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ADAMTSL3 - ADAMTS like 3 Gene

Also Known as ADAMTSL-3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57188

About ADAMTSL3

Cytogenetic location: 15q25.2 Genomic coordinates (GRCh38): 15:83,654,123-84,039,842 (from NCBI)

This gene has 8 transcripts (splice variants), 193 orthologues and 25 paralogues. Broad expression in lung (RPKM 4.5), placenta (RPKM 4.0) and 24 other tissues.

Summary

Predicted to be involved in extracellular matrix organization. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]

ADAMTSL3 Products (2)

mRNA	Protein	Name
NM_001301110.2	NP_001288039.1	ADAMTS-like protein 3 isoform b precursor
NM_207517.3	NP_997400.2	ADAMTS-like protein 3 isoform a precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADAMTSL3 Protein Structure

TSP_1

Ig_2

I-set

TSP_1

PLAC

0
300
600
900
1200
1500
1691 a.a.

Protein Preferred Names	Protein Names
ADAMTS-like protein 3	a disintegrin-like and metalloprotease domain with thrombospondin type I motifs-like 3

ADAMTSL3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ADAMTSL3	P82987	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	ADAMTSL3	P82987	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	ADAMTSL3	P82987	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	ADAMTSL3	P82987	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	25416956
Intra	ADAMTSL3	P82987	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	ADAMTSL3	P82987	KRTAP2-3	Homo sapiens	P0C7H8	Validated Y2H	25416956
Intra	ADAMTSL3	P82987	KRTAP12-3	Homo sapiens	P60328	Y2H Array	32296183
Intra	ADAMTSL3	P82987	KRTAP12-3	Homo sapiens	P60328	Y2H Prey Pooling	32296183
Intra	ADAMTSL3	P82987	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	ADAMTSL3	P82987	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	ADAMTSL3	P82987	KRTAP1-1	Homo sapiens	Q07627	Validated Y2H	32296183
Intra	ADAMTSL3	P82987	KRTAP5-7	Homo sapiens	Q6L8G8	Validated Y2H	32296183
Intra	ADAMTSL3	P82987	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Array	32296183
Intra	ADAMTSL3	P82987	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Prey Pooling	32296183
Intra	ADAMTSL3	P82987	KRTAP10-6	Homo sapiens	P60371	Y2H Prey Pooling	32296183
Intra	ADAMTSL3	P82987	KRTAP10-6	Homo sapiens	P60371	Y2H Array	32296183
Intra	ADAMTSL3	P82987	KRTAP2-4	Homo sapiens	Q9BYR9	Y2H Array	32296183
Intra	ADAMTSL3	P82987	KRTAP2-4	Homo sapiens	Q9BYR9	Validated Y2H	32296183
Intra	ADAMTSL3	P82987	KRTAP2-4	Homo sapiens	Q9BYR9	Y2H Prey Pooling	32296183
Intra	ADAMTSL3	P82987	GLRX3	Homo sapiens	O76003	Y2H Prey Pooling	32296183
Intra	ADAMTSL3	P82987	GLRX3	Homo sapiens	O76003	Y2H Array	32296183
Intra	ADAMTSL3	P82987	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	ADAMTSL3	P82987	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	ADAMTSL3	P82987	MDFI	Homo sapiens	Q99750	Validated Y2H	25416956
Intra	ADAMTSL3	P82987	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	ADAMTSL3	P82987	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
Intra	ADAMTSL3	P82987	MDFI	Homo sapiens	Q99750	Y2H Array	25416956
Intra	ADAMTSL3	P82987	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	ADAMTSL3	P82987	KRTAP3-2	Homo sapiens	Q9BYR7	Validated Y2H	32296183
Intra	ADAMTSL3	P82987	KRTAP3-2	Homo sapiens	Q9BYR7	Y2H Array	32296183
Intra	ADAMTSL3	P82987	KRTAP3-2	Homo sapiens	Q9BYR7	Y2H Prey Pooling	32296183
Intra	ADAMTSL3	P82987	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956
Intra	ADAMTSL3	P82987	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Radial Nerve Lesion	Lesion Of Radial Nerve Radial Nerve Lesions Radial Neuropathy Radial Nerve Mononeuritis
Geleophysic Dysplasia	Geleophysic Dwarfism Gphysd
Isolated Ectopia Lentis	Familial Ectopia Lentis Ectopia Lentis Ectopia Lentis Syndrome Lens Subluxation Iel Congenital Ectopia Lentis Subluxation Of Lens Ectopia Lentis, Isolated Ectopia Lentis Isolated
Ehlers-Danlos Syndrome, Dermatosparaxis Type	Dermatosparaxis EDSDERMS Ehlers-Danlos Syndrome, Type Vii, Autosomal Recessive Eds Viic Eds7c Ehlers-Danlos Syndrome Dermatosparaxis Type Dermatosparaxis Ehlers-Danlos Syndrome Dermatosparaxis Eds Ehlers-Danlos Syndrome Type 7c Deds Human Dermatosparaxis Eds Viic Ehlers-Danlos Syndrome 7c Ehlers-Danlos Syndrome, Type Viic
Weill-Marchesani Syndrome	Gemss Syndrome Spherophakia-Brachymorphia Syndrome Marchesani-Weill Syndrome Wms Congenital Mesodermal Dystrophy Mesodermal Dysmorphodystrophy, Congenital Spherophakia Brachymorphia Syndrome Mesodermal Dysmorphodystrophy Congenital Wm Syndrome Brachydactyly-Spherophakia Syndrome Brachymorphy With Spherophakia Syndrome Congenital Mesodermal Dysmorphodystrophy Marchesani Syndrome Weill-Marchesani Syndrome, Autosomal Recessive Weill-Marchesani Syndrome, Autosomal Dominant
Peters-Plus Syndrome	Krause-Kivlin Syndrome Peters Plus Syndrome Peters Anomaly Irido-Corneo-Trabecular Dysgenesis PTRPLS Peters Anomaly With Short-Limb Dwarfism Peters Anomaly-Short Limb Dwarfism Syndrome Peters Anomaly With Short Limb Dwarfism Peters Congenital Glaucoma Krause-Van Schooneveld-Kivlin Syndrome Peters' Plus Syndrome Peters'-Plus Syndrome Anomaly Peters
Radial Neuropathy
Acromicric Dysplasia	ACMICD Acromicric Skeletal Dysplasia Dysplasia, Acromicric
Winchester Syndrome	WNCHRS Winchester Disease Winchester-Grossman Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00312	ADAMTSL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ADAMTSL3	RGD	RGD:1305155
Macaca mulatta	ADAMTSL3	VGNC	VGNC:69400
Felis catus	ADAMTSL3	VGNC	VGNC:59601
Bos taurus	ADAMTSL3	VGNC	VGNC:58360
Canis familiaris	ADAMTSL3	VGNC	VGNC:54916
Mus musculus	ADAMTSL3	MGD	MGI:3028499
Others	ADAMTSL3	NCBI