Mca-Ala-Pro-Lys(Dnp)-OH
Based on 2 publication(s) in Google Scholar
Mca-Ala-Pro-Lys(Dnp)-OH, a specific ACE2 quenched fluorogenic substrate, can be used to detect ACE2 activity, such as urinary, heart and lung.
For research use only. We do not sell to patients.
- Purity: 99.95%
- CAS No.: 305336-82-7
- Formula: C32H36N6O12
- Molecular Weight:696.66
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Mca-Ala-Pro-Lys(Dnp)-OH
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Biological Activity
The activity of ACE2 enzyme detected by: the fluorescent peptide substrate Mca-AlaPro-Lys (Dnp)-OH is hydrolyzed by ACE2 and its product is detected by the active fluorescence resonance energy transfer method[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Mca-AP{K(Dnp)}
Chemical Information
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CAS No. 305336-82-7
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Appearance Solid
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Molecular Weight 696.66
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Formula C32H36N6O12
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Color Yellow to orange
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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iScience
Carfilzomib-specific proteasome β5/β2 inhibition drives cardiotoxicity via remodeling of protein homeostasis and the renin-angiotensin-system. [Abstract]2025 Jul 29;28(9):113228. PMID: 40894880
Solvent & Solubility
DMSO : 50 mg/mL (71.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Liu J, Ji H, et al. Sex differences in renal angiotensin converting enzyme 2 (ACE2) activity are 17β-oestradiol-dependent and sex chromosome-independent. Biol Sex Differ. 2010;1(1):6. Published 2010 Nov 5. [Content Brief]
[2]. Liang Y, et al. Urinary angiotensin converting enzyme 2 increases in patients with type 2 diabetic mellitus. Kidney Blood Press Res. 2015;40(2):101-110. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4354 mL | 7.1771 mL | 14.3542 mL | 35.8855 mL |
| 5 mM | 0.2871 mL | 1.4354 mL | 2.8708 mL | 7.1771 mL | |
| 10 mM | 0.1435 mL | 0.7177 mL | 1.4354 mL | 3.5886 mL | |
| 15 mM | 0.0957 mL | 0.4785 mL | 0.9569 mL | 2.3924 mL | |
| 20 mM | 0.0718 mL | 0.3589 mL | 0.7177 mL | 1.7943 mL | |
| 25 mM | 0.0574 mL | 0.2871 mL | 0.5742 mL | 1.4354 mL | |
| 30 mM | 0.0478 mL | 0.2392 mL | 0.4785 mL | 1.1962 mL | |
| 40 mM | 0.0359 mL | 0.1794 mL | 0.3589 mL | 0.8971 mL | |
| 50 mM | 0.0287 mL | 0.1435 mL | 0.2871 mL | 0.7177 mL | |
| 60 mM | 0.0239 mL | 0.1196 mL | 0.2392 mL | 0.5981 mL |
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