ACVRL1 - activin A receptor like type 1 Gene

Also Known as HHT; ALK1; HHT2; ORW2; SKR3; ALK-1; TSR-I; ACVRLK1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 94

About ACVRL1

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:51,906,944-51,923,361 (from NCBI)

This gene has 8 transcripts (splice variants), 358 orthologues, 11 paralogues and is associated with 4 phenotypes. Broad expression in placenta (RPKM 37.6), lung (RPKM 28.7) and 18 other tissues.

Summary

This gene encodes a type I cell-surface receptor for the TGF-beta Superfamily of ligands. It shares with Other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with Other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008]

ACVRL1 Products (15)

mRNA	Protein	Name
NM_001406493.1	NP_001393422.1	serine/threonine-protein kinase receptor R3 isoform 5 precursor
NM_001406492.1	NP_001393421.1	serine/threonine-protein kinase receptor R3 isoform 4 precursor
NM_001406490.1	NP_001393419.1	serine/threonine-protein kinase receptor R3 isoform 3 precursor
XM_047429903.1	XP_047285859.1	serine/threonine-protein kinase receptor R3 isoform X3
NM_001406489.1	NP_001393418.1	serine/threonine-protein kinase receptor R3 isoform 2 precursor
NM_001406487.1	NP_001393416.1	serine/threonine-protein kinase receptor R3 isoform 1 precursor
NM_000020.3	NP_000011.2	serine/threonine-protein kinase receptor R3 isoform 1 precursor
XM_047429901.1	XP_047285857.1	serine/threonine-protein kinase receptor R3 isoform X1
NM_001406494.1	NP_001393423.1	serine/threonine-protein kinase receptor R3 isoform 6 precursor
NM_001406488.1	NP_001393417.1	serine/threonine-protein kinase receptor R3 isoform 2 precursor
NM_001406495.1	NP_001393424.1	serine/threonine-protein kinase receptor R3 isoform 7 precursor
NM_001406491.1	NP_001393420.1	serine/threonine-protein kinase receptor R3 isoform 4 precursor
XM_011539008.2	XP_011537310.1	serine/threonine-protein kinase receptor R3 isoform X2
NM_001077401.2	NP_001070869.1	serine/threonine-protein kinase receptor R3 isoform 1 precursor
XM_005269235.3	XP_005269292.1	serine/threonine-protein kinase receptor R3 isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	12065756	GOA
enables BMP receptor activity	IDA IDA: Inferred from direct assay	12065756	GOA
enables BMP receptor activity	IGI IGI: Inferred from genetic interaction	32082362	GOA
enables BMP receptor activity	IMP IMP: Inferred from mutant phenotype	26176610	GOA
enables SMAD binding	IDA IDA: Inferred from direct assay	12065756	GOA
enables activin binding	IDA IDA: Inferred from direct assay	8242742	GOA
enables activin receptor activity, type I	IDA IDA: Inferred from direct assay	8242742	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8242742	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	19592636	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	12065756	GOA
enables transforming growth factor beta binding	IPI IPI: Inferred from physical interaction	8242742	GOA
enables transforming growth factor beta receptor activity	IDA IDA: Inferred from direct assay	8242742	GOA
enables transforming growth factor beta receptor activity, type I	IDA IDA: Inferred from direct assay	8242742	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in BMP signaling pathway	IDA IDA: Inferred from direct assay	12065756	GOA
involved in BMP signaling pathway	IGI IGI: Inferred from genetic interaction	32561494	GOA
involved in BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	19366699	GOA
involved in angiogenesis	IMP IMP: Inferred from mutant phenotype	16752392	GOA
involved in blood circulation	IMP IMP: Inferred from mutant phenotype	16752392	GOA
involved in cellular response to BMP stimulus	IMP IMP: Inferred from mutant phenotype	19366699	GOA
involved in cellular response to transforming growth factor beta stimulus	IDA IDA: Inferred from direct assay	19494318	GOA
involved in endothelial tube morphogenesis	IMP IMP: Inferred from mutant phenotype	19592636	GOA
involved in lymphatic endothelial cell differentiation	IMP IMP: Inferred from mutant phenotype	19903896	GOA
involved in negative regulation of blood vessel endothelial cell migration	IMP IMP: Inferred from mutant phenotype	19592636	GOA
involved in negative regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	12453878	GOA
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	17068149	GOA
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	12453878	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12453878	GOA
involved in negative regulation of endothelial cell migration	IDA IDA: Inferred from direct assay	17068149	GOA
involved in negative regulation of focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	12453878	GOA
involved in positive regulation of BMP signaling pathway	IDA IDA: Inferred from direct assay	17068149	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12393874	GOA
acts upstream of positive regulation of Notch signaling pathway	IGI IGI: Inferred from genetic interaction	32561494	GOA
involved in positive regulation of SMAD protein signal transduction	IMP IMP: Inferred from mutant phenotype	19366699	GOA
involved in positive regulation of bicellular tight junction assembly	IGI IGI: Inferred from genetic interaction	32561494	GOA
acts upstream of positive regulation of epithelial cell differentiation	IGI IGI: Inferred from genetic interaction	32561494	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19366699	GOA
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	15702480	GOA
involved in regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	14684682	GOA
involved in signal transduction	IDA IDA: Inferred from direct assay	15702480	GOA
involved in transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	15702480	GOA
involved in wound healing, spreading of epidermal cells	IMP IMP: Inferred from mutant phenotype	12453878	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	8242742	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	8242742	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACVRL1 Protein Structure

