Liproxstatin-1 hydrochloride
Based on 235 publication(s) in Google Scholar
Liproxstatin-1 hydrochloride is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC50=22 nM).
For research use only. We do not sell to patients.
- Purity: 99.31%
- CAS No.: 2250025-95-5
- Formula: C19H22Cl2N4
- Molecular Weight:377.31
-
Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Liproxstatin-1 hydrochloride
More- Signal Transduct Target Ther. 2025 Dec 26;10(1):420. [Abstract]
- Signal Transduct Target Ther. 2025 Dec 17;10(1):413. [Abstract]
- Cell. 2025 Aug 21;188(17):4567-4585.e32. [Abstract]
- Cell Stem Cell. 2024 Aug 21:S1934-5909(24)00285-6. [Abstract]
- Bioact Mater. 2021 Nov 19;13:23-36. [Abstract]
- Nat Cell Biol. 2026 Apr;28(4):783-796. [Abstract]
- Cancer Res. 2025 Aug 29. [Abstract]
- Mol Cell. 2025 Aug 7;85(15):2973-2987.e6. [Abstract]
- Cancer Res. 2023 May 15;83(10):1646-1665. [Abstract]
- Nat Commun. 2026 May 11;17(1):4190. [Abstract]
- Nat Commun. 2025 Dec 8. [Abstract]
- Nat Commun. 2025 Nov 18;16(1):10096. [Abstract]
- Nat Commun. 2023 Mar 17;14(1):1430. [Abstract]
- Cell Death Differ. 2025 Jun;32(6):1071-1085. [Abstract]
- Cell Death Differ. 2025 Jun;32(6):1041-1057. [Abstract]
- Cell Death Differ. 2025 Mar;32(3):506-520. [Abstract]
- Cell Death Differ. 2025 Feb;32(2):242-255. [Abstract]
- Adv Sci (Weinh). 2025 Jan 31:e2408845. [Abstract]
- Adv Sci (Weinh). 2024 Mar;11(12):e2307870. [Abstract]
- Adv Sci (Weinh). 2023 Dec;10(36):e2303812. [Abstract]
- Adv Sci (Weinh). 2023 Sep;10(25):e2301088. [Abstract]
- Adv Sci (Weinh). 2023 Aug;10(24):e2300881. [Abstract]
- J Clin Invest. 2025 Apr 3:e190841. [Abstract]
- J Clin Invest. 2024 Jan 23;134(6):e171166. [Abstract]
- Theranostics. 2024 Jul 2;14(10):4090-4106. [Abstract]
- Theranostics. 2021 Aug 4;11(18):8674-8691. [Abstract]
- Chem Eng J. 2023 Oct 17, 146749.
- J Adv Res. 2026 Mar 12:S2090-1232(26)00234-1. [Abstract]
- Exp Mol Med. 2025 Nov;57(11):2686-2698. [Abstract]
- Biomaterials. 2024 Jan:304:122430. [Abstract]
- J Nanobiotechnology. 2025 Oct 16;23(1):684. [Abstract]
- Small. 2021 Aug;17(32):e2101368. [Abstract]
- Redox Biol. 2026 Apr:91:104088. [Abstract]
- Redox Biol. 2026 Mar:90:104034. [Abstract]
- Redox Biol. 2026 Mar:90:104043. [Abstract]
- Redox Biol. 2025 May 8:84:103657. [Abstract]
- Redox Biol. 2025 Feb 3:80:103528. [Abstract]
- Redox Biol. 2024 Nov 5:78:103419. [Abstract]
- Redox Biol. 2024 Dec 5:79:103460. [Abstract]
- Redox Biol. 2024 Sep:75:103270. [Abstract]
- Redox Biol. 2024 May 23:73:103207. [Abstract]
- Redox Biol. 2019 Jun:24:101211. [Abstract]
- J Hazard Mater. 2024 Dec 5:480:135952. [Abstract]
- Research (Wash D C). 2024 Aug 19:7:0457. [Abstract]
- MedComm. 2024 Apr 4;5(4):e520. [Abstract]
- Cell Mol Biol Lett. 2025 Oct 2;30(1):109. [Abstract]
- Int J Biol Sci. 2025 Jan 1;21(1):189-203. [Abstract]
- Food Chem. 2023 May 15:408:135249. [Abstract]
- J Colloid Interface Sci. 2025 Jun 12;699(Pt 1):138178. [Abstract]
- J Colloid Interface Sci. 2024 Aug:667:91-100. [Abstract]
- J Colloid Interface Sci. 2024 Jan;653(Pt A):20-29. [Abstract]
