9 Results for "

Sesn2

" in MedChemExpress (MCE) Product Catalog:
Products (9)

9 Results for "Sesn2" in MCE Product Catalog:

4
Isorhapontigenin
Isorhapontigenin
0 Images
4 Cited Publications
Cat. No.: HY-N2593
CAS No.: 32507-66-7
Category:  

Stilbenes Gnetum cleistostachyum C. Y. Cheng Gnetaceae Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Carnitine Palmitoyltransferase (CPT) Reactive Oxygen Species (ROS) Autophagy Apoptosis NF-κB PI3K Akt MMP Keap1-Nrf2

Isorhapontigenin is an orally active dietary polyphenol. Isorhapontigenin acts as a potent antioxidant that reduces the production of reactive oxygen species (ROS). Isorhapontigenin promotes the binding of JUN to the AP-1 site on the SESN2 promoter, induces SESN2 transcription, triggers MAPK8-dependent JUN activation, and upregulates the expression of PPAR-α, PGC-1α and CPT-1A to facilitate fatty acid oxidation. Isorhapontigenin induces autophagy, apoptosis and preadipocyte differentiation; it inhibits tumor growth, cell invasion, NF-κB transcriptional activity, the PI3K/Akt signaling pathway, STAT1 phosphorylation and MMP-2 expression. Isorhapontigenin alleviates oxidative stress, inflammatory cytokine release and triglyceride accumulation; it increases intracellular ATP levels and promotes Nrf2 nuclear translocation. Isorhapontigenin improves insulin sensitivity in adipose tissue and glucose tolerance, and reduces postprandial blood glucose, insulin and free fatty acid levels. Isorhapontigenin is applicable to research on bladder cancer, liver injury, chronic obstructive pulmonary disease, acute lung injury and type 2 diabetes [2] .
SESN2 Human Pre-designed siRNA Set A
SESN2 Human Pre-designed siRNA Set A
Cat. No.: HY-RS12735
Target:  

Small Interfering RNA (siRNA)

Research Areas:  

Others

SESN2 Human Pre-designed siRNA Set A contains three designed siRNAs for SESN2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sesn2 Mouse Pre-designed siRNA Set A
Sesn2 Mouse Pre-designed siRNA Set A
Cat. No.: HY-RS20488
Target:  

Small Interfering RNA (siRNA)

Research Areas:  

Others

Sesn2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sesn2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sesn2 Rat Pre-designed siRNA Set A
Sesn2 Rat Pre-designed siRNA Set A
Cat. No.: HY-RS26996
Target:  

Small Interfering RNA (siRNA)

Research Areas:  

Others

Sesn2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sesn2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Isorhapontigenin (Standard)
Isorhapontigenin (Standard)
0 Images
Cat. No.: HY-N2593R
CAS No.: 32507-66-7
Category:  

Stilbenes Gnetum cleistostachyum C. Y. Cheng Gnetaceae Phenols Polyphenols Plants

Target:  

Reference Standards Carnitine Palmitoyltransferase (CPT) Reactive Oxygen Species (ROS) Autophagy Apoptosis NF-κB PI3K Akt MMP Keap1-Nrf2

Isorhapontigenin (Standard) is the analytical standard of Isorhapontigenin (HY-N2593). This product is intended for research and analytical applications. Isorhapontigenin is an orally active dietary polyphenol. Isorhapontigenin acts as a potent antioxidant that reduces the production of reactive oxygen species (ROS). Isorhapontigenin promotes the binding of JUN to the AP-1 site on the SESN2 promoter, induces SESN2 transcription, triggers MAPK8-dependent JUN activation, and upregulates the expression of PPAR-α, PGC-1α and CPT-1A to facilitate fatty acid oxidation. Isorhapontigenin induces autophagy, apoptosis and preadipocyte differentiation; it inhibits tumor growth, cell invasion, NF-κB transcriptional activity, the PI3K/Akt signaling pathway, STAT1 phosphorylation and MMP-2 expression. Isorhapontigenin alleviates oxidative stress, inflammatory cytokine release and triglyceride accumulation; it increases intracellular ATP levels and promotes Nrf2 nuclear translocation. Isorhapontigenin improves insulin sensitivity in adipose tissue and glucose tolerance, and reduces postprandial blood glucose, insulin and free fatty acid levels. Isorhapontigenin is applicable to research on bladder cancer, liver injury, chronic obstructive pulmonary disease, acute lung injury and type 2 diabetes.
SESN2 Protein, Human (His)
SESN2 Protein, Human (His)
0 Images
Cat. No.: HY-P706141
Purity:  ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: Sestrin-2 Curated; EC:1.11.1.; Hypoxia-induced gene; Sesn2; Hi95; SEST2
Species:  
Human
Source:  
E. coli
SESN2 Antibody (YA5993)
SESN2 Antibody (YA5993)
0 Images
Cat. No.: HY-P86301
Synonyms: Sestrin-2; Hi95;

Host:  

Rabbit

Application:  

WB, ICC/IF, IP, ELISA

Reactivity:  

Human, Mouse, Rat

SESN2 Antibody (YA1934)
SESN2 Antibody (YA1934)
0 Images
Cat. No.: HY-P82189
Synonyms: HI95; SES2; SEST2

Host:  

Rabbit

Application:  

WB, ICC/IF, IP

Reactivity:  

Human, Mouse, Rat

SESN2 Antibody (YA1934)(PBS only)
SESN2 Antibody (YA1934)(PBS only)
0 Images
Cat. No.: HY-P82189A
Synonyms: HI95; SES2; SEST2

Host:  

Rabbit

Application:  

WB, ICC/IF, IP

Reactivity:  

Human, Mouse, Rat

Assay Types