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Cat. No.: HY-185347

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AChE-IN-114

AChE-IN-114 is a selective AChE inhibitor and shows weak inhibitory activity for BChE. AChE-IN-114 can be used for the research of alzheimer’s disease.

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CAS No.: 2365405-51-0
화학식: C₁₈H₁₂Cl₂O₃
분자량:347.19

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

AChE-IN-114 Chemical Structure

CAS No.: 2365405-51-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

AChE-IN-114 is a selective AChE inhibitor and shows weak inhibitory activity for BChE. AChE-IN-114 can be used for the research of alzheimer’s disease^[1].

IC₅₀ & Target^[1]

AChE

BChE

All Cholinesterase (ChE) Isoforms :

AChE
BChE

In Vitro

AChE-IN-114 (Compound 2v) (10 μM) acts as a mixed type inhibitor of electric eel acetylcholinesterase with a K_i of 12.19-21.46 μM, shows minimal butyrylcholinesterase inhibition, and is non-cytotoxic to multiple human tumor and non-malignant mouse fibroblast cell lines with an EC₅₀ >30 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2365405-51-0
분자량 347.19
화학식 C₁₈H₁₂Cl₂O₃
SMILES

O=C(OC(/C=C/C1=CC=CC=C1Cl)=O)/C=C/C2=CC=CC(Cl)=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Gießel JM, et al. Substituted cinnamic anhydrides act as selective inhibitors of acetylcholinesterase. Bioorg Chem. 2019;90:103058. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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