- Cell Death Dis. 2025 Nov 17;16(1):843. [Abstract]
- Cell Death Dis. 2025 May 21;16(1):407. [Abstract]
- Cell Death Dis. 2024 Oct 5;15(10):729. [Abstract]
- Cell Death Dis. 2023 Mar 11;14(3):193. [Abstract]
- Cell Death Dis. 2023 Jan 26;14(1):61. [Abstract]
- Cell Death Dis. 2022 Sep 26;13(9):825. [Abstract]
- Cell Death Dis. 2022 Jul 28;13(7):653. [Abstract]
- Cell Death Dis. 2022 May 20;13(5):479. [Abstract]
- Cell Death Dis. 2021 Sep 11;12(9):843. [Abstract]
- Cell Death Dis. 2020 Mar 13;11(3):183. [Abstract]
- Sci China Life Sci. 2023 Aug;66(8):1800-1817. [Abstract]
- Acta Pharmacol Sin. 2024 Aug;45(8):1715-1726. [Abstract]
- Acta Pharmacol Sin. 2021 Feb;42(2):301-310. [Abstract]
- Acta Pharmacol Sin. 2021 Jan;42(1):160-170. [Abstract]
- Phytomedicine. 2026 May:154:158057. [Abstract]
- Phytomedicine. 2026 Mar:152:157859. [Abstract]
- Phytomedicine. 2025 Oct 5:148:157378. [Abstract]
- Phytomedicine. 2025 Aug 16:147:157171. [Abstract]
- Phytomedicine. 2024 May:127:155463. [Abstract]
- Phytomedicine. 2024 Jan:122:155079. [Abstract]
- Phytomedicine. 2023 Mar:111:154668. [Abstract]
- Phytomedicine. 2021 May:85:153551. [Abstract]
- Free Radic Biol Med. 2026 May:248:150-161. [Abstract]
- Free Radic Biol Med. 2025 Aug 1:235:231-247. [Abstract]
- Free Radic Biol Med. 2025 Feb 16:228:173-182. [Abstract]
- Free Radic Biol Med. 2024 Aug 29:S0891-5849(24)00620-8. [Abstract]
- Free Radic Biol Med. 2024 Jun 28:S0891-5849(24)00542-2. [Abstract]
- Free Radic Biol Med. 2024 Jun 19:S0891-5849(24)00531-8. [Abstract]
- Free Radic Biol Med. 2024 Aug 1:220:56-66. [Abstract]
- Free Radic Biol Med. 2023 Jul:203:86-101. [Abstract]
- Free Radic Biol Med. 2022 Nov 20;193(Pt 1):202-212. [Abstract]
- Sci Total Environ. 2024 Jun 30:946:174246. [Abstract]
- Br J Pharmacol. 2021 Mar;178(5):1133-1148. [Abstract]
- Biomed Pharmacother. 2024 Jun:175:116734. [Abstract]
- Biomed Pharmacother. 2024 Mar:172:116301. [Abstract]
- Food Sci Hum Wellness. 2026 Mar 3.
- Oncogene. 2026 May;45(16):1411-1424. [Abstract]
- Environ Pollut. 2026 Feb 1:390:127547. [Abstract]
- Cell Death Discov. 2024 Aug 13;10(1):363. [Abstract]
- Cell Death Discov. 2024 Jan 23;10(1):42. [Abstract]
- Cell Death Discov. 2024 Jan 17;10(1):34. [Abstract]
- Cell Death Discov. 2023 Aug 25;9(1):311. [Abstract]
- Cell Rep. 2025 Sep 1;44(9):116139. [Abstract]
- Microbiol Res. 2024 Dec:289:127916. [Abstract]
- Cell Rep. 2024 Aug 22;43(9):114662. [Abstract]
- Microbiol Res. 2024 Apr 6:284:127711. [Abstract]
- Appl Mater Today. 2021, 101027.
- Cell Rep. 2020 Dec 8;33(10):108487. [Abstract]
- Clin Transl Med. 2022 Feb;12(2):e747. [Abstract]
- Antioxidants (Basel). 2023 Dec 19;13(1):3. [Abstract]
- Antioxidants (Basel). 2022 Dec 31;12(1):100. [Abstract]
- J Anim Sci Biotechnol. 2025 Feb 14;16(1):24. [Abstract]
- Int J Radiat Oncol Biol Phys. 2023 Nov 15;117(4):966-978. [Abstract]
- Fundam Res. 2025 Dec 16.
- J Agric Food Chem. 2025 Jul 9;73(27):17205-17218. [Abstract]
- J Agric Food Chem. 2024 Nov 6;72(44):24417-24431. [Abstract]
- Ind Crops Prod. 2024 Sep 1, 215, 118652.
