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SENP5 - SUMO specific peptidase 5 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 205564

About SENP5

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:196,867,920-196,934,714 (from NCBI)

This gene has 7 transcripts (splice variants), 158 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 8.4), brain (RPKM 6.3) and 25 other tissues.

Summary

The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]

SENP5 Products (2)

mRNA	Protein	Name
NM_001308045.2	NP_001294974.1	sentrin-specific protease 5 isoform 2
NM_152699.5	NP_689912.2	sentrin-specific protease 5 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables SUMO-specific endopeptidase activity	EXP EXP: Inferred from Experiment	16608850	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21217774	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SENP5 Protein Structure

Peptidase_C48

0
200
400
600
755 a.a.

Protein Preferred Names	Protein Names
sentrin-specific protease 5	SUMO1/sentrin specific peptidase 5

SENP5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SENP5	Q96HI0	ESR1	Homo sapiens	P03372	Phage Display	21217774
Intra	SENP5	Q96HI0	ESR1	Homo sapiens	P03372	Y2H	21217774

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
3-Methylglutaconic Aciduria, Type Iii	Optic Atrophy 3-Methylglutaconic Aciduria Type 3 Costeff Syndrome Mga3 Costeff Optic Atrophy Syndrome Optic Atrophy Plus Syndrome Infantile Optic Atrophy With Chorea And Spastic Paraplegia 3-Methylglutaconic Aciduria Type Iii Autosomal Recessive Optic Atrophy Plus Syndrome Autosomal Recessive Optic Atrophy Type 3 Opa3 Defect MGCA3 Mga, Type Iii Iraqi Jewish Optic Atrophy Plus Mga Type Iii Optic Atrophy, Infantile, With Chorea And Spastic Paraplegia Iraqi-Jewish 'Optic Atrophy Plus' Optic Atrophy 3, Autosomal Recessive Opa3, Autosomal Recessive Opa3-Related 3-Methylglutaconic Aciduria Iraqi-Jewish Optic Atrophy Plus Atrophy Of Optic Disc 3-Alpha Methylglutaconic Aciduria Type Iii Optic Atrophy 3 Optic Atrophy Infantile With Chorea And Spastic Paraplegia Autosomal Recessive Opa3 Autosomal Recessive Optic Atrophy 3 3-Methylglutaconic Aciduria 3 3-Alpha-Methylglutaconic Aciduria Type 3 Optic Atrophy 3 Autosomal Recessive Atrophy, Optic Atrophy, Optic, Plus Syndrome Optic Nerve Atrophy Primary Optic Atrophy Oa - [Optic Atrophy] Second Cranial Nerve Atrophy Second Cranium Nerve Atrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-151358	SENP2-IN-1	Inhibitor	98.05%	Unkown
HY-RS12674	SENP5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SENP5	VGNC	VGNC:34447
Macaca mulatta	SENP5	VGNC	VGNC:77321
Canis familiaris	SENP5	VGNC	VGNC:46007
Felis catus	SENP5	VGNC	VGNC:65003
Mus musculus	SENP5	MGD	MGI:2443596
Rattus norvegicus	SENP5	RGD	RGD:1304604
Others	SENP5	NCBI