1. Antibody-drug Conjugate/ADC Related
  2. Drug-Linker Conjugates for ADC
  3. Stabilized lactone

Stabilized lactone 

Cat. No.: HY-128942
Handling Instructions

Stabilized lactone (Drug linker 2) is a stabilized lactone-linked SN-38 drug linker. Stabilized lactone is cytotoxic across L540cy cells and Ramos cells with IC50 values of 99 and 105 ng/mL, respectively.

For research use only. We do not sell to patients.

Stabilized lactone Chemical Structure

Stabilized lactone Chemical Structure

CAS No. : 2246380-70-9

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Description

Stabilized lactone (Drug linker 2) is a stabilized lactone-linked SN-38 drug linker. Stabilized lactone is cytotoxic across L540cy cells and Ramos cells with IC50 values of 99 and 105 ng/mL, respectively[1].

Molecular Weight

1091.06

Formula

C₅₀H₅₄N₆O₂₀S

CAS No.

2246380-70-9

SMILES

O=C([[email protected]@H]1[[email protected]@H](O)[[email protected]](O)[[email protected]@H](O)[[email protected]](OC2=CC=C(COC(N(CO[[email protected]](C3=C(CO4)C(N5CC6=C(CC)C7=CC(O)=CC=C7N=C6C5=C3)=O)(CC)C4=O)CCS(=O)(C)=O)=O)C=C2NC(CN(C)C(CCN8C(C=CC8=O)=O)=O)=O)O1)O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Stabilized lactone
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