GPHA2 - glycoprotein hormone subunit alpha 2 Gene

Also Known as A2; GPA2; ZSIG51

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 170589

About GPHA2

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,934,471-64,937,708 (from NCBI)

This gene has 3 transcripts (splice variants) and 181 orthologues. Biased expression in pancreas (RPKM 14.6), testis (RPKM 3.2) and 2 other tissues.

Summary

GPHA2 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002 [PubMed 12089349]).[supplied by OMIM, Mar 2008]

GPHA2 Products (1)

mRNA Protein Name
NM_130769.4 NP_570125.1 glycoprotein hormone alpha-2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
12045258 GOA
enables protein heterodimerization activity IDA
IDA: Inferred from direct assay
12045258 GOA
enables thyrotropin-releasing hormone receptor binding IMP
IMP: Inferred from mutant phenotype
12045258 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12045258 GOA
involved in cell surface receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12045258 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in extracellular region IDA
IDA: Inferred from direct assay
12089349 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glycoprotein hormone alpha-2

  • cysteine knot protein

Recombinant GPHA2 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P76958 GPHA2 Protein, Human (HEK293, His) Q96T91 (Q24-Y129) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P76959 GPHA2 Protein, Human (HEK293, Fc) Q96T91 (Q24-Y129) ≥ 85%, as determined by reducing SDS-PAGE.

関連疾患

Diseases Alias
Salt And Pepper Syndrome

  • Salt & Pepper Syndrome

  • Salt-And-Pepper Syndrome
Voyeurism
Norrie Disease

  • Atrophia Bulborum Hereditaria

  • Episkopi Blindness

  • Pseudoglioma

  • ND

  • Norrie-Warburg Disease

  • Anderson-Warburg Syndrome

  • Fetal Iritis Syndrome

  • Norrie Syndrome

  • Norrie-Warburg Syndrome

  • Ndp

  • Congenital Progressive Oculo-Acoustico-Cerebral Degeneration

  • Norrie'S Disease

  • Oligophrenia Microphthalmus

  • Pseudoglioma Congenita

  • Whitnall-Norman Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS05637 GPHA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20030 Gpha2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26533 Gpha2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Bos taurus GPHA2 VGNC VGNC:29533
Macaca mulatta GPHA2 VGNC VGNC:72961
Felis catus GPHA2 VGNC VGNC:62664
Rattus norvegicus GPHA2 RGD RGD:621748
Mus musculus GPHA2 MGD MGI:2156541
Others GPHA2 NCBI