2143586-17-6
Chemical Structure
Cavα2δ1&NET-IN-2
- CAS 番号: 2143586-17-6
- Formula:C22H26N6O2S
- Molecular Weight:438.55
IUPAC Name: (S)-2-amino-9-methyl-6-(3-(3-(methylamino)-1-(thiophen-2-yl)propoxy)phenyl)-6,7,8,9-tetrahydro-5H-pyrimido[4,5-e][1,4]diazepin-5-one
InChIKey: IWLOXSUFFLVQCV-SFHVURJKSA-N
SMILES: O=C1N(CCN(C2=NC(N)=NC=C21)C)C3=CC(O[C@H](C4=CC=CS4)CCNC)=CC=C3
Biological Activity: Cavα2δ1&NET-IN-2 (Compound 45CS) is a dual inhibitor of the α2δ‑1 subunit of voltage-gated calcium channels (Cavα2δ-1) and the norepinephrine transporter (NET). Cavα2δ1&NET-IN-2 inhibits Cavα2δ-1 with a Ki of 454 nM. Cavα2δ1&NET-IN-2 inhibits NET with a Ki of 59 nM and IC50 of 7 nM. Cavα2δ1&NET-IN-2 can be used for research of pain[1].
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Cavα2δ1&NET-IN-2 | Cavα2δ1&NET-IN-2 (Compound 45CS) is a dual inhibitor of the α2δ‑1 subunit of voltage-gated calcium channels (Cavα2δ-1) and the norepinephrine transporter (NET). Cavα2δ1&NET-IN-2 inhibits Cavα2δ-1 with a Ki of 454 nM. Cavα2δ1&NET-IN-2 inhibits NET with a Ki of 59 nM and IC50 of 7 nM. Cavα2δ1&NET-IN-2 can be used for research of pain. | |||||||||||||||||||||
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Keywords