- Antioxid Redox Signal. 2022 Apr;36(10-12):740-759. [Abstract]
- Hum Reprod. 2021 Mar 18;36(4):951-964. [Abstract]
- Cancer Cell Int. 2023 Aug 16;23(1):171. [Abstract]
- Cell Biol Toxicol. 2023 Dec;39(6):3015-3030. [Abstract]
- J Invest Dermatol. 2023 Feb;143(2):305-316.e5. [Abstract]
- Biomater Sci. 2019 Mar 26;7(4):1311-1322. [Abstract]
- Biochem Pharmacol. 2026 Jun:248:117848. [Abstract]
- Biochem Pharmacol. 2026 Mar:245:117683. [Abstract]
- Breast Cancer Res. 2025 Jul 6;27(1):124. [Abstract]
- Biochem Pharmacol. 2025 Jan 18:116763. [Abstract]
- Biochem Pharmacol. 2025 Jan 29:116788. [Abstract]
- Biochem Pharmacol. 2024 May:223:116194. [Abstract]
- Chem Biol Interact. 2026 Jun 1:432:112047. [Abstract]
- Chem Biol Interact. 2025 Jun 18:111614. [Abstract]
- Chem Biol Interact. 2025 May 1:412:111459. [Abstract]
- Chem Biol Interact. 2023 Aug 25:381:110555. [Abstract]
- Inflammopharmacology. 2025 Nov 21. [Abstract]
- Liver Int. 2020 Jun;40(6):1378-1394. [Abstract]
- Drug Des Devel Ther. 2022 Sep 7:16:2981-2993. [Abstract]
- CNS Neurosci Ther. 2026 Mar;32(3):e70830. [Abstract]
- Nutrients. 2025 Feb 25;17(5):794. [Abstract]
- Int J Mol Sci. 2025 Dec 1;26(23):11641. [Abstract]
- Int J Mol Sci. 2025 Nov 18;26(22):11146. [Abstract]
- Int J Mol Sci. 2025 Apr 10;26(8):3553. [Abstract]
- Int J Mol Sci. 2025 Apr 8;26(8):3482. [Abstract]
- Int J Mol Sci. 2025 Feb 22;26(5):1899. [Abstract]
- Int J Mol Sci. 2024 Mar 14;25(6):3315. [Abstract]
- Int J Mol Sci. 2024 Feb 20;25(5):2458. [Abstract]
- Int J Mol Sci. 2022 Sep 20;23(19):11004. [Abstract]
- Int J Mol Sci. 2022 Aug 12;23(16):9014. [Abstract]
- Int J Mol Sci. 2021 Aug 18;22(16):8898. [Abstract]
- Pharm Biol. 2026 Dec;64(1):514-535. [Abstract]
- Biomolecules. 2025 Dec 18;15(12):1749. [Abstract]
- Front Pharmacol. 2025 Jun 4:16:1567942. [Abstract]
- Pharmaceuticals (Basel). 2024 Jul 2;17(7):871. [Abstract]
- Front Cell Infect Microbiol. 2022 Feb 4;12:825824. [Abstract]
- Int Immunopharmacol. 2026 Jan 1;168(Pt 2):115892. [Abstract]
- Int Immunopharmacol. 2025 Apr 24:153:114455. [Abstract]
- Eur J Pharmacol. 2024 Dec 5:984:177061. [Abstract]
- Eur J Pharmacol. 2024 Jul 25:176859. [Abstract]
- Int Immunopharmacol. 2022 Apr 25;109:108770. [Abstract]
- Toxicology. 2026 Mar:521:154394. [Abstract]
- Molecules. 2025 Jul 24;30(15):3095. [Abstract]
- Molecules. 2025 Feb 24;30(5):1031. [Abstract]
- Cancer Sci. 2025 Jul 28. [Abstract]
- FASEB J. 2025 Dec 31;39(24):e71369. [Abstract]
- J Mol Med (Berl). 2025 Jul;103(7):849-866. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2024 Dec 30:167645. [Abstract]
- J Cell Mol Med. 2024 Nov;28(22):e70188. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2024 Jun;1870(5):167215. [Abstract]
- J Cell Mol Med. 2023 Dec;27(24):4118-4132. [Abstract]
- J Inflamm. 2019 May 29:16:11. [Abstract]
- J Neurochem. 2025 Oct;169(10):e70246. [Abstract]
- Front Cell Neurosci. 2021 Apr 6:15:632354. [Abstract]
- Sci Rep. 2026 Mar 6;16(1):12384. [Abstract]
- Fish Shellfish Immunol. 2026 Jun:173:111268. [Abstract]
- Sci Rep. 2026 Jan 16;16(1):5566. [Abstract]
- Sci Rep. 2025 Aug 18;15(1):30197. [Abstract]
- Sci Rep. 2025 Apr 18;15(1):13377. [Abstract]
- Fish Shellfish Immunol. 2023 Nov:142:109145. [Abstract]
- Aquaculture. 2024 Jan 30, 579, 740203.
- ACS Chem Neurosci. 2019 Dec 18;10(12):4824-4833. [Abstract]
- Oncol Rep. 2019 Aug;42(2):826-838. [Abstract]
- Clin Immunol. 2023 Nov:256:109778. [Abstract]
- Cell Signal. 2025 Nov:135:112010. [Abstract]
- Cell Signal. 2025 Jul:131:111683. [Abstract]
- Cell Signal. 2025 Jan 3:111583. [Abstract]
- Cell Signal. 2023 Sep:109:110791. [Abstract]
- ACS Pharmacol Transl Sci. 2022 Dec 7;6(1):100-114. [Abstract]
- Heliyon. 2024 Sep 24;10(20):e38151. [Abstract]
- Heliyon. 2024 Mar 21;10(7):e28364. [Abstract]
- Heliyon. 2022 Oct 12;8(10):e11013. [Abstract]
- Food Chem Toxicol. 2022 Aug:166:113255. [Abstract]
- Toxicol Appl Pharmacol. 2025 Aug 21:117531. [Abstract]
- Eur J Med Res. 2025 Jan 4;30(1):3. [Abstract]
- Cell Cycle. 2023 Apr;22(7):818-828. [Abstract]
- Eur J Pain. 2021 Jul;25(6):1227-1240. [Abstract]
- Mol Carcinog. 2026 May 15. [Abstract]
- Hum Mol Genet. 2024 May 22:ddae085. [Abstract]
- J Cancer. 2023 Jul 16;14(12):2236-2245. [Abstract]
