2563870-87-9
2563870-87-9
Chemical Structure
(1S,2S)-ML-SI3
Synonym(s): (+)-trans-ML-SI3
- CAS No.: 2563870-87-9
- Formula:C23H31N3O3S
- Molecular Weight:429.58
IUPAC Name: N-((1S,2S)-2-(4-(2-methoxyphenyl)piperazin-1-yl)cyclohexyl)benzenesulfonamide
InChIKey: OVTXOMMQHRIKGL-SFTDATJTSA-N
SMILES: COC1=CC=CC=C1N2CCN([C@H]3CCCC[C@@H]3NS(C4=CC=CC=C4)(=O)=O)CC2
Biological Activity: (1S,2S)-ML-SI3 is a trans-isomer of ML-SI3 that targets all three isoforms of TRPML. (1S,2S)-ML-SI3 is an activator of TRPML2 and TRPML3 (EC50=2.7 μM/10.8 μM) and a potent inhibitor of TRPML1 (IC50=5.9 μM)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(1S,2S)-ML-SI3 | 99.96% | (1S,2S)-ML-SI3 is a trans-isomer of ML-SI3 that targets all three isoforms of TRPML. (1S,2S)-ML-SI3 is an activator of TRPML2 and TRPML3 (EC50=2.7 μM/10.8 μM) and a potent inhibitor of TRPML1 (IC50=5.9 μM). | ||||||||||||||||||||
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References
Keywords
