1141768-04-8
1141768-04-8
Chemical Structure
PVZB1194
- CAS No.: 1141768-04-8
- Formula:C13H9F4NO2S
- Molecular Weight:319.27
IUPAC Name: 3'-fluoro-4'-(trifluoromethyl)-[1,1'-biphenyl]-4-sulfonamide
InChIKey: UEPKMFLFRNDVAW-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(C2=CC=C(C(F)(F)F)C(F)=C2)C=C1)(N)=O
Biological Activity: PVZB1194 is a biphenyl-type inhibitor of Kinesin-5 ATPase activity that binds to the α4/α6 site of the motor domain in a nucleotide competitive manner. PVZB1194 has an IC50 of 0.12 μM for KSP ATPase. PVZB1194 induces mitotic arrest with the formation of a monopolar spindle, and inhibits HeLa cells proliferatio (IC50: 5.5 μM). PVZB1194 can be used in the study of tumors[1][2].
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PVZB1194 | 99.64% | PVZB1194 is a biphenyl-type inhibitor of Kinesin-5 ATPase activity that binds to the α4/α6 site of the motor domain in a nucleotide competitive manner. PVZB1194 has an IC50 of 0.12 μM for KSP ATPase. PVZB1194 induces mitotic arrest with the formation of a monopolar spindle, and inhibits HeLa cells proliferatio (IC50: 5.5 μM). PVZB1194 can be used in the study of tumors. | ||||||||||||||||||||
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References
- [1]. Sawada JI, et al. Various effects of two types of kinesin-5 inhibitors on mitosis and cell proliferation. Biochem Pharmacol. 2021 Nov;193:114789. [Content Brief]
- [2]. Matsuno K, et al. Bis(hetero)aryl derivatives as unique kinesin spindle protein inhibitors. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1058-61. [Content Brief]
