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製品番号: HY-181939

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Antibacterial agent 329

Antibacterial agent 329 (Compound 9c) is an antibacterial agent. Antibacterial agent 329 inhibits the activity of MraY. Antibacterial agent 329 exhibits antibacterial activity against Escherichia coli K12 and Bacillus subtilis W23 with a MIC of 16 μg/mL, but shows no activity against Pseudomonas fluorescens Pf-5. Antibacterial agent 329 exerts antibacterial activity against Acinetobacter baumannii 19606, Staphylococcus aureus MRSA USA300 JE2, Enterobacter cloacae 19434, Klebsiella pneumoniae 700603 and Enterococcus faecium 19434, with MIC values of 8, 8, 16-32, 16-32 and 16 μg/mL, respectively, while it shows no activity against Pseudomonas aeruginosa NCTC 13437.

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分子式: C₁₇H₁₄F₃N₃O
分子量:333.31

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antibacterial agent 329 構造式

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Sample (0.1mg)

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製品説明

体外実験

Antibacterial agent 329 exhibits antimicrobial activity against Escherichia coli K12 and Bacillus subtilis W23 with an MIC of 16 μg/mL, and no activity against Pseudomonas fluorescens Pf-5^[1].
Antibacterial agent 329 exhibits antimicrobial activity against Acinetobacter baumannii 19606, Staphylococcus aureus MRSA USA300 JE2, Enterobacter cloacae 19434, Klebsiella pneumoniae 700603, and Enterococcus faecium 19434 with MIC values of 8, 8, 16-32, 16-32, and 16 μg/mL respectively, and no activity against Pseudomonas aeruginosa NCTC 13437^[1].
Antibacterial agent 329 (200 μM) inhibits particulate Escherichia coli MraY activity by 33%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

分子量 333.31
分子式 C₁₇H₁₄F₃N₃O
SMILES

NC1=NC=C(N1)C2=CC=CC=C2OCC3=CC=C(C(F)(F)F)C=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Murphy R, et al. 4-Aryl-2-aminoimidazole analogues of bromoageliferin with antimicrobial activity against Acinetobacter baumannii show in vitro inhibition of translocase MraY on the peptidoglycan biosynthesis pathway. Bioorg Med Chem Lett. Published online February 24, 2026. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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参考文献

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