Cavα2δ1&NET-IN-2
Cavα2δ1&NET-IN-2 (Compound 45CS) is a dual inhibitor of the α2δ‑1 subunit of voltage-gated calcium channels (Cavα2δ-1) and the norepinephrine transporter (NET). Cavα2δ1&NET-IN-2 inhibits Cavα2δ-1 with a Ki of 454 nM. Cavα2δ1&NET-IN-2 inhibits NET with a Ki of 59 nM and IC50 of 7 nM. Cavα2δ1&NET-IN-2 can be used for research of pain.
For research use only. We do not sell to patients.
- CAS No.: 2143586-17-6
- Formula: C22H26N6O2S
- Molecular Weight:438.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Calcium Channel Isoforms
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Biological Activity
Cavα2δ1: 112 nM (Ki);
NET: 383 nM (Ki), 67 nM (IC50).
Chemical Information
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CAS No. 2143586-17-6
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Molecular Weight 438.55
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Formula C22H26N6O2S
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SMILES
O=C1N(CCN(C2=NC(N)=NC=C21)C)C3=CC(O[C@H](C4=CC=CS4)CCNC)=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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