4 Results for "

ICD+inducer

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "ICD+inducer" in MCE Product Catalog:

ICD inducer-1
ICD inducer-1
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Cat. No.: HY-170884
Target:  

ER-phagy

연구분야:  

Cancer

ICD inducer-1 (Compound Re1) is an effective immunogenic cell death (ICD) inducer that can target the endoplasmic reticulum (ER) and block ER-phagy at the late stages. ICD inducer-1 is promising for research of cancers .
ICD inducer-2
ICD inducer-2
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Cat. No.: HY-181673
CAS No.: 3069681-35-9
Target:  

Microtubule/Tubulin Apoptosis Bcl-2 Family Caspase PARP

연구분야:  

Cancer

ICD inducer-2 is a immunogenic cell death inducer. ICD inducer-2 binds to the colchicine binding site on tubulin to inhibit tubulin polymerization. ICD inducer-2 exhibits broad-spectrum antiproliferative activity across multiple cancer cell lines. ICD inducer-2 inhibits cells migration, causes G2/M phase and induces apoptosis. ICD inducer-2 promotes infiltration of CD4+ and CD8+ T cells into the tumor microenvironment. ICD inducer-2 downregulates antiapoptotic protein Bcl-2, upregulates proapoptotic proteins Bax and Bim-1, and increases cleaved caspase 3, cleaved caspase 9, and cleaved PARP levels. ICD inducer-2 overcomes paclitaxel resistance in xenograft models and achieves tumor growth inhibition. ICD inducer-2 can be used for the research of cancer, such as lung carcinoma .
ROCK/HDAC-IN-1
ROCK/HDAC-IN-1
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Cat. No.: HY-168650
Target:  

ROCK HDAC

연구분야:  

Inflammation/Immunology Cancer

ROCK/HDAC-IN-1 (Compound 10h) is an orally active ROCK/HDAC inhibitor. ROCK/HDAC-IN-1 inhibits ROCK1/2 (IC50: 254.9 nM, 58.18 nM) and HDAC1/2/3/6/8 (IC50: 9.09, 8.03, 6.26, 0.41, 7.69 nM). ROCK/HDAC-IN-1 stimulates the activation of DAMPs, specifically Calreticulin (CRT) exposure and HMGB1 release, indicating that it is a potential ICD inducer.. ROCK/HDAC-IN-1 has antiproliferative activity against breast cancer cells (IC50: 0.37 μM for MDA-MB-231 cell), and inhibits tumor growth and activates T cells without apparent toxicity .
Pt(II)-NHC complex 2C
Pt(II)-NHC complex 2C
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Cat. No.: HY-175048
CAS No.: 3035433-94-1
Synonyms: Platinum(II)-N-heterocyclic carbene complex 2C
Target:  

Reactive Oxygen Species (ROS) Apoptosis ER-phagy

연구분야:  

Cancer

Pt(II)-NHC Complex 2C (Platinum(II)-N-Heterocyclic Carbene complex 2C) (Compound 2C) is a platinum(II) complex based on N-heterocyclic carbene (NHC). Pt(II)-NHC Complex 2C is an immunogenic cell death (ICD) inducer that can induce endoplasmic reticulum stress (ERS) in liver cancer cells and produce reactive oxygen species (ROS), ultimately leading to the release of damage-associated molecular patterns (DAMP). Pt(II)-NHC Complex 2C blocks the cell cycle at the S phase and significantly induces cell apoptosis. Pt(II)-NHC Complex 2C shows anti-liver cancer potential in mouse models and activates immune cells in liver injury models.
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