- Mol Carcinog. 2023 Aug;62(8):1119-1135. [Abstract]
- Curr Issues Mol Biol. 2026 Jan 27;48(2):138. [Abstract]
- Discov Oncol. 2025 Jul 21;16(1):1383. [Abstract]
- Oral Dis. 2025 Jan;31(1):264-277. [Abstract]
- Carcinogenesis. 2023 Dec 2;44(8-9):708-715. [Abstract]
- J Cancer Res Clin Oncol. 2024 Sep 23;150(9):429. [Abstract]
- Exp Eye Res. 2026 Apr:265:110872. [Abstract]
- Surgery. 2024 Jun;175(6):1539-1546. [Abstract]
- Toxicol In Vitro. 2020 Feb;62:104715. [Abstract]
- Epigenomics. 2024;16(15-16):1097-1115. [Abstract]
- Adv Biol (Weinh). 2023 Jul;7(7):e2200336. [Abstract]
- Cell Biochem Biophys. 2025 Mar;83(1):1313-1320. [Abstract]
- Mol Cell Neurosci. 2026 Mar 17:104078. [Abstract]
- Gene. 2023 Aug 5:876:147515. [Abstract]
- FEBS Open Bio. 2022 Jun;12(6):1197-1205. [Abstract]
- Biochem Biophys Res Commun. 2026 Apr 16:809:153480. [Abstract]
- Biochem Biophys Res Commun. 2025 Dec 15:792:152981. [Abstract]
- Head Neck. 2025 Feb;47(2):504-516. [Abstract]
- Biochem Biophys Res Commun. 2024 May 28:710:149895. [Abstract]
- Biochem Biophys Res Commun. 2024 Jan 1:690:149274. [Abstract]
- Biochem Biophys Res Commun. 2019 Nov 5;519(2):240-245. [Abstract]
- Biochem Biophys Res Commun. 2019 Nov 12;519(3):533-539. [Abstract]
- Biochem Biophys Res Commun. 2018 Sep 3;503(1):297-303. [Abstract]
- Clinical and Translational Discovery. 20 February 2022.
- Biol Pharm Bull. 2020;43(3):480-487. [Abstract]
- bioRxiv. 2026 Apr 17:2026.04.15.718809. [Abstract]
- SSRN. 2026 Mar 20.
- bioRxiv. 2026 Mar 31.
- bioRxiv. 2026 Mar 16.
- Res Sq. 2026 Jan 15.
- SSRN. 2025 Nov 25.
- bioRxiv. 2025 Jun 6:2025.06.03.657677. [Abstract]
- University of Zurich. 2025 Feb 03.
- Research Square Preprint. 2024 Dec 02.
- bioRxiv. 2024 October 21.
- Res Sq. 2024 Jul 09.
- SSRN. 2024 Jun 18.
- biorxiv. 2024 May 27.
- Research Square Preprint. 2023 Nov 17.
- bioRxiv. 2023 Nov 5:2023.11.05.565697. [Abstract]
- Research Square Preprint. 2023 Aug 31.
- SSRN. 2023 Jun 19.
- Research Square Print. 2023 Feb 20.
- Oxid Med Cell Longev. 2022 Oct 15;2022:8063897. [Abstract]
- Oxid Med Cell Longev. 2022 Jul 5:2022:8983667. [Abstract]
- Research Square Preprint. 2022 Jun.
- Oxid Med Cell Longev. 2021 Feb 10:2021:6670497. [Abstract]
Customer Validation & Images
-
In Vivo Imaging
-
Cell Proliferation/Viability Assay
-
Cell Proliferation/Viability Assay
-
Cell Proliferation/Viability Assay
-
Cell Proliferation/Viability Assay
Biological Activity
Liproxstatin-1 shows antiferroptotic activity with an IC50 of approximately 38 nM in mouse embryonic fibroblasts[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2250025-95-5
-
Appearance Solid
-
Molecular Weight 377.31
-
Formula C19H22Cl2N4
-
Color Light yellow to brown
-
SMILES
ClC1=CC(CNC(C23CCNCC2)=NC4=C(N3)C=CC=C4)=CC=C1.[H]Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (235)
-
Journal Impact Factor
-
Most Recent
-
Signal Transduct Target Ther
Inhibin beta A drives colorectal cancer progression through macrophage M2 polarization and mitochondria-dependent ferroptosis suppression. [Abstract]2025 Dec 26;10(1):420. PMID: 41449244 -
Signal Transduct Target Ther
Disruption of heme homeostasis by nuclear receptor Nur77 induces pyroptosis through granzyme B-dependent GSDMC cleavage. [Abstract]2025 Dec 17;10(1):413. PMID: 41407678 -
Cell
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis. [Abstract]2025 Aug 21;188(17):4567-4585.e32. PMID: 40532699 -
Cell Stem Cell
Mitochondrial serine catabolism safeguards maintenance of the hematopoietic stem cell pool in homeostasis and injury. [Abstract]2024 Aug 21:S1934-5909(24)00285-6. PMID: 39181130 -
Bioact Mater
Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis. [Abstract]2021 Nov 19;13:23-36. PMID: 35224289 -
Nat Cell Biol
Peritumoural adipose tissue promotes ferroptosis resistance by 3-hydroxykynurenine-mediated suppression of ferritinophagy. [Abstract]2026 Apr;28(4):783-796. PMID: 41813885 -
Cancer Res
CLK2 Regulates the KEAP1/NRF2 and p53 Pathways to Suppress Ferroptosis in Colorectal Cancer. [Abstract]2025 Aug 29. PMID: 40882016 -
Mol Cell
2025 Aug 7;85(15):2973-2987.e6. PMID: 40712585 -
Cancer Res
ASS1-mediated reductive carboxylation of cytosolic glutamine confers ferroptosis resistance in cancer cells. [Abstract]2023 May 15;83(10):1646-1665. PMID: 36892426 -
