Hericenone D
Based on 1 Customer Validation
Hericenone D, an orally active pancreatic lipase inhibitor, can be found in Hericium erinaceus. Hericenone D reduces lipid absorption and stimulates nerve growth factor NGF gene expression. Hericenone D can be used for the research of menopausal obesity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.20%
- CAS 番号: 137592-04-2
- 分子式: C37H58O6
- 分子量:598.85
-
保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
Metabolism/Protease Compound Library
HY-L012
-
Natural Product Library
HY-L021
-
Endoplasmic Reticulum Stress Compound Library
HY-L054
-
Phenols Library
HY-L057
-
Orally Active Compound Library
HY-L061
-
Neuroprotective Compound Library
HY-L070
-
Microbial Metabolite Library
HY-L084
-
Anti-Obesity Compound Library
HY-L087
-
Lipid Metabolism Compound Library
HY-L091
-
Pain-Related Compound Library
HY-L139
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Natural Product Library Plus
HY-L021P
-
Natural Product and Natural Product-Like Compound Library
HY-L021M
-
Bioactive Compound Library
HY-L001
-
High-Throughput Bioactive Compound Library
HY-L205
-
High-Throughput Natural Product Library
HY-L206
-
Fungal-Sourced Compound Library
HY-L253
-
Mass Spectrometry Natural Product Library
HY-L262
生物活性
Hericenone D (3-100 μM; 24 h) does not exhibit significant neuroprotective activity against Tunicamycin (HY-A0098) or Thapsigargin (HY-13433)-induced ER stress-dependent cell death in murine neuroblastoma Neuro2a cells[1].
Hericenone D (400 μg/mL; 30 min) exhibits significant pancreatic lipase inhibitory activity in a cell-free biochemical assay at a concentration of 400 μg/mL[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:murine neuroblastoma Neuro2a cells
-
Concentration:3 μM; 10 μM; 30 μM
-
Incubation Time:24 h
-
Result:Did not exhibit significant neuroprotective activity against Tunicamycin or Thapsigargin-induced ER stress-dependent cell death.
Hericenone D (p.o.; 42 days) significantly reduces visceral and subcutaneous fat, decreases adipose tissue, increases lipid excreted from feces in female C57BL/6JJcl mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:C57BL/6JJcl mice (female; 12 weeks old)[1]
-
Dosage:~0.09 g/day
-
Administration:p.o.; 14 days
-
Result:Significantly reduced white adipose tissue in the visceral and subcutaneous fat.
Decreased fat tissue around the uterus and the kidney.
Significantly decreased the levels of total cholesterol and leptin in the plasma parameters.
化学情報
-
CAS 番号 137592-04-2
-
性状 Solid
-
分子量 598.85
-
分子式 C37H58O6
-
Color White to off-white
-
SMILES
CCCCCCCCCCCCCCCCCC(OCC1=C(C(O)=C(C(OC)=C1)C/C=C(C)/CC(/C=C(C)\C)=O)C=O)=O
-
Structure Classification
-
Initial Source
Hericium erinaceus
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
純度とドキュメンテーション
-
データシート (277 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. Kobayashi S, et al. Total Synthesis, Structure Revision, and Neuroprotective Effect of Hericenones C-H and Their Derivatives. J Org Chem. 2021;86(3):2602-2620. [Content Brief]
[2]. Hiraki E, et al. Anti-obesity activity of Yamabushitake (Hericium erinaceus) powder in ovariectomized mice, and its potentially active compounds. J Nat Med. 2017;71(3):482-491. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Hericenone D 関連分類
HY-N15385 関連分類
Powered by Bioz