Activin_recp

TGF_beta_GS

Pkinase

0
100
200
300
400
503 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase receptor R3	TGF-B superfamily receptor type I activin A receptor type II-like 1 activin A receptor type IL activin A receptor, type II-like kinase 1

ACVRL1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ACVRL1	P37023	PDXDC2P	Homo sapiens	Q6P474	Anti Tag CoIP	33961781
Intra	ACVRL1	P37023	PDXDC2P	Homo sapiens	Q6P474	Anti Tag CoIP	28514442
Intra	ACVRL1	P37023	Q9UK05-PRO_0000033903	Homo sapiens	Q9UK05-PRO_0000033903	Pull Down	28564608
Intra	ACVRL1	P37023	LRG1	Homo sapiens	P02750	Anti Bait CoIP	23868260

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ACVRL1 Proteins

Cat. No.	상품명	Accession	Purity
HY-P7480	ALK-1 Protein, Human (HEK293, Fc)	P37023 (D22-Q118)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72818	ALK-1 Protein, Human (HEK293, His)	P37023 (D22-Q118)	≥ 90%, as determined by reducing SDS-PAGE.

ACVRL1 Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P810842	ALK1 Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P82712	ALK-1 Antibody (YA2457)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Cerebral Cavernous Malformations	Cerebral Cavernous Malformation Cavernous Malformations Of Cns And Retina Cerebral Cavernous Malformation 1 Cavernous Angiomatous Malformations Cerebral Capillary Malformations CCM Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations Familial Cavernous Angioma Familial Cerebral Cavernous Malformation Cerebral Cavernous Malformations 1 Cavernous Angioma, Familial Cam Cerebral Cavernous Malformations-1 Cavernoma Cavernous Angioma Central Nervous System Cavernous Hemangioma Cerebral Cavernous Hemangioma Familial Cavernous Hemangioma Familial Cavernous Malformation Familial Cerebral Cavernous Angioma Intracerebral Cavernous Hemangioma CCM1 Cavernous Hemangioma Of The Brain Cerebral Cavernoma Cerebral Cavernous Malformations, Type 1 Hemangioma, Cavernous, Central Nervous System Hemangioma, Cavernous Angioma, Cavernous
Juvenile Polyposis Syndrome	JPS Juvenile Intestinal Polyposis Jip Pji Juvenile Gastrointestinal Polyposis Juvenile Polyposis Polyposis, Juvenile Intestinal Polyposis, Familial, Of Entire Gastrointestinal Tract Polyposis Familial Of Entire Gastrointestinal Tract Polyposis Juvenile Intestinal Polyposis Syndrome, Juvenile
Contractures, Pterygia, And Spondylocarpotarsal Fusion Syndrome 1a	Multiple Pterygium Syndrome, Autosomal Dominant CPSFS1A Contractures, Pterygia, And Spondylocarpostarsal Fusion Syndrome 1a Autosomal Dominant Disease Contractures, Pterygia, And Variable Skeletal Fusions Syndrome 1a Cpskf1a Pterygium Syndrome, Multiple Autosomal Dominant Arthrogryposis, Distal, Type 8, Formerly Da8, Formerly Autosomal Dominant Multiple Pterygium Syndrome Distal Arthrogryposis Type 8 Arthrogryposis, Distal, Type 8 Da8 Pterygium Syndrome, Multiple, Autosomal Dominant Autosomal Dominant Disorder
