UNG - uracil DNA glycosylase Gene

Also Known as DGU; UDG; UNG1; UNG2; HIGM4; HIGM5; UNG15

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7374

About UNG

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:109,097,597-109,110,992 (from NCBI)

This gene has 14 transcripts (splice variants), 223 orthologues and is associated with 2 phenotypes. Ubiquitous expression in adrenal (RPKM 23.4), testis (RPKM 16.9) and 25 other tissues.

Summary

This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil Bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010]

UNG Products (2)

mRNA	Protein	Name
NM_003362.4	NP_003353.1	uracil-DNA glycosylase isoform UNG1 precursor
NM_080911.3	NP_550433.1	uracil-DNA glycosylase isoform UNG2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables damaged DNA binding	IDA IDA: Inferred from direct assay	18973764	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10982866	GOA
enables ribosomal small subunit binding	IPI IPI: Inferred from physical interaction	18973764	GOA
enables uracil DNA N-glycosylase activity	IDA IDA: Inferred from direct assay	12161446	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in base-excision repair	IDA IDA: Inferred from direct assay	12161446	GOA
involved in base-excision repair, AP site formation via deaminated base removal	IDA IDA: Inferred from direct assay	18973764	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleoplasm	IDA IDA: Inferred from direct assay	12161446	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UNG Protein Structure

UDG

0
100
200
313 a.a.

Protein Preferred Names	Protein Names
uracil-DNA glycosylase	uracil-DNA glycosylase 1, uracil-DNA glycosylase 2

UNG Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	UNG	P13051	RPA2	Homo sapiens	P15927	NMR	24910198
Intra	UNG	P13051	RPA2	Homo sapiens	P15927	Y2H	10982866
Intra	UNG	P13051	RPA2	Homo sapiens	P15927	ITC	24910198

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UNG Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73562	UNG Protein, Human (His)	P13051-2 (F85-L304)	≥ 95%, as determined by reducing SDS-PAGE.

UNG Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82853	Uracil DNA Glycosylase Antibody (YA2598)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Immunodeficiency With Hyper-Igm, Type 5	HIGM5 Hyper-Igm Syndrome 5 Immunodeficiency With Hyper Igm Type 5 Hyper-Igm Syndrome Type 5 Hyper-Igm Syndrome Due To Ung Deficiency Hyper-Igm Syndrome Due To Uracil N-Glycosylase Immunodeficiency With Hyper Igm, Type 5 Hyper Igm Syndrome 5 Immunodeficiency With Hyper-Igm 5 Hyper-Igm Immunodeficiency Type 5 Immunodeficiency, With Hyper Igm, Type 5 Hyper-Igm Immunodeficiency Syndrome, Type 5
Immunodeficiency With Hyper-Igm, Type 1	Immunodeficiency, X-Linked, With Hyper-Igm Hyper Igm Syndrome HIGM1 Xhim Hyper-Igm Syndrome Higm Hyper-Igm Syndrome 1 Immunodeficiency 3 Imd3 Immunodeficiency With Hyper-Igm Immunodeficiency With Hyper Igm Type 1 Ihis X-Linked Hyper Igm Syndrome Hyper-Igm Immunodeficiency, X-Linked Hyper Igm Immunodeficiency, X-Linked Hyper Igm Syndrome 1 X-Linked Immunodeficiency With Hyper-Igm 1 Immunodeficiency, With Hyper Igm Immunodeficiency, With Hyper Igm, Type 1 Hyper-Igm Immunodeficiency Syndrome, Type 1 Hyperimmunoglobulin M Syndrome
Immunodeficiency With Hyper-Igm, Type 4	HIGM4 Hyper-Igm Syndrome Type 4 Immunodeficiency With Hyper-Igm Type 4 Hyper-Igm Syndrome 4 Immunodeficiency With Hyper Igm Type 4 Hyper Igm Syndrome 4 Immunodeficiency, With Hyper Igm, Type 4
Immunodeficiency With Hyper-Igm, Type 2	HIGM2 Hyper-Igm Syndrome Type 2 Hyper-Igm Syndrome 2 Immunodeficiency With Hyper-Igm Type 2 Activation-Induced Cytidine Deaminase Deficiency Aid Deficiency Immunodeficiency With Hyper Igm Type 2 Hyper Igm Syndrome 2 Immunodeficiency With Hyper-Igm 2 Hyper-Igm Immunodeficiency Type 2 Immunodeficiency, With Hyper Igm, Type 2 Hyper-Igm Immunodeficiency Syndrome, Type 2
Immunodeficiency 25	Immunodeficiency Due To Defect In Cd3-Zeta IMD25 Immunodeficiency, Type 25
Spinocerebellar Ataxia Type 1 With Axonal Neuropathy	Scan1 Spinocerebellar Ataxia With Axonal Neuropathy Type 1 Autosomal Recessive Spinocerebellar Ataxia With Axonal Neuropathy Scan1, Tdp1-Related Spinocerebellar Ataxia With Axonal Neuropathy Spinocerebellar Ataxia Autosomal Recessive With Axonal Neuropathy Spinocerebellar Ataxia With Axonal Neuropathy Spinocerebellar Ataxia, Autosomal Recessive, With Axonal Neuropathy Ataxia, Spinocerebellar, Autosomal Recessive With Axonal Neuropathy
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis Xp De Sanctis-Cacchione Syndrome Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum
Ichthyosis, Congenital, Autosomal Recessive 11	Autosomal Recessive Congenital Ichthyosis 11 Ichthyosis With Hypotrichosis, Autosomal Recessive Arih Ichthyosis And Follicular Atrophoderma With Hypotrichosis And Hypohidrosis Autosomal Recessive Ichthyosis With Hypotrichosis ARCI11 Ifah Hypotrichosis-Congenital Ichthyosis Syndrome Ichthyosis-Follicular Atrophoderma-Hypotrichosis Syndrome Ichthyosis-Follicular Atrophoderma-Hypotrichosis-Hypohidrosis Syndrome Ichthyosis-Hypotrichosis Syndrome Ifah Syndrome Ihs
Ovarian Clear Cell Adenocarcinoma
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Cockayne Syndrome A	Cockayne Syndrome Type 1 Cockayne Syndrome, Type A Cockayne Syndrome Type I CSA Cockayne Syndrome Classic Form Cockayne Syndrome Classical Cockayne Syndrome Type A Ckn1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-E70217	Uracil DNA Glycosylase (UDG/UNG), heat-sensitive		/	Unkown
HY-RS15478	UNG Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-112333	SC-68376	Inhibitor	/	Unkown
HY-RS18026	Ung Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24499	Ung Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	UNG	RGD	RGD:1307200
Canis familiaris	UNG	VGNC	VGNC:48147
Macaca mulatta	UNG	VGNC	VGNC:78725
Felis catus	UNG	VGNC	VGNC:80543
Mus musculus	UNG	MGD	MGI:109352
Bos taurus	UNG	VGNC	VGNC:36677
Others	UNG	NCBI