disease
Epithelial-Stromal Tgfbi Dystrophy
Wild-Type Amyloidosis	Senile Systemic Amyloidosis Attrwt Amyloidosis Age Related Amyloidosis Old Age Amyloidosis Wild-Type Attr Amyloidosis Wild-Type Transthyretin Cardiac Amyloidosis Wild Type Attr Amyloidosis Attrwt-Related Amyloidosis Wild Type Attr-Related Amyloidosis
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Cerebral Amyloid Angiopathy, App-Related	Hchwad Amyloidosis, Cerebroarterial, App-Related Amyloidosis, Hereditary, With Cerebral Hemorrhage, Dutch Variant Cerebral Amyloid Angiopathy, App-Related, Dutch Variant Cerebral Amyloid Angiopathy, App-Related, Iowa Variant Cerebral Amyloid Angiopathy, App-Related, Italian Variant Cerebral Amyloid Angiopathy, App-Related, Flemish Variant Cerebral Amyloid Angiopathy, App-Related, Arctic Variant Cerebral Amyloid Angiopathy, Dutch, Italian, Iowa, Flemish, Arctic Variants App-Related Cerebral Amyloid Angiopathy Abetaa21g Amyloidosis Abeta Amyloidosis, Italian Type Abeta Amyloidosis, Arctic Type Abeta Amyloidosis, Iowa Type Abeta Amyloidosis, Dutch Type Hchwa-D Abeta Amyloidosis, Flemish Type Abetaa21g-Related Amyloidosis Hchwa, Flemish Type Hereditary Cerebral Hemorrhage With Amyloidosis, Flemish Type Abetae22k Amyloidosis Hchwa, Italian Type Hereditary Cerebral Hemorrhage With Amyloidosis, Italian Type Abetae22g Amyloidosis Hchwa, Arctic Type Hereditary Cerebral Hemorrhage With Amyloidosis, Arctic Type Abetad23n Amyloidosis Hchwa, Iowa Type Hereditary Cerebral Hemorrhage With Amyloidosis, Iowa Type Abetal34v Amyloidosis Abeta Amyloidosis, Piedmont Type Abetal34v-Related Amyloidosis Hchwa, Piedmont Type Hereditary Cerebral Hemorrhage With Amyloidosis, Piedmont Type Abetae22q Amyloidosis Hchwa, Dutch Type Hereditary Cerebral Hemorrhage With Amyloidosis, Dutch Type CAA-APP Amyloidosis Cerebroarterial App-Related Amyloidosis Hereditary With Cerebral Hemorrhage Dutch Variant Cerebral Amyloid Angiopathy App-Related Arctic Variant Cerebral Amyloid Angiopathy App-Related Dutch Variant Cerebral Amyloid Angiopathy App-Related Flemish Variant Cerebral Amyloid Angiopathy App-Related Iowa Variant Cerebral Amyloid Angiopathy App-Related Italian Variant Familial Occipital Calcifications With Hemorrhagic Strokes Leukoencephalopathy Arterial Dysplasia Dementia Fochs-Ladd Hereditary Cerebral Amyloid Angiopathy Dutch Type Hereditary Cerebral Hemorrhage With Amyloidosis Dutch Type Hereditary Cerebral Hemorrhage With Amyloidosis Italian Type Cerebral Hemorrhage With Amyloidosis, Hereditary, Dutch Type
Immunoglobulin Light Chain Amyloidosis	Al Amyloidosis Primary Amyloidosis Primary Systemic Amyloidosis Light Chain Amyloidosis Amyloidosis Al Amyloidosis Primary Systemic Primary Al Amyloidosis Primary Systemic Al Amyloidosis Systemic Al Amyloidsis Systemic Al Amyloidosis Light-Chain Amyloidosis Alys Amyloidosis Familial Amyloid Nephropathy Due To Lysozyme Variant Familial Renal Amyloidosis Due To Lysozyme Variant Hereditary Amyloid Nephropathy Due To Lysozyme Variant Hereditary Renal Amyloidosis Due To Lysozyme Variant Lysozyme Amyloidosis Amyloidosis Primary Immunoglobulin Deposition Disease Immunoglobulinic Amyloidosis Amyloid Al
Recurrent Corneal Erosion	Recurrent Erosion Of Cornea Recurrent Erosion Syndrome Corneal Erosion Non-Traumatic Recurrent Erosion Of Cornea
Asymmetric Motor Neuropathy
Cerebral Amyloid Angiopathy, Itm2b-Related, 1	Dementia, Familial British Fbd Presenile Dementia With Spastic Ataxia Familial British Dementia Abri Amyloidosis Cerebral Amyloid Angiopathy, British Type Itm2b-Related Cerebral Amyloid Angiopathy 1 Familial Dementia, British Type Cerebral Amyloid Angiopathy, Itm2b-Related 1 CAA-ITM2B1 Cerebral Amyloid Angiopathy British Type Dementia, Familial, British
Epithelial And Subepithelial Dystrophy
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Nerve Compression Syndrome	Entrapment Neuropathies Compression Neuropathy Entrapment Neuropathy Peripheral Nerve Entrapment Syndrome Nerve Compression Syndromes Hereditary Liability To Pressure Palsies
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Myopathy	Muscular Diseases Myopathies
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To Cryptogenic Fibrosing Alveolitis ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-133870	Itaconate-alkyne		98.01%	Unkown
HY-RS18449	Gsn Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05867	GSN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24931	Gsn Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GSN	VGNC	VGNC:29680
Rattus norvegicus	GSN	RGD	RGD:1303089
Canis familiaris	GSN	VGNC	VGNC:41532
Macaca mulatta	GSN	VGNC	VGNC:73299
Mus musculus	GSN	MGD	MGI:95851
Felis catus	GSN	VGNC	VGNC:67486
Others	GSN	NCBI