Gelsolin Antibody (YA3668)
(Synonyms: ADF; AGEL)Gelsolin Antibody (YA3668) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Gelsolin.
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Host:
Mouse
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Isotype:
IgG
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Application:
IHC-P, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
Gelsolin Antibody (YA3668) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Gelsolin.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 86 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 86 kDa
Purified recombinant fragment of human GSN (AA: (673-783)) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Gelsolin is a Ca2+-dependent actin-binding protein that plays a crucial role in processes such as cytoskeleton remodeling and cell migration. Under the regulation of calcium ions, Gelsolin can sever and cap actin filaments, regulate the assembly and disassembly of actin filaments, and remodel the cytoskeleton. Gelsolin is also involved in cell movement, affecting the migration of fibroblasts and the phagocytosis of immune cells, and can regulate the growth cones and filopodia of neurons. In addition, as a downstream effector molecule of Rac, Gelsolin can be dissociated upon activation by Rac, promoting actin remodeling and influencing cellular physiological activities. Mutant mice lacking Gelsolin and clinical studies have shown that Gelsolin is associated with a number of conditions such as inflammation, cancer, and amyloidosis[1].
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Subcellular Localization
Cytoplasm, cytoskeleton; Secreted
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Expression
Tissue_specificity:Phagocytes, platelets, fibroblasts, non-muscle cells, smooth muscle cells, and skeletal muscle cells -
Isoforms & Post-Translational Modification
P06396 has 4 isomers: P06396-1: 85698 Da (predicted); P06396-2: 80641 Da (predicted); P06396-3: 81941 Da (predicted); P06396-4: 81485 Da (predicted).
Phosphorylation on Tyr-86, Tyr-409, Tyr-465, Tyr-603 and Tyr-651 in vitro is induced in presence of phospholipids -
Subunit
Binds to actin and to fibronectin. Identified in a complex composed of ACTA1, COBL, GSN and TMSB4X.
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SwissProt ID
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Synonyms
ADF; AGEL
Documentation
References
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