Loeys-Dietz Syndrome	Loeys-Dietz Aortic Aneurysm Syndrome Lds Aortic Aneurysm Syndrome Due To Tgf-Beta Receptors Anomalies Furlong Syndrome
Klippel-Trenaunay-Weber Syndrome	Klippel-Trenaunay Syndrome KTS Ktw Syndrome Angioosteohypertrophy Syndrome Angio-Osteohypertrophy Syndrome Klippel Trenaunay Syndrome Klippel-Trénaunay-Weber Syndrome Haemangiectatic Hypertrophy Weber-Klippel-Trenaunay Congenital Dysplastic Angiopathy Klippel-Trenaunay Disease Weber Klippel Trenaunay
Cardiovascular Organ Benign Neoplasm
Pulmonary Hypertension, Primary, 1	Pulmonary Arterial Hypertension Pah Idiopathic Pulmonary Arterial Hypertension Idiopathic Pulmonary Hypertension Primary Pulmonary Hypertension PPH1 Pulmonary Hypertension, Familial Primary, 1, With Or Without Hht Pulmonary Hypertension, Primary, Fenfluramine Or Dexfenfluramine-Associated Pph Familial Primary Pulmonary Hypertension Sporadic Primary Pulmonary Hypertension Pht Fpah Familial Pulmonary Arterial Hypertension Hereditary Pulmonary Arterial Hypertension Heritable Pulmonary Arterial Hypertension Ayerza Syndrome Fpph Ppht Ipah Primary Pulmonary Arterial Hypertension Pulmonary Hypertension, Familial Primary Hypertension, Pulmonary, Primary, Type 1 Ayerza'S Syndrome Pah - [Pulmonary Arterial Hypertension] Arrillaga Ayerza Syndrome
Fumarate Hydratase Deficiency	Fumarase Deficiency Fumaric Aciduria
Castleman Disease	Angiofollicular Ganglionic Hyperplasia Angiofollicular Lymph Hyperplasia Giant Lymph Node Hyperplasia Castleman'S Disease Angiofollicular Lymph Node Hyperplasia Lymphoid Hamartoma Benign Giant Lymphoma Angiolymphoid Hyperplasia
Telangiectasis	Telangiectasia
Peripheral Vascular Disease	Peripheral Arterial Disease Arterial Occlusive Disease Arterial Occlusive Diseases Pad Peripheral Vascular Diseases Peripheral Occlusive Disease Peripheral Arterial Diseases Helicobacter Infections
Hepatopulmonary Syndrome
Embryonal Rhabdomyosarcoma	Rhabdomyosarcoma, Embryonal Rhabdomyosarcoma Embryonal Botryoid Rhabdomyosarcoma Erms Spindle Cell Rhabdomyosarcomas
Angiodysplasia	Angiodysplasia Of Colon Angiodysplasia Of Stomach And Duodenum With Hemorrhage Angiodysplasia Of Large Intestine Telangiectasia Of Colon Vascular Ectasia Of Colon Av - [Angiodysplasia Malformation Of Colon] Colon Angiodysplasia Colonic Angiodysplasia Vascular Ectasia Of Large Intestine
Connective Tissue Disease	Connective Tissue Diseases Connective Tissue Disorder Abnormality Of Connective Tissue Disorder Of Connective Tissue Connective Tissue Disorders
Vascular Disease	Vascular Diseases Aneurysm Spinal Cord Ischemia Spinal Cord Vascular Diseases Vascular Tissue Disease Vascular Anomaly
Pulmonary Hypertension	Primary Pulmonary Hypertension Hypertension Pulmonary Hypertension, Pulmonary Idiopathic Pulmonary Hypertension Idiopathic Pulmonary Arterial Hypertension Pulmonary Htn - [Hypertension]
