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Cat. No.: HY-108909

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Chymopapain

Customer Review

Based on 1 Customer Validation

Chymopapain is a non-specific proteo-glycanase derived from the papaya plant. Chymopapain has neurotoxicity when injected into nerve bundles. Chymopapain directly into the intervertebral disc caused disc narrowing due to dissolution of the extruded material. Chymopapain has the potential for the research of herniated lumbar discs.

For research use only. We do not sell to patients.

CAS No.: 9001-09-6

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Chymopapain Chemical Structure

CAS No.: 9001-09-6

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Sample (0.1mg)

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(In Japan)

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
- EC Number
- Enzyme Activity
- Unit Definition
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All Endogenous Metabolite Isoforms :

In Vivo

Chymopapain (20-250 U, intraneural injection, single dose) causes dose-dependent nerve fiber damage in male Wistar rats^[2].
Chymopapain (100-10000 U, intraneural injection, single dose) causes nerve fiber damage at all doses in baboon^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EC Number

3.4.4.11

Enzyme Activity

≥800 U/mg soild

Unit Definition

One unit is defined as the amount of enzyme that will hydrolyzes casein substrate to produce an amount of enzyme equivalent to 1µg of tyrosine in 1 min at 37°C and pH 7.0.

Chemical Information

CAS No. 9001-09-6
Appearance Solid
Color White to off-white
SMILES

[Chymopapain]
Structure Classification
- Others
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage
mg/kg
Animal Weight (Per Animal)
g
Dosing Volume (Per Animal)
μL
Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Portuguese - PT (557 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Knezevic NN, et al. Treatment of chronic low back pain - new approaches on the horizon. J Pain Res. 2017 May 10;10:1111-1123. [Content Brief]

[2]. Mackinnon SE, et al. Peripheral nerve injury by chymopapain injection. J Neurosurg. 1984 Jul;61(1):1-8. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration

Volume

Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- In Vivo
- EC Number
- Enzyme Activity
- Unit Definition
Chemical Information
Solvent & Solubility
- In Vitro
- In Vivo Dissolution Calculator
Purity & Documentation
References

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