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製品番号: HY-161257

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CDC20-IN-1

CDC20-IN-1 (Compound E1) is a specific inhibitor of CDC20 and can be used in triple-negative breast cancer research. CDC20-IN-1 can induce autophagy in cancer cells and inhibit MDA-MB-231 cell proliferation, with an IC₅₀ value of 1.43 μM.

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分子式: C₁₉H₂₂Cl₃N₇O₄
分子量:518.78

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

CDC20-IN-1 構造式

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	6.47 μM Compound: E1	Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay	[PMID: 38364716]
L02	IC₅₀	14.66 μM Compound: E1	Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay	[PMID: 38364716]
MCF7	IC₅₀	3.27 μM Compound: E1	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay	[PMID: 38364716]
MDA-MB-231	IC₅₀	1.43 μM Compound: E1	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay	[PMID: 38364716]
MDA-MB-468	IC₅₀	7.24 μM Compound: E1	Antiproliferative activity against human MDA-MB-468 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay Antiproliferative activity against human MDA-MB-468 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay	[PMID: 38364716]

化学情報

分子量 518.78
分子式 C₁₉H₂₂Cl₃N₇O₄
SMILES

O=C(CC)NC(C(Cl)(Cl)Cl)N(C=N1)C2=C1C(NC3=CC(OC)=C(OC)C(OC)=C3)=NC(N)=N2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Zhao SF, et al. Design, synthesis and biological evaluation of CDC20 inhibitors for treatment of triple-negative breast cancer. Eur J Med Chem. 2024 Feb 8;268:116204. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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