6 Results for "

MARCH

" in MedChemExpress (MCE) Product Catalog:
Products (6)

6 Results for "MARCH" in MCE Product Catalog:

Emodinanthrone
Emodinanthrone
0 Images
Art. -Nr.: HY-N9362
CAS. Nr.: 491-60-1
Synonyms: EmodAN
Category:  

Infection Phenols Polyphenols Plants Rhamnaceae Aconitum nagarum var. acaule (Finet & Gagnep.) Q. E. Yang Disease Research Fields

Target:  

Ferroptosis Antibiotic

Emodinanthrone (EmodAn) is a MARCH7 stabilizer that inhibits ferroptosis (EC50=70 nM). Emodinanthrone is also a precursor to Emodin (HY-14393) and possesses antibiotic activity. Emodinanthrone directly binds to MARCH7 and blocks its ubiquitination-mediated degradation at the K608 site; this action enhances MARCH7-mediated K48 ubiquitination and degradation of NCOA4, as well as its regulation of the intracellular localization of TFR1 via K63 ubiquitination, thereby reducing the intracellular labile iron pool and blocking ferroptosis. Emodinanthrone demonstrates in vivo cardioprotective effects and exhibits a favorable safety profile. Emodinanthrone is applicable to research on ferroptosis-related cardiovascular diseases, including Doxorubicin (HY-15142A)-induced cardiomyopathy and myocardial ischemia-reperfusion injury .
Emodinanthrone (Standard)
Emodinanthrone (Standard)
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Art. -Nr.: HY-N9362R
CAS. Nr.: 491-60-1
Synonyms: EmodAN (Standard)
Category:  

Phenols Polyphenols Plants Rhamnaceae Aconitum nagarum var. acaule (Finet & Gagnep.) Q. E. Yang

Target:  

Reference Standards Antibiotic Ferroptosis

Pro-xylane (Standard) is the analytical standard of Pro-xylane. This product is intended for research and analytical applications. Emodinanthrone (EmodAn) is a MARCH7 stabilizer that inhibits ferroptosis (EC50=70 nM). Emodinanthrone is also a precursor to Emodin (HY-14393) and possesses antibiotic activity. Emodinanthrone directly binds to MARCH7 and blocks its ubiquitination-mediated degradation at the K608 site; this action enhances MARCH7-mediated K48 ubiquitination and degradation of NCOA4, as well as its regulation of the intracellular localization of TFR1 via K63 ubiquitination, thereby reducing the intracellular labile iron pool and blocking ferroptosis. Emodinanthrone demonstrates in vivo cardioprotective effects and exhibits a favorable safety profile. Emodinanthrone is applicable to research on ferroptosis-related cardiovascular diseases, including Doxorubicin (HY-15142A)-induced cardiomyopathy and myocardial ischemia-reperfusion injury .
CEP55 Human Pre-designed siRNA Set A
CEP55 Human Pre-designed siRNA Set A
Art. -Nr.: HY-RS02517
Target:  

Small Interfering RNA (siRNA)

Forschungsgebiete:  

Others

CEP55 Human Pre-designed siRNA Set A contains three designed siRNAs for CEP55 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MARCH7 Antibody
MARCH7 Antibody
0 Images
Art. -Nr.: HY-P810527
Synonyms: AXOT, MARCH7, RNF177, MARCH-VII, Axotrophin, Membrane-associated RING finger protein 7, RING finger protein 177, RING-type E3 ubiquitin transferase MARCHF7

Host:  

Rabbit

Application:  

WB, IHC-P, IHC-F, ICC/IF

Reactivity:  

Human, Rat

MARCH9 Protein, Mouse (Cell-Free, His)
MARCH9 Protein, Mouse (Cell-Free, His)
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Art. -Nr.: HY-P7S1176
Reinheit:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MARCHf9; E3 ubiquitin-protein ligase MARCHF9; Membrane-associated RING finger protein 9; Membrane-associated RING-CH protein IX (MARCH-IX); RING-type E3 ubiquitin transferase MARCHF9
Species:  
Mouse
Source:  
E. coli Cell-free
MARCH2 Protein, Human (Cell-Free, His, SUMO)
MARCH2 Protein, Human (Cell-Free, His, SUMO)
0 Images
Art. -Nr.: HY-P702365
Reinheit:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: E3 ubiquitin-protein ligase MARCHF2; Membrane-associated RING finger protein 2; Membrane-associated RING-CH protein II; MARCH-II; RING finger protein 172; RING-type E3 ubiquitin transferase MARCHF2
Species:  
Human
Source:  
E. coli Cell-free
Assay Types