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MIIP - migration and invasion inhibitory protein Gene

Also Known as IIP45

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 60672

About MIIP

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:12,019,498-12,032,045 (from NCBI)

This gene has 7 transcripts (splice variants) and 169 orthologues. Ubiquitous expression in bone marrow (RPKM 14.3), testis (RPKM 8.7) and 24 other tissues.

Summary

This gene encodes a protein that interacts with the oncogene protein insulin-like growth factor binding protein 2 and may function as an inhibitor of cell migration and invasion. This protein also interacts with the cell division protein 20 and may be involved in regulating mitotic progression. This protein may function as a tumor suppressor by inhibiting the growth or certain cancers. [provided by RefSeq, Sep 2011]

MIIP Products (1)

mRNA	Protein	Name
NM_021933.4	NP_068752.2	migration and invasion-inhibitory protein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
migration and invasion-inhibitory protein	IGFBP2-binding protein

MIIP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MIIP	Q5JXC2	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	MIIP	Q5JXC2	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	MIIP	Q5JXC2	KPRP	Homo sapiens	Q5T749	Y2H Prey Pooling	32296183
Intra	MIIP	Q5JXC2	KPRP	Homo sapiens	Q5T749	Validated Y2H	32296183
Intra	MIIP	Q5JXC2	KPRP	Homo sapiens	Q5T749	Y2H Array	32296183
Intra	MIIP	Q5JXC2	MOB2	Homo sapiens	Q70IA6	Validated Y2H	32296183
Intra	MIIP	Q5JXC2	CHAT	Homo sapiens	P28329-3	Y2H Array	32814053
Intra	MIIP	Q5JXC2	CHAT	Homo sapiens	P28329-3	Validated Y2H	32814053
Intra	MIIP	Q5JXC2	CHAT	Homo sapiens	P28329-3	Y2H Pooling	32814053
Intra	MIIP	Q5JXC2	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
Intra	MIIP	Q5JXC2	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
Intra	MIIP	Q5JXC2	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
Intra	MIIP	Q5JXC2	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	MIIP	Q5JXC2	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	MIIP	Q5JXC2	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	MIIP	Q5JXC2	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	MIIP	Q5JXC2	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	MIIP	Q5JXC2	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	MIIP	Q5JXC2	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	MIIP	Q5JXC2	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	MIIP	Q5JXC2	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	MIIP	Q5JXC2	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	MIIP	Q5JXC2	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	MIIP	Q5JXC2	KCTD9	Homo sapiens	Q7L273	Validated Y2H	32296183
Intra	MIIP	Q5JXC2	MED28	Homo sapiens	Q9H204	Validated Y2H	32296183
Intra	MIIP	Q5JXC2	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	MIIP	Q5JXC2	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	MIIP	Q5JXC2	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	MIIP	Q5JXC2	OIP5	Homo sapiens	O43482	Y2H Prey Pooling	32296183
Intra	MIIP	Q5JXC2	OIP5	Homo sapiens	O43482	Y2H Array	32296183
Intra	MIIP	Q5JXC2	MLLT3	Homo sapiens	P42568	Anti Tag CoIP	33961781
Intra	MIIP	Q5JXC2	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	32296183
Intra	MIIP	Q5JXC2	ZNF417	Homo sapiens	Q8TAU3	Validated Y2H	32296183
Intra	MIIP	Q5JXC2	TCHP	Homo sapiens	Q9BT92	Validated Y2H	32296183
Intra	MIIP	Q5JXC2	TRIP6	Homo sapiens	Q15654	Y2H Array	32296183
Intra	MIIP	Q5JXC2	TRIP6	Homo sapiens	Q15654	Y2H Prey Pooling	32296183
Intra	MIIP	Q5JXC2	CCDC120	Homo sapiens	Q96HB5	Validated Y2H	32296183
Intra	MIIP	Q5JXC2	STK16	Homo sapiens	O75716	Y2H Prey Pooling	25416956
Intra	MIIP	Q5JXC2	TEKT4	Homo sapiens	Q8WW24	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Prolapse Of Urethra	Urethrocele
Glioma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08448	MIIP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21377	Miip Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27896	Miip Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MIIP	MGD	MGI:106506
Felis catus	MIIP	VGNC	VGNC:63506
Macaca mulatta	MIIP	VGNC	VGNC:74829
Rattus norvegicus	MIIP	RGD	RGD:1587376
Bos taurus	MIIP	VGNC	VGNC:31475
Canis familiaris	MIIP	VGNC	VGNC:43234
Others	MIIP	NCBI