Telangiectasia, Hereditary Hemorrhagic, Type 1	Orw Disease HHT1 Hht Telangiectasia, Hereditary Hemorrhagic, Of Rendu, Osler, And Weber Osler-Rendu-Weber Disease Telangiectasia, Hereditary Hemorrhagic, 1 Hereditary Hemorrhagic Telangiectasia Of Rendu, Osler, And Weber Orw1 Osler-Rendu-Weber Syndrome Osler-Rendu-Weber Syndrome 1 Telangiectasia Hemorrhagic, Hereditary, Type 1 Hereditary Hemorrhagic Telangiectasia
Juvenile Polyposis/Hereditary Hemorrhagic Telangiectasia Syndrome	Juvenile Polyposis-Hereditary Hemorrhagic Telangiectasia Syndrome JPHT Jp/Hht Syndrome Juvenile Polyposis With Hereditary Hemorrhagic Telangiectasia Jps/Hht Telangiectasia, Hereditary Hemorrhagic, With Juvenile Polyposis Coli Polyposis, Generalized Juvenile, With Pulmonary Arteriovenous Malformation Jp-Hht JP/HHT Polyposis, Juvenile/Hereditary Hemorrhagic Telangiectasia Syndrome
Lymphoproliferative Syndrome, X-Linked, 1	Lymphomatoid Papulosis Duncan Disease Purtilo Syndrome X-Linked Lymphoproliferative Syndrome Xlp XLP1 Lyp X-Linked Lymphoproliferative Disease Lymphoproliferative Disease, X-Linked Xlpd X-Linked Lymphoproliferative Disease Due To Sh2d1a Deficiency Ebv Infection, Severe, Susceptibility To Ebvs Immunodeficiency 5 Imd5 X-Linked Lymphoproliferative Syndrome 1 Epstein-Barr Virus Infection, Familial Fatal Ebv Infection, Severe Infectious Mononucleosis, Severe Infectious Mononucleosis, Severe, Susceptibility To Immunodeficiency, X-Linked Progressive Combined Variable Epstein Barr Virus Infection, Familial Fatal X-Linked Progressive Combined Variable Immunodeficiency 5 Epstein-Barr Virus-Induced Lymphoproliferative Disease In Males Familial Fatal Epstein-Barr Infection Severe Susceptibility To Ebv Infection Severe Susceptibility To Infectious Mononucleosis Sap Deficiency Sh2d1a/Slam-Associated Protein Deficiency X-Linked Lymphoproliferative Syndrome Type 1 X-Linked Progressive Combined Variable Immunodeficiency Lymphoproliferative Syndrome, X-Linked Sap X-Linked Lymphoproliferative Disorder
Brachydactyly, Type A2	Brachydactyly Type A2 BDA2 Mohr-Wriedt Type Brachydactyly Brachymesophalangy Ii Brachymesophalangy Type 2 Brachymesophalangy 2 Brachydactyly, Mohr-Wriedt Type Brachydactyly A2
Active Peptic Ulcer Disease	Gi Bleeding Active Peptic Ulcer Gastrointestinal Hemorrhage
Aortic Aneurysm, Familial Thoracic 1	Thoracic Aortic Aneurysm Annuloaortic Ectasia Familial Thoracic Aortic Aneurysm And Aortic Dissection Familial Aortic Dissection Familial Taad Congenital Aneurysm Of Ascending Aorta Familial Aortic Aneurysm Familial Thoracic Aortic Aneurysm Familial Thoracic Aortic Aneurysm And Dissection Aortic Aneurysm, Thoracic AAT1 Faa1 Aortic Dissection, Familial Aortic Aneurysm, Familial Thoracic Aneurysm, Thoracic