6 Results for "

kinesin+5

" in MedChemExpress (MCE) Product Catalog:
Products (6)

6 Results for "kinesin+5" in MCE Product Catalog:

1
BRD9876
BRD9876
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1 Cited Publications
Cat. No.: HY-110208
CAS No.: 32703-82-5
Purity:  98.82%
Target:  

Kinesin Microtubule/Tubulin

Research Areas:  

Cancer

BRD9876 is the “rigor” inhibitor that locks kinesin-5 (Eg5) in a state with enhanced microtubules (MTs) binding, leading to bundling and stabilization of MTs. BRD9876 interacts with the tyrosine 104 residue that is part of the α4-α6 allosteric binding pocket. BRD9876 specifically targets microtubule-bound Eg5 and selectively inhibits myeloma over CD34 cells. BRD9876 has the potential for multiple myeloma (MM) research .
EMD534085
EMD534085
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Cat. No.: HY-15000
CAS No.: 858668-07-2
Purity:  99.55%
Target:  

Kinesin

Research Areas:  

Cancer

EMD534085 is a potent and selective inhibitor of the mitotic kinesin-5 with an IC50 of 8 nM.
PVZB1194
PVZB1194
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Cat. No.: HY-122247
CAS No.: 1141768-04-8
Purity:  99.90%
Target:  

Kinesin

Research Areas:  

Cancer

PVZB1194 is a biphenyl-type inhibitor of Kinesin-5 ATPase activity that binds to the α4/α6 site of the motor domain in a nucleotide competitive manner. PVZB1194 has an IC50 of 0.12 μM for KSP ATPase. PVZB1194 induces mitotic arrest with the formation of a monopolar spindle, and inhibits HeLa cells proliferatio (IC50: 5.5 μM). PVZB1194 can be used in the study of tumors .
FCPT
FCPT
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Cat. No.: HY-121908
CAS No.: 862250-23-5
Target:  

ATP Synthase

Research Areas:  

Cancer

FCPT, an ATP competitive inhibitor, induces a tight-binding of kinesin-5 onto microtubules and induced loss of microtubules selectively at the poles of Xenopus extract spindles without altering microtubule dynamics .
AZD4877 hydrochloride
AZD4877 hydrochloride
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Cat. No.: HY-13224A
CAS No.: 758722-12-2
Target:  

Endogenous Metabolite

Research Areas:  

Cancer

AZD4877 hydrochloride is a synthetic dynein inhibitor with potential anti-tumor activity. AZD4877 selectively inhibits the microtubule dynein KSP (also known as kinesin-5 or Eg5), which may lead to inhibition of mitotic spindle assembly. The action of AZD4877 may activate the spindle assembly checkpoint, leading to cell cycle arrest at the mitotic stage. AZD4877 may induce cell death in actively dividing tumor cells. AZD4877 may be less likely to cause peripheral neuropathy associated with microtubule-targeted compounds as it is not involved in post-mitotic processes. AZD4877 is essential for the formation of bipolar spindles and the proper segregation of sister chromosomes .
NSC-80141
NSC-80141
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Cat. No.: HY-129302
CAS No.: 97027-56-0
Target:  

Kinesin

Research Areas:  

Infection

NSC-80141 is a Kinesin-5 inhibitor. NSC-80141 exerts selective inhibitory activity against human kinesin-5 (HsEg5) (IC50: 9.4 μM), while shows weak inhibitory activity against Plasmodium kinesin-5 (PvEg5) (IC50: 27.3 μM). NSC-80141 serves as a tool compound for distinguishing human and Plasmodium homologous proteins .
Assay Types