Nat Commun
Ascites protects against ferroptosis and enables the peritoneal growth of ovarian cancer. [Abstract]2026 May 11;17(1):4190. PMID: 42115216 -
Nat Commun
2025 Dec 8. PMID: 41361241 -
Nat Commun
Co-delivery of sorafenib and an FSP1 inhibitor triggers dual ferroptosis in tumor cells and immunosuppressive macrophages for enhanced immunotherapy in mouse models of hepatocellular carcinoma. [Abstract]2025 Nov 18;16(1):10096. PMID: 41253833 -
Nat Commun
2023 Mar 17;14(1):1430. PMID: 36932056 -
Cell Death Differ
Inhibition of ferroptosis counteracts the advanced maternal age-induced oocyte deterioration. [Abstract]2025 Jun;32(6):1071-1085. PMID: 39910323 -
Cell Death Differ
Redox regulation of TRIM28 facilitates neuronal ferroptosis by promoting SUMOylation and inhibiting OPTN-selective autophagic degradation of ACSL4. [Abstract]2025 Jun;32(6):1041-1057. PMID: 39875520 -
Cell Death Differ
The AKR1C1-CYP1B1-cAMP signaling axis controls tumorigenicity and ferroptosis susceptibility of extrahepatic cholangiocarcinoma. [Abstract]2025 Mar;32(3):506-520. PMID: 39478199 -
Cell Death Differ
The IDH1-R132H mutation aggravates cisplatin-induced acute kidney injury by promoting ferroptosis through disrupting NDUFA1 and FSP1 interaction. [Abstract]2025 Feb;32(2):242-255. PMID: 39306640 -
Adv Sci (Weinh)
2025 Jan 31:e2408845. PMID: 39888307 -
Adv Sci (Weinh)
Enhanced Photodynamic Therapy Synergizing with Inhibition of Tumor Neutrophil Ferroptosis Boosts Anti-PD-1 Therapy of Gastric Cancer. [Abstract]2024 Mar;11(12):e2307870. PMID: 38233204 -
Adv Sci (Weinh)
PRMT3-Mediated Arginine Methylation of METTL14 Promotes Malignant Progression and Treatment Resistance in Endometrial Carcinoma. [Abstract]2023 Dec;10(36):e2303812. PMID: 37973560
Liproxstatin-1 hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2023 Dec;10(36):e2303812. [Abstract]
Cell viability of HEC-1A cells transfected with sh‐PRMT3 and treated with erastin in the absence or presence of liproxstatin‐1 (400 nM), ZVAD‐FMK (10 µM), 3‐methyladenine (1 mM) or necrosulfonamide (10 µM) for 48 h.
-
Adv Sci (Weinh)
Inhibition of CDK1 Overcomes Oxaliplatin Resistance by Regulating ACSL4-mediated Ferroptosis in Colorectal Cancer. [Abstract]2023 Sep;10(25):e2301088. PMID: 37428466 -
Adv Sci (Weinh)
ANO1-Mediated Inhibition of Cancer Ferroptosis Confers Immunotherapeutic Resistance through Recruiting Cancer-Associated Fibroblasts. [Abstract]2023 Aug;10(24):e2300881. PMID: 37341301 -
J Clin Invest
4-1BB stimulation with concomitant inactivation of adenosine A2B receptors enhances CD8+ T cell antitumor response. [Abstract]2025 Apr 3:e190841. PMID: 40178905 -
J Clin Invest
ZMYND8 protects breast cancer stem cells against oxidative stress and ferroptosis through activation of NRF2. [Abstract]2024 Jan 23;134(6):e171166. PMID: 38488001 -
Theranostics
PRMT6-mediated ADMA promotes p62 phase separation to form a negative feedback loop in ferroptosis. [Abstract]2024 Jul 2;14(10):4090-4106. PMID: 38994016
Liproxstatin-1 hydrochloride purchased from MedChemExpress. Usage Cited in: Theranostics. 2024 Jul 2;14(10):4090-4106. [Abstract]
Liproxstatin 1 (Lip-1) (48 h) largely reverses the cytotoxicity of ferroptosis inducers enhanced by p62 knockdown in Hela cells.
-
Theranostics
Deficiency of the X-inactivation escaping gene KDM5C in clear cell renal cell carcinoma promotes tumorigenicity by reprogramming glycogen metabolism and inhibiting ferroptosis. [Abstract]2021 Aug 4;11(18):8674-8691. PMID: 34522206 -
-
J Adv Res
Restoring cardiolipin homeostasis mitigates cerebral ischemia-reperfusion injury by suppressing ATG5-mediated neuronal autophagy-dependent ferroptosis. [Abstract]2026 Mar 12:S2090-1232(26)00234-1. PMID: 41831680 -
Exp Mol Med
RNA-binding protein HnRNPU regulates proliferation and ferroptosis in colon adenocarcinoma by stabilizing the mRNA of system xc. [Abstract]2025 Nov;57(11):2686-2698. PMID: 41310105 -
Biomaterials
2024 Jan:304:122430. PMID: 38100907
Liproxstatin-1 hydrochloride purchased from MedChemExpress. Usage Cited in: Biomaterials. 2024 Jan:304:122430. [Abstract]
Liproxstatin-1 (1 μM). The concentration-dependent cytotoxicity of LysoCOS7, LysoRaw and LysoNeu in the presence of various inhibitors.
