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製品番号: HY-182438

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SDZ 51641

SDZ 51641 is an orally active fatty acid oxidation inhibitor. By reducing fatty acid oxidation, SDZ 51641 deprives the gluconeogenesis process of required energy and cofactors, thereby lowering blood glucose levels in diabetic models. SDZ 51641 can be used in diabetes research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 91456-99-4
分子式: C₁₄H₂₀O₂
分子量:220.31

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

SDZ 51641 構造式

CAS 番号: 91456-99-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体内実験

SDZ 51641 (70-100 μmol/kg; p.o.; days 1-11) reduces fatty acid oxidation and blood glucose levels without causing peripheral toxicity in 18-hour fasted normal Sprague‑Dawley rats and streptozotocin (STZ) (HY-13753)-induced diabetic rats^[1].
SDZ 51641 (700 µmol/kg; p.o.; once daily; for 28 days) reduces body weight and testicular weight, while increases liver weight, in normal Sprague Dawley rats compared with the control group^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Sprague‑Dawley rats treated STZ^[1]
Dosage:

70 µmol/kg
Administration:

p.o.; daily; 11 days
Result:

Inhibited hepatic fatty acid oxidation, decreased β‑hydroxybutyrate levels, reduced blood glucose production, and lowered serum glucose levels, while avoiding toxic effects on peripheral tissues such as the testes.

化学情報

CAS 番号 91456-99-4
分子量 220.31
分子式 C₁₄H₂₀O₂
SMILES

CC(C=C1)=CC=C1C2(C(C)(C)C)OCCO2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Bebernitz GR, et al. Reduction in glucose levels in STZ diabetic rats by 4-(2,2-dimethyl-1-oxopropyl)benzoic acid: a prodrug approach for targeting the liver. J Med Chem. 2001;44(4):512-523. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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