2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. MAC glucuronide α-hydroxy lactone-linked SN-38

MAC glucuronide α-hydroxy lactone-linked SN-38 

Cat. No.: HY-128942
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MAC glucuronide α-hydroxy lactone-linked SN-38 (Topoisomerase I inhibitor) is a stabilized lactone MAC glucuronide α-hydroxy lactone-linked SN-38 agent linker. MAC glucuronide α-hydroxy lactone-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC50 values of 99 and 105 ng/mL, respectively.

For research use only. We do not sell to patients.

MAC glucuronide α-hydroxy lactone-linked SN-38 Chemical Structure

MAC glucuronide α-hydroxy lactone-linked SN-38 Chemical Structure

CAS No. : 2246380-70-9

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MAC glucuronide α-hydroxy lactone-linked SN-38 Related Antibodies

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View All Drug-Linker Conjugates for ADC Isoform Specific Products:

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Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

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Description

MAC glucuronide α-hydroxy lactone-linked SN-38 (Topoisomerase I inhibitor) is a stabilized lactone MAC glucuronide α-hydroxy lactone-linked SN-38 agent linker. MAC glucuronide α-hydroxy lactone-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC50 values of 99 and 105 ng/mL, respectively[1].

IC50 & Target

Camptothecins

 

Molecular Weight

1091.06

Formula

C50H54N6O20S
CAS No.
SMILES

O=C([C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC2=CC=C(COC(N(CO[C@](C3=C(CO4)C(N5CC6=C(CC)C7=CC(O)=CC=C7N=C6C5=C3)=O)(CC)C4=O)CCS(=O)(C)=O)=O)C=C2NC(CN(C)C(CCN8C(C=CC8=O)=O)=O)=O)O1)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MAC glucuronide α-hydroxy lactone-linked SN-38 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAC glucuronide α-hydroxy lactone-linked SN-382246380-70-9Drug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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