-
J Nanobiotechnology
Fe-doped phase-transition nanodroplets for synergistic photothermal and starvation-enhanced ferroptosis in cancer therapy. [Abstract]2025 Oct 16;23(1):684. PMID: 41102809 -
Small
A Ferrocene-Functionalized Covalent Organic Framework for Enhancing Chemodynamic Therapy via Redox Dyshomeostasis. [Abstract]2021 Aug;17(32):e2101368. PMID: 34216420 -
Redox Biol
Apolipoprotein C3 exacerbates vascular calcification by promoting ferroptosis via the TLR2/AMPK pathway in vascular smooth muscle cells. [Abstract]2026 Apr:91:104088. PMID: 41734579 -
Redox Biol
Methylation reader MBD2-mediated GPX4 transcriptional repression drives ovarian granulosa cell ferroptosis in PCOS. [Abstract]2026 Mar:90:104034. PMID: 41576700 -
Redox Biol
p53 and fatty acids collaborate to trigger ferroptosis via the FBXO2-FABP5 axis in colorectal cancer. [Abstract]2026 Mar:90:104043. PMID: 41604941 -
Redox Biol
Ferroptosis in acute liver Failure: Unraveling the hepcidin-ferroportin axis and therapeutic interventions. [Abstract]2025 May 8:84:103657. PMID: 40393152 -
Redox Biol
Niraparib restricts intraperitoneal metastases of ovarian cancer by eliciting CD36-dependent ferroptosis. [Abstract]2025 Feb 3:80:103528. PMID: 39922130
Liproxstatin-1 hydrochloride purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Feb 3:80:103528. [Abstract]
Tp53-deficient ID8 tumor-bearing mice were administered with Niraparib (50 mg/kg) from day 6, and administered with Lipro-1 (10 mg/kg, intraperitoneally, a single dose) and SSO (sulfosuccinimidyl oleate) (50 mg/kg, intragastrically, a single dose) from day 3. Representative actual or bioluminescent images of mice after a 3-week treatment.
-
Redox Biol
Reactivation of MAPK-SOX2 pathway confers ferroptosis sensitivity in KRASG12C inhibitor resistant tumors. [Abstract]2024 Nov 5:78:103419. PMID: 39527862
Liproxstatin-1 hydrochloride purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Nov 5:78:103419. [Abstract]
Cell viability of the control NCI–H358, Calu-1, NCI–H23, MIA PaCa-2 and the corresponding resistant cell lines after 24 h of treatment with the indicated compounds. 2 μM liproxstatin-1 (Lip-1), 10 μM sorafenib or 10 μM lapatinib was used to treat NCI–H358, NCI–H23 and MIA PaCa-2 cells, while Calu-1 cells were treated with 2 μM liproxstatin-1 (Lip-1), 3 μM sorafenib or 10 μM lapatinib (n = 3).
-
Redox Biol
Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment. [Abstract]2024 Dec 5:79:103460. PMID: 39657365
Liproxstatin-1 hydrochloride purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Dec 5:79:103460. [Abstract]
143B and SJSA-1 cells were treated with SFN with or without Lip-1 (1 μM) for 48 h, and cell viability was evaluated.
-
Redox Biol
2024 Sep:75:103270. PMID: 39047638 -
Redox Biol
Redistribution of defective mitochondria-mediated dihydroorotate dehydrogenase imparts 5-fluorouracil resistance in colorectal cancer. [Abstract]2024 May 23:73:103207. PMID: 38805974
Liproxstatin-1 hydrochloride purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 May 23:73:103207. [Abstract]
Cell survival of 5FU-R cells treated with a gradient concentration of PUFAs and 10 μM ferrostatin-1, or 10 μM liproxstatin-1 for 24 h.
-
Redox Biol
2019 Jun:24:101211. PMID: 31108460 -
J Hazard Mater
Low-dose deoxynivalenol exposure triggers hepatic excessive ferritinophagy and mitophagy mitigated by hesperidin modulated O-GlcNAcylation. [Abstract]2024 Dec 5:480:135952. PMID: 39341193
Liproxstatin-1 hydrochloride purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2024 Dec 5:480:135952. [Abstract]
Liproxstatin-1 (100 nM; 50 h) alleviates the decrease in O-GlcNAcylation levels and ferroptosis-related proteins in AML12 cells caused by DON (48 h) exposure.
