36752-54-2
![[10]-Shogaol Chemical Structure](http://file.medchemexpress.cn/product_pic/hy-n2434.gif "[10]-Shogaol Chemical Structure")
Chemical Structure
[10]-Shogaol
- CAS No.: 36752-54-2
- Formula:C21H32O3
- Molecular Weight:332.48
IUPAC Name: (E)-1-(4-hydroxy-3-methoxyphenyl)tetradec-4-en-3-one
InChIKey: FADFGCOCHHNRHF-VAWYXSNFSA-N
SMILES: CCCCCCCCC/C=C/C(CCC1=CC=C(O)C(OC)=C1)=O
Biological Activity: [10]-Shogaol is an orally active antioxidant. [10]-Shogaol can be extracted from ginger (Zingiber officinale). [10]-Shogaol1 inhibits COX-2 with an IC50 value of 7.5 μM. [10]-Shogaol inhibits the production of proinflammatory cytokines (IL-1β, IL-6). [10]-Shogaol inhibits NF-κB phosphorylation. [10]-Shogaol has anti-inflammatory effects. [10]-Shogaol has anticancer effects against Docetaxel (HY-B0011)-resistant prostate cancer. [10]-Shogaol exhibits larvicidal activity against L5 larvae of Angiostrongylus cantonensis[1][2][3][4][5].
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[10]-Shogaol | 99.66% | -Shogaol is an orally active antioxidant. -Shogaol can be extracted from ginger (Zingiber officinale). -Shogaol1 inhibits COX-2 with an IC50 value of 7.5 μM. -Shogaol inhibits the production of proinflammatory cytokines (IL-1β, IL-6). -Shogaol inhibits NF-κB phosphorylation. -Shogaol has anti-inflammatory effects. -Shogaol has anticancer effects against Docetaxel (HY-B0011)-resistant prostate cancer. -Shogaol exhibits larvicidal activity against L5 larvae of Angiostrongylus cantonensis. | ||||||||||||||||||||
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[10]-Shogaol (Standard) | ≥98% | -Shogaol (Standard) is the analytical standard of -Shogaol (HY-N2434). This product is intended for research and analytical applications. -Shogaol is an orally active antioxidant. -Shogaol can be extracted from ginger (Zingiber officinale). -Shogaol1 inhibits COX-2 with an IC50 value of 7.5 μM. -Shogaol inhibits the production of proinflammatory cytokines (IL-1β, IL-6). -Shogaol inhibits NF-κB phosphorylation. -Shogaol has anti-inflammatory effects. -Shogaol has anticancer effects against Docetaxel (HY-B0011)-resistant prostate cancer. -Shogaol exhibits larvicidal activity against L5 larvae of Angiostrongylus cantonensis. | ||||||||||||||||||||
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- [1]. Chen CY, et al. 10-Shogaol, an antioxidant from Zingiber officinale for skin cell proliferation and migration enhancer. Int J Mol Sci. 2012;13(2):1762-77. [Content Brief]
- [2]. van Breemen RB, et al. Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale). Fitoterapia. 2011 Jan;82(1):38-43. [Content Brief]
- [3]. Liu CM, et al. Ginger Phytochemicals Inhibit Cell Growth and Modulate Drug Resistance Factors in Docetaxel Resistant Prostate Cancer Cell. Molecules. 2017 Sep 5;22(9). pii: E1477. [Content Brief]
Keywords
