5 Results for "

ML-SIs

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "ML-SIs" in MCE Product Catalog:

8
ML-SI3
ML-SI3
0 Images
8 Publications Verification
Cat. No.: HY-139426
CAS No.: 891016-02-7
Pureté:  99.91%
Synonyms: ML-SI3 (cis/trans mix)
Target:  

Parasite TRP Channel

Domaines de recherche:  

Cardiovascular Disease Neurological Disease

ML-SI3 is a mixture of cis/trans ML-SI3 (HY-139426A), which is a TRPML1/2 channel inhibitor with IC50s of 4.7 μM and 1.7 μM, respectively. ML-SI3 also inhibits lysosomal calcium efflux and blocks downstream TRPML1-mediated autophagy. The cis/trans ML-SI3 (HY-139426A) components of ML-SI3 are TRPML2 activators with EC50s of 3.3 μM and 9.4 μM, respectively .
7
ML-SI1
ML-SI1
0 Images
7 Cited Publications
Cat. No.: HY-134818
Pureté:  99.80%
Target:  

TRP Channel

Domaines de recherche:  

Neurological Disease

ML-SI1, a racemic mixture of diastereomers, is a TRPML inhibitor with an IC50 value of 15 μM for TRPML1 .
3
(1R,2R)-ML-SI3
(1R,2R)-ML-SI3
0 Images
3 Cited Publications
Cat. No.: HY-134819A
CAS No.: 2418594-00-8
Pureté:  99.79%
Synonyms: (-)-trans-ML-SI3
Target:  

TRP Channel

Domaines de recherche:  

Neurological Disease

(1R,2R)-ML-SI3 is an isomer of ML-SI3 and a potent inhibitor of three isoforms of TRPML. (1R,2R)-ML-SI3 inhibits TRPMLs with IC50s of 1.6 μM (TRPML1), 2.3 μM (TRPML2), and 12.5 μM (TRPML3), respectively .
1
(rel)-ML-SI3
(rel)-ML-SI3
0 Images
1 Cited Publications
Cat. No.: HY-139426A
CAS No.: 2108567-79-7
Pureté:  99.81%
Synonyms: trans-ML-SI3
Target:  

TRP Channel Autophagy

Domaines de recherche:  

Cancer

(rel)-ML-SI3 is one of the active ingredients of ML-SI3 (HY-139426) (another component is (cis)-ML-SI3) that targets three isoforms of TRPML. (rel)-ML-SI3 is an inhibitor of TRPML1 and TRPML3 (IC50=3.1 μM/28.5 μM), and a potent activator of TRPML2 (EC50=3.3 μM) .
(1S,2S)-ML-SI3
(1S,2S)-ML-SI3
0 Images
Cat. No.: HY-134819
CAS No.: 2563870-87-9
Pureté:  99.68%
Synonyms: (+)-trans-ML-SI3
Target:  

TRP Channel

Domaines de recherche:  

Cancer

(1S,2S)-ML-SI3 is a trans-isomer of ML-SI3 that targets all three isoforms of TRPML. (1S,2S)-ML-SI3 is an activator of TRPML2 and TRPML3 (EC50=2.7 μM/10.8 μM) and a potent inhibitor of TRPML1 (IC50=5.9 μM) .
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