-
Research (Wash D C)
DNA Methylation-Mediated GPX4 Transcriptional Repression and Osteoblast Ferroptosis Promote Titanium Particle-Induced Osteolysis. [Abstract]2024 Aug 19:7:0457. PMID: 39161535 -
MedComm
2024 Apr 4;5(4):e520. PMID: 38576455
Liproxstatin-1 hydrochloride purchased from MedChemExpress. Usage Cited in: MedComm. 2024 Apr 4;5(4):e520. [Abstract]
Antiferroptosis treatment repressed the development of AS in vivo. Normal group: normal diet; HFD group: HFD for 3 months; HFD + ferrostatin‐1 group: HFD accompanied by ferrostatin‐1 treatment (1 mg/kg, twice a day, i.p.); HFD + liproxstatin‐1 group: HFD accompanied by liproxstatin‐1 treatment (10 mg/kg, twice a day, i.p.). IHC of 4‐HEN (ferroptosis marker) in aortic sinus.
-
Cell Mol Biol Lett
2025 Oct 2;30(1):109. PMID: 41039223 -
Int J Biol Sci
METTL16 suppresses ferroptosis in cholangiocarcinoma by promoting ATF4 via m6A modification. [Abstract]2025 Jan 1;21(1):189-203. PMID: 39744432 -
Food Chem
Fish oil nano-emulsion kills macrophage: Ferroptosis triggered by catalase-catalysed superoxide eruption. [Abstract]2023 May 15:408:135249. PMID: 36566546 -
J Colloid Interface Sci
Photoactive metal-covalent organic framework nanozymes with enhanced peroxidase-mimicking activity for eliminating drug-resistant bacterial infections. [Abstract]2025 Jun 12;699(Pt 1):138178. PMID: 40527142 -
J Colloid Interface Sci
Orchestrating apoptosis and ferroptosis through enhanced sonodynamic therapy using amorphous UIO-66-CoOx. [Abstract]2024 Aug:667:91-100. PMID: 38621335 -
J Colloid Interface Sci
Interfacial strong interaction-enabling cascade nanozymes for apoptosis-ferroptosis synergistic therapy. [Abstract]2024 Jan;653(Pt A):20-29. PMID: 37708728 -
Cell Death Dis
BRD4 inhibition suppresses histone H4 UFMylation to increase ferroptosis sensitivity through TXNIP. [Abstract]2025 Nov 17;16(1):843. PMID: 41249136 -
Cell Death Dis
Intratumoral Brevibacillus parabrevis enhances antitumor immunity by inhibiting NK cell ferroptosis in hepatocellular carcinoma. [Abstract]2025 May 21;16(1):407. PMID: 40399270 -
Cell Death Dis
Intracellular C5aR1 inhibits ferroptosis in glioblastoma through METTL3-dependent m6A methylation of GPX4. [Abstract]2024 Oct 5;15(10):729. PMID: 39368999 -
Cell Death Dis
PDIA4 confers resistance to ferroptosis via induction of ATF4/SLC7A11 in renal cell carcinoma. [Abstract]2023 Mar 11;14(3):193. PMID: 36906674 -
Cell Death Dis
Inhibition of autophagy and MEK promotes ferroptosis in Lkb1-deficient Kras-driven lung tumors. [Abstract]2023 Jan 26;14(1):61. PMID: 36702816 -
Cell Death Dis
2022 Sep 26;13(9):825. PMID: 36163182 -
Cell Death Dis
The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages. [Abstract]2022 Jul 28;13(7):653. PMID: 35902564 -
Cell Death Dis
Oncogenic circTICRR suppresses autophagy via binding to HuR protein and stabilizing GLUD1 mRNA in cervical cancer. [Abstract]2022 May 20;13(5):479. PMID: 35595754 -
Cell Death Dis
Liproxstatin-1 attenuates unilateral ureteral obstruction-induced renal fibrosis by inhibiting renal tubular epithelial cells ferroptosis. [Abstract]2021 Sep 11;12(9):843. PMID: 34511597 -
Cell Death Dis
"Iron free" zinc oxide nanoparticles with ion-leaking properties disrupt intracellular ROS and iron homeostasis to induce ferroptosis. [Abstract]2020 Mar 13;11(3):183. PMID: 32170066 -
Sci China Life Sci
Melanin precursors mediated adaption to temperature changes in fungus and animal via inhibition of lipid-mediated ferroptosis. [Abstract]2023 Aug;66(8):1800-1817. PMID: 36949229 -
Acta Pharmacol Sin
Baicalein triggers ferroptosis in colorectal cancer cells via blocking the JAK2/STAT3/GPX4 axis. [Abstract]2024 Aug;45(8):1715-1726. PMID: 38684798 -
Acta Pharmacol Sin
2021 Feb;42(2):301-310. PMID: 32699265 -
Acta Pharmacol Sin
2021 Jan;42(1):160-170. PMID: 32541921 -
Phytomedicine
Liquiritigenin targets transferrin receptor to potentiate ferroptosis sensitivity in colorectal cancer cells. [Abstract]2026 May:154:158057. PMID: 41833103 -
Phytomedicine
Arnicolide C induces ferroptosis in liver cancer through modulation of the HMOX1-TRC8 axis. [Abstract]2026 Mar:152:157859. PMID: 41579588 -
Phytomedicine
Cistanche deserticola extract and its active components, echinacoside, ameliorate sarcopenia by activating the IGF-1/PI3K-AKT pathway to modulate ferroptosis. [Abstract]2025 Oct 5:148:157378. PMID: 41106096 -
Phytomedicine
