IL-11 Receptor
IL-11 receptor is a type-I transmembrane protein, binding to interleukin 11. The IL-11 receptor comprises IL-11Rα and an incompletely characterized beta subunit[1]. IL-11 binds to IL-11 receptor and induces gp130 homodimerization, activates several intracellular signaling cascades, among them the Janus kinase/signal transducer and activator of transcription (Jak/STAT), the phosphoinositide 3-kinase (PI3K), and the mitogen-activated protein kinase (MAPK) pathway[2].
- [1]. Nishina T, et al. Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer. Nat Commun. 2021 Apr 16;12(1):2281. [Content Brief]
- [2]. Koch L, et al. Interleukin-11 (IL-11) receptor cleavage by the rhomboid protease RHBDL2 induces IL-11 trans-signaling. FASEB J. 2021 Mar;35(3):e21380. [Content Brief]
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IL-11 Receptor Recombinant Proteins (8)
- Species:
- Source:
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- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
