PCGF3 - polycomb group ring finger 3 Gene

Also Known as RNF3; DONG1; RNF3A

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 10336

About PCGF3

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:705,832-770,089 (from NCBI)

This gene has 13 transcripts (splice variants), 212 orthologues and 7 paralogues. Ubiquitous expression in skin (RPKM 24.1), endometrium (RPKM 13.1) and 25 other tissues.

Summary

The protein encoded by this gene contains a C3HC4 type RING finger, which is a motif known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. [provided by RefSeq, Jul 2008]

PCGF3 Products (9)

mRNA Protein Name
NM_001317836.3 NP_001304765.1 polycomb group RING finger protein 3 isoform a
NM_001395245.1 NP_001382174.1 polycomb group RING finger protein 3 isoform a
NM_001395246.1 NP_001382175.1 polycomb group RING finger protein 3 isoform a
NM_001395247.1 NP_001382176.1 polycomb group RING finger protein 3 isoform a
NM_001395248.1 NP_001382177.1 polycomb group RING finger protein 3 isoform a
NM_001395249.1 NP_001382178.1 polycomb group RING finger protein 3 isoform a
NM_001395250.1 NP_001382179.1 polycomb group RING finger protein 3 isoform b
NM_001395251.1 NP_001382180.1 polycomb group RING finger protein 3 isoform b
NM_006315.7 NP_006306.2 polycomb group RING finger protein 3 isoform a

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
21282530 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
part of PcG protein complex IDA
IDA: Inferred from direct assay
21282530 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21282530 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PCGF3 Protein Structure

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (17 - 55)

  • 0
  • 100
  • 200
  • 242 a.a.
Protein Preferred Names Protein Names

polycomb group RING finger protein 3

  • RING finger protein 3A

PCGF3 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
PCGF3 Q3KNV8 CBX7 Homo sapiens O95931
Pull Down
21282530
Intra
PCGF3 Q3KNV8 CBX6 Homo sapiens O95503
Pull Down
21282530
Intra
PCGF3 Q3KNV8 CBX8 Homo sapiens Q9HC52
Pull Down
21282530
Intra
PCGF3 Q3KNV8 PHC2 Homo sapiens Q8IXK0
Y2H Prey Pooling
25416956
Intra
PCGF3 Q3KNV8 RNF2 Homo sapiens Q99496
TAP
27705803
Intra
PCGF3 Q3KNV8 RNF2 Homo sapiens Q99496
Y2H Array
22493164
Intra
PCGF3 Q3KNV8 RING1 Homo sapiens Q06587
TAP
27705803
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Shukla-Vernon Syndrome

  • SHUVER
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS10147 PCGF3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Rattus norvegicus PCGF3 RGD RGD:1311479
Bos taurus PCGF3 VGNC VGNC:97295
Canis familiaris PCGF3 VGNC VGNC:44302
Mus musculus PCGF3 MGD MGI:1916837
Felis catus PCGF3 VGNC VGNC:64067
Macaca mulatta PCGF3 VGNC VGNC:75593
Others PCGF3 NCBI