Biotin-epoxomicin
Based on 1 Customer Validation
Biotin-epoxomicin is a Proteasome subunit binder. Biotin-epoxomicin serves as an affinity reagent for identifying proteasomal catalytic subunits, and facilitates affinity purification of active proteasomal subunits for LC-MS identification. Biotin-epoxomicin can be used to study solid tumors derived from B16 melanoma.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 95.30%
- CAS 番号: 1334608-28-4
- 分子式: C35H60N6O8S
- 分子量:724.95
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Metabolism/Protease Compound Library
HY-L012
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Anti-Cancer Compound Library
HY-L025
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Ubiquitination Compound Library
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HY-L001V
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HY-L105S
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生物活性
Biotin-epoxomicin (10 μM; 1 hr) covalently binds to the catalytically active β5t subunit in young and adult murine thymus homogenates, enabling affinity purification and definitive LC-MS3 identification of the β5t active-site peptide[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Biotin-IIT-{Leu((2R)-2-methyloxiranyl)}
Biotin-Ile-Ile-Thr-{Leu((2R)-2-methyloxiranyl)}
化学情報
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CAS 番号 1334608-28-4
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性状 Solid
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分子量 724.95
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分子式 C35H60N6O8S
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Color White to off-white
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
純度とドキュメンテーション
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データシート (268 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Portuguese - PT (254 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Sin N, et al. Total synthesis of the potent proteasome inhibitor epoxomicin: a useful tool for understanding proteasome biology. Bioorg Med Chem Lett. 1999;9(15):2283-2288. [Content Brief]
[2]. Florea BI, et al. Activity-based profiling reveals reactivity of the murine thymoproteasome-specific subunit beta5t. Chem Biol. 2010;17(8):795-801. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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