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LRG1 - leucine rich alpha-2-glycoprotein 1 Gene

Also Known as LRG; HMFT1766

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 116844

About LRG1

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,536,402-4,540,036 (from NCBI)

This gene has 2 transcripts (splice variants), 289 orthologues and 22 paralogues. Biased expression in liver (RPKM 150.7), esophagus (RPKM 16.6) and 4 other tissues.

Summary

The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation (O'Donnell et al., 2002 [PubMed 12223515]).[supplied by OMIM, Mar 2008]

LRG1 Products (1)

mRNA	Protein	Name
NM_052972.3	NP_443204.1	leucine-rich alpha-2-glycoprotein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23868260	GOA
enables type I transforming growth factor beta receptor binding	IPI IPI: Inferred from physical interaction	23868260	GOA
enables type II transforming growth factor beta receptor binding	IPI IPI: Inferred from physical interaction	23868260	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of keratinocyte migration	IMP IMP: Inferred from mutant phenotype	32887674	GOA
acts upstream of leukocyte adhesion to vascular endothelial cell	IMP IMP: Inferred from mutant phenotype	32887674	GOA
acts upstream of positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	32887674	GOA
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	23868260	GOA
acts upstream of positive regulation of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	23868260	GOA
acts upstream of positive regulation of epithelial cell proliferation involved in wound healing	IMP IMP: Inferred from mutant phenotype	32887674	GOA
involved in positive regulation of epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	32887674	GOA
acts upstream of positive regulation of keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	32887674	GOA
involved in positive regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	23868260	GOA
acts upstream of or within wound healing, spreading of epidermal cells	IMP IMP: Inferred from mutant phenotype	32887674	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	20363744	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRG1 Protein Structure

LRR_1

LRR_8

LRR_1

LRR_8

0
100
200
300
347 a.a.

Protein Preferred Names	Protein Names
leucine-rich alpha-2-glycoprotein	1300008B03Rik

LRG1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LRG1	P02750	ENG	Homo sapiens	P17813-1	Anti Bait CoIP	23868260
Intra	LRG1	P02750	ENG	Homo sapiens	P17813-1	SPR	23868260
Intra	LRG1	P02750	TGFBR2	Homo sapiens	P37173-2	Anti Bait CoIP	23868260
Intra	LRG1	P02750	TGFBR1	Homo sapiens	P36897-1	Anti Bait CoIP	23868260
Intra	LRG1	P02750	CYCS	Homo sapiens	P99999	Anti Tag CoIP	33961781
Intra	LRG1	P02750	CYCS	Homo sapiens	P99999	Anti Tag CoIP	28514442
Intra	LRG1	P02750	ACVRL1	Homo sapiens	P37023	Anti Bait CoIP	23868260

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LRG1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70166	LRG1 Protein, Human (HEK293, His)	AAH34389.1 (V36-Q347)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70175	LRG1 Protein, Human (HEK293, Fc-His)	P02750/AAH70198.1 (V36-Q347)	≥ 95%, as determined by reducing SDS-PAGE.

LRG1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82042	LRG1 Antibody (YA1787)	WB, IHC-P, IP	Human

Related Diseases

Diseases	Alias
Appendicitis	Acute Appendicitis Acute Appendicitis With Generalized Peritonitis Acute Appendicitis Nos Acute Appendicitis With Peritoneal Abscess Appendiceal Inflammation Appendicitis, Unqualified Acute Appendix Inflammation Acute Appendicitis With Diffuse Peritonitis Following Rupture Or Perforation Acute Appendicitis With Free Peritonitis Acute Appendicitis With Free Perforation To The Abdominal Cavity Perforated Appendix With Generalised Peritonitis Appendicitis With Perforation And Free Pus In The Peritoneal Cavity Perforated Appendix With Localised Peritonitis Acute Appendicitis With Contained Perforation To A Localised Abscess Acute Appendicitis With Localised Peritonitis With Rupture Or Perforation Acute Appendicitis With Localised Peritonitis Without Rupture Or Perforation Acute Appendicitis With Perforation And Contained Peritonitis Into An Abscess Appendicitis With Abscess Appendicitis With Peritoneal Abscess Ruptured Appendix Nos Acute Appendicitis With No Perforation Or Abscess And No Visible Pus Acute Appendicitis With No Specification If Perforated Or Not Acute Appendicitis With Phlegmone
Cecal Disease	Cecal Diseases Disorder Of Cecum
Communicating Hydrocephalus	Acquired Communicating Hydrocephalus
Hydrocephalus	Hydrocephalus, Nonsyndromic, Autosomal Recessive Hydrocephalus, X-Linked Hydrocephalus Adverse Event Hydrocephaly Nos
Normal Pressure Hydrocephalus	Low Pressure Hydrocephalus Hydrocephalus Normal Pressure Hydrocephalus, Normal Pressure Normal Pressure Hydrocephalus Nos Nph - [Normal Pressure Hydrocephalus] Normal Pressure Hydrocephaly
Cardiomyopathy, Dilated, 1e	Left Ventricular Noncompaction 9 Left Ventricular Noncompaction 5 Dilated Cardiomyopathy 1e Dilated Cardiomyopathy 1s CMD1E Cdcd2 Cardiomyopathy, Dilated, 1y CMD1Y Cardiomyopathy, Dilated, 1s CMD1S Dilated Cardiomyopathy 1y Dilated Cardiomyopathy With Conduction Defect 2 Dilated Cardiomyopathy With Conduction Disorder And Arrhythmia Cardiomyopathy, Dilated, With Conduction Disorder And Arrhythmia Cardiomyopathy, Dilated, With Conduction Defect 2 Cardiomyopathy Dilated With Conduction Defect Type 2 Cardiomyopathy, Dilated 1e Cardiomyopathy, Dilated 1s Cardiomyopathy, Dilated 1y Left Ventricular Non-Compaction 5 LVNC5 Left Ventricular Non-Compaction 9 LVNC9 Cardiomyopathy, Dilated, Type 1e Cardiomyopathy, Dilated, Type 1s Cardiomyopathy, Dilated, Type 1y
Cardiomyopathy, Familial Hypertrophic, 1	Asymmetric Septal Hypertrophy Familial Hypertrophic Cardiomyopathy Hypertrophic Cardiomyopathy 1 CMH1 Hypertrophic Cardiomyopathy 19 CMH Ventricular Hypertrophy, Hereditary Ash Hypertrophic Subaortic Stenosis, Idiopathic Cardiomyopathy, Familial Hypertrophic Cardiomyopathy, Hypertrophic, 1, Digenic Cardiomyopathy, Familial Hypertrophic 1 Hcm Hereditary Ventricular Hypertrophy Idiopathic Hypertrophic Subaortic Stenosis Hypertrophic Cardiomyopathy Cardiomyopathy, Hypertrophic, Familial Cardiomyopathy, Hypertrophic, 1 Familial Asymmetric Septal Hypertrophy Heritable Hypertrophic Cardiomyopathy Fhc Cardiomyopathy, Hypertrophic, Familial, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10899	ETTAC-2	Inhibitor	99.94%	Unkown
HY-RS16806	Lrg1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07784	LRG1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23246	Lrg1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LRG1	RGD	RGD:1359464
Macaca mulatta	LRG1	VGNC	VGNC:74394
Bos taurus	LRG1	VGNC	VGNC:30980
Felis catus	LRG1	VGNC	VGNC:102630
Canis familiaris	LRG1	VGNC	VGNC:42765
Mus musculus	LRG1	MGD	MGI:1924155
Others	LRG1	NCBI