Aortic Faa Ftaad Taa Taad Cystic Medial Necrosis Of Aorta Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection Aortic Aneurysm Thoracic Familial Aortic Aneurysms Aneurysm, Aortic, Thoracic, Familial, Type 1 Aneurysm Of Thoracic Aorta Intrathoracic Aneurysm Thoracic Aorta Aneurysm Thoracic Aortic Aneurysm Without Rupture Thoracic Aneurysm Thorax Arterial Aneurysm Thoracic Artery Aneurysm Thoracic Arterial Aneurysm Thorax Aneurysm Thorax Aortic Aneurysm Dissection Of Thoracic Aorta
Hepatic Vascular Disease	Vascular Disorder Of Liver
Arteriovenous Malformation	Arteriovenous Malformations Arteriovenous Hemangioma Cirsoid Aneurysm Racemose Aneurysm Racemose Angioma Racemose Hemangioma Congenital Arteriovenous Malformation
Infiltrating Angiolipoma	Angiolipoma, Infiltrating
Pulmonary Venoocclusive Disease	Pulmonary Veno-Occlusive Disease Obstructive Disease Of The Pulmonary Veins Pvod Isolated Pulmonary Venous Sclerosis Venous Form Of Primary Pulmonary Hypertension Pulmonary Venoocclusive Disease 1, Autosomal Dominant
Weber Syndrome	Midbrain Stroke Syndromes
Heritable Pulmonary Arterial Hypertension	Fpah Familial Pulmonary Arterial Hypertension Hpah Hereditary Pulmonary Arterial Hypertension Familial Primary Pulmonary Hypertension
Telangiectasia, Hereditary Hemorrhagic, Type 2	HHT2 Hereditary Hemorrhagic Telangiectasia Type 2 Orw2 Osler Weber Rendu Syndrome Type 2 Telangiectasia Hereditary Hemorrhagic Type 2 Telangiectasia, Hereditary Hemorrhagic, 2 Telangiectasia, Hemorrhagic, Hereditary, Type 2 Osler-Rendu-Weber Syndrome 2
Chronic Pulmonary Heart Disease
Patent Foramen Ovale	Atrial Septal Defect Within Oval Fossa Foramen Ovale Patent Ostium Secundum Atrial Septal Defect Atrial Septal Defect, Ostium Secundum Type Foramen Ovale, Patent Defect, Patent Or Persistent, Ostium Secundum Ostium Secundum Type Atrial Septal Defect Persistent Ostium Secundum Asd Ostium Secundum Type Ostium Secundum Asd Osasd Asd, Ostium Secundum Type Pfo - [Patent Foramen Ovale] Open Foramen Ovale Open Oval Foramen Persistent Foramen Ovale Secundum Atrial Septal Defect
Fumarase Deficiency	Fumaric Aciduria FMRD Fumarate Hydratase Deficiency Deficiency, Fumarase
Sturge-Weber Syndrome	SWS Encephalotrigeminal Angiomatosis Encephalofacial Angiomatosis Sturge-Weber-Dimitri Syndrome Sturge-Weber-Krabbe Syndrome Fourth Phacomatosis Leptomeningeal Angiomatosis Meningeal Capillary Angiomatosis Sturge-Weber-Krabbe Angiomatosis Sturge-Weber Syndrome, Somatic, Mosaic Sws Type I - Facial And Leptomeningeal Angiomas Sws Type Ii - Facial Angioma Alone, No Cns Involvement Sws Type Iii - Isolated Leptomeningeal Angiomas Sturge Weber Syndrome Angiomatosis Aculoorbital-Thalamic Syndrome Encephalofacial Hemangiomatosis Encephalofacial Hemangiomatosis Syndrome Meningo-Oculo-Facial Angiomatosis Meningofacial Angiomatosis-Cerebral Calcification Syndrome Neuroretinoangiomatosis Phakomatosis, Sturge-Weber Weber-Sturge-Dimitri Syndrome
