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Isoforms Recommended:	VDAC2

Results for "

VDAC2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	VDAC (4) Apoptosis (2) Bcl-2 Family (1) Disulfidptosis (1) Ferroptosis (1) PERK (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (4)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Oligonucleotides

Targets Recommended: VDAC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15763

Erastin 800+ Cited Publications	VDAC Ferroptosis Disulfidptosis	Cancer
Erastin is a ferroptosis inducer. Erastin exhibits the mechanism of ferroptosis induction related to ROS and iron-dependent signaling. Erastin inhibits voltage-dependent anion channels (VDAC2/VDAC3) and accelerates oxidation, leading to the accumulation of endogenous reactive oxygen species. Erastin also disrupts mitochondrial permeability transition pore (mPTP) with anti-tumor activity. Furthermore, Erastin can block the uptake of cystine mediated by SLC7A11 and also spares UMRC6-EV and -C91A cells from disulfidptosis under glucose starvation ^[2] .

HY-172262

WEHI-3773	VDAC Bcl-2 Family Apoptosis	Cancer
WEHI-3773 is a *VDAC2* ligand and apoptosis modulator. WEHI-3773 directly binds to the β7-β10 region of VDAC2 and disrupts its interaction with BAX and BAK. WEHI-3773 regulates BAX-mediated apoptosis in BAK-deficient cells by modulating conformational activation of BAX, mitochondrial redistribution, and cytochrome c release. WEHI-3773 overcomes Venetoclax (HY-15531) resistance, resensitizes leukemia cells carrying BAX mutations to BH3 mimetics, and enables long-term clonogenic survival of BAK-deficient cells treated with BH3 mimetics. WEHI-3773 is applicable to research related to acute myeloid leukemia ^[2].

HY-128777

WEHI-9625 1 Publications Verification	VDAC Apoptosis	Cancer
WEHI-9625 is a tricyclic sulfone, first-in-class inhibitor of apoptosis with an EC₅₀ of 69 nM. WEHI-9625 binds to *VDAC2* and promotes its ability to inhibit apoptosis driven by mouse BAK. WEHI-9625 is completely inactive against both human BAK and the closely related apoptosis effector BAX .

HY-RS15630

VDAC2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
VDAC2 Human Pre-designed siRNA Set A contains three designed siRNAs for VDAC2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

VDAC2 Human Pre-designed siRNA Set A VDAC2 Human Pre-designed siRNA Set A

HY-RS17560

Vdac2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Vdac2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Vdac2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Vdac2 Mouse Pre-designed siRNA Set A Vdac2 Mouse Pre-designed siRNA Set A

HY-RS24018

Vdac2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Vdac2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Vdac2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Vdac2 Rat Pre-designed siRNA Set A Vdac2 Rat Pre-designed siRNA Set A

HY-181529

NCATS-SM0225	VDAC PERK	Cancer
NCATS-SM0225 is an endoplasmic reticulum-associated degradation (ERAD) inhibitor and a direct binder of *VDAC1, VDAC2* and *VDAC3. NCATS-SM0225 exhibits an IC₅₀of 1.02 μM for ERAD and a K_d* of 3.13 μM for human VDAC1 binding. NCATS-SM0225 disrupts cellular calcium homeostasis, enhances *VDAC1-IP3R* coupling and activating PERK. NCATS-SM0225 selectively kills cancer cells, exhibits tumor growth inhibitory effects in melanoma xenograft models. NCATS-SM0225 can be used for research on multiple cancers including melanoma, as well as the molecular mechanisms of ERAD and calcium homeostasis regulation .

VDAC2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
VDAC2 Human Pre-designed siRNA Set A contains three designed siRNAs for VDAC2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Vdac2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Vdac2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Vdac2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Vdac2 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Vdac2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Vdac2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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