Cinobufagin overcomes bortezomib resistance in multiple myeloma strains by targeting SEC62/TRPM4-mediated NECSO. [Abstract]2025 Aug 16:147:157171. PMID: 40839992 -
Phytomedicine
Penthorum chinense Pursh inhibits ferroptosis in cellular and Caenorhabditis elegans models of Alzheimer's disease. [Abstract]2024 May:127:155463. PMID: 38452694 -
Phytomedicine
Timosaponin AIII induces lipid peroxidation and ferroptosis by enhancing Rab7-mediated lipophagy in colorectal cancer cells. [Abstract]2024 Jan:122:155079. PMID: 37863004 -
Phytomedicine
Tiliroside targets TBK1 to induce ferroptosis and sensitize hepatocellular carcinoma to sorafenib. [Abstract]2023 Mar:111:154668. PMID: 36657316 -
Phytomedicine
Shuganning injection, a traditional Chinese patent medicine, induces ferroptosis and suppresses tumor growth in triple-negative breast cancer cells. [Abstract]2021 May:85:153551. PMID: 33827043 -
Free Radic Biol Med
Radiotherapy disrupts ferroptosis tolerance by reducing DNMT1 levels and uncouples STING silencing in LKB1-deficient lung tumors. [Abstract]2026 May:248:150-161. PMID: 41722660 -
Free Radic Biol Med
Resveratrol induces ferroptosis in triple-negative breast cancer through NEDD4L-mediated GPX4 ubiquitination and degradation. [Abstract]2025 Aug 1:235:231-247. PMID: 40316059 -
Free Radic Biol Med
Ferroptosis and PANoptosis under hypoxia pivoting on the crosstalk between DHODH and GPX4 in corneal epithelium. [Abstract]2025 Feb 16:228:173-182. PMID: 39761766 -
Free Radic Biol Med
Targeting ALDH2 to augment platinum-based chemosensitivity through ferroptosis in lung adenocarcinoma. [Abstract]2024 Aug 29:S0891-5849(24)00620-8. PMID: 39216560 -
Free Radic Biol Med
A Streptococcus pneumoniae endolysin mutant protein ΔA146Ply elicits rapid broad-spectrum mucosal protection in mice via upregulation of GPX4 through TLR4/IRG1/NRF2 to alleviate macrophage ferroptosis. [Abstract]2024 Jun 28:S0891-5849(24)00542-2. PMID: 38945457 -
Free Radic Biol Med
Mifepristone protects acetaminophen induced liver injury through NRF2/GSH/GST mediated ferroptosis suppression. [Abstract]2024 Jun 19:S0891-5849(24)00531-8. PMID: 38906233 -
Free Radic Biol Med
Microglial gp91phox-mediated neuroinflammation and ferroptosis contributes to learning and memory deficits in rotenone-treated mice. [Abstract]2024 Aug 1:220:56-66. PMID: 38697489 -
Free Radic Biol Med
Targeting ABCB6 with nitidine chloride inhibits PI3K/AKT signaling pathway to promote ferroptosis in multiple myeloma. [Abstract]2023 Jul:203:86-101. PMID: 37044150 -
Free Radic Biol Med
Manganese induces tumor cell ferroptosis through type-I IFN dependent inhibition of mitochondrial dihydroorotate dehydrogenase. [Abstract]2022 Nov 20;193(Pt 1):202-212. PMID: 36228830 -
Sci Total Environ
Voltage-dependent anion channel 1 mediates mitochondrial fission and glucose metabolic reprogramming in response to ionizing radiation. [Abstract]2024 Jun 30:946:174246. PMID: 38955266 -
Br J Pharmacol
Quercetin induces p53-independent cancer cell death through lysosome activation by the transcription factor EB and Reactive Oxygen Species-dependent ferroptosis. [Abstract]2021 Mar;178(5):1133-1148. PMID: 33347603 -
Biomed Pharmacother
Alpha-tocopherol inhibits ferroptosis and promotes neural function recovery in rats with spinal cord injury via downregulating Alox15. [Abstract]2024 Jun:175:116734. PMID: 38754264 -
Biomed Pharmacother
Soluble epoxide hydrolase inhibitor (TPPU) alleviates ferroptosis by regulating CCL5 after intracerebral hemorrhage in mice. [Abstract]2024 Mar:172:116301. PMID: 38377737 -
-
Oncogene
CAPRIN1-mediated sequestration of NCOA4 mRNA into stress granules drives sorafenib resistance in hepatocellular carcinoma. [Abstract]2026 May;45(16):1411-1424. PMID: 41896589 -
Environ Pollut
Arsenic exposure reduces testosterone synthesis partially by evoking Leydig cell ferroptosis in mouse testes. [Abstract]2026 Feb 1:390:127547. PMID: 41412458 -
Cell Death Discov
MDH2 regulates the sensitivity of clear cell renal cell carcinoma to ferroptosis through its interaction with FSP1. [Abstract]2024 Aug 13;10(1):363. PMID: 39138167 -
Cell Death Discov
Exogenous carbon monoxide promotes GPX4-dependent ferroptosis through ROS/GSK3β axis in non-small cell lung cancer. [Abstract]2024 Jan 23;10(1):42. PMID: 38263152 -
Cell Death Discov
2024 Jan 17;10(1):34. PMID: 38233385
Liproxstatin-1 hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2024 Jan 17;10(1):34. [Abstract]
After pretreatment with Fer-1 (10 μM), Lip-1 (2 μM), or DFO (10 μM) for 1