Anaplastic Large Cell Lymphoma	Alcl Cd30 Positive Anaplastic Large Cell Lymphoma Ki-1 Positive Anaplastic Large Cell Lymphoma Primary Systemic Alcl Sacl Ki-1+ Anaplastic Large Cell Lymphoma
Ischiocoxopodopatellar Syndrome With Or Without Pulmonary Arterial Hypertension	Small Patella Syndrome Ischiopatellar Dysplasia Coxopodopatellar Syndrome Scott-Taor Syndrome Sps Ischiocoxopodopatellar Syndrome Patella Aplasia, Coxa Vara, And Tarsal Synostosis ICPPS Congenital Coxa Vara, Patella Aplasia And Tarsal Synostosis Coxo-Podo-Patellar Syndrome Patella Aplasia, Coxa Vara, Tarsal Synostosis Coxopodipatellar Syndrome
Hereditary Hemorrhagic Telangiectasia	Rendu-Osler-Weber Disease Hht Osler-Weber-Rendu Disease Telangiectasia, Hereditary Hemorrhagic Osler Hemorrhagic Telangiectasia Syndrome Orw Disease Osler Weber Rendu Syndrome Osler-Rendu-Weber Disease Osler-Weber-Rendu Syndrome Rendu-Osler Disease Telangiectasia Hereditary Hemorrhagic Telangiectasia Hemorrhagic, Hereditary Hht - [Hereditary Haemorrhagic Telangiectasia] Osler Haemorrhagic Telangiectasia Syndrome
Venous Malformations, Multiple Cutaneous And Mucosal	VMCM Multiple Cutaneous And Mucosal Venous Malformations Mucocutaneous Venous Malformations Vmcm1 Cutaneous And Mucosal Venous Malformation Dominantly Inherited Venous Malformations
Hemangioma Of Lung	Pulmonary Hemangioma
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Mixed Connective Tissue Disease	Sharp Syndrome Mctd Connective Tissue Disease Overlap Syndrome Mixed Collagen Vascular Disease Mctd - [Mixed Connective Tissue Disease]
Splenic Artery Aneurysm	Aneurysm Of Splenic Artery
Arteriovenous Malformations Of The Brain	Cerebral Arteriovenous Malformation Intracranial Arteriovenous Malformation Intracranial Hemorrhage In Brain Cerebrovascular Malformations, Susceptibility To Intracranial Arteriovenous Malformations Bavm Cerebral Arteriovenous Malformations Intracranial Hemorrhage In Brain Cerebrovascular Malformations Arteriovenous Malformation Of The Brain, Somatic Intracranial Avm Arteriovenous Malformations Cerebral

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	상품명	효과	Purity	Phase
HY-P99353	Ascrinvacumab	Inhibitor	97.45%	Phase 2

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS00251	ACVRL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00252	Acvrl1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00253	Acvrl1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174781	Human ACVRL1 mRNA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ACVRL1	VGNC	VGNC:69451
Canis familiaris	ACVRL1	VGNC	VGNC:37566
Felis catus	ACVRL1	VGNC	VGNC:59567
Mus musculus	ACVRL1	MGD	MGI:1338946
Rattus norvegicus	ACVRL1	RGD	RGD:2029
Bos taurus	ACVRL1	VGNC	VGNC:25597
Others	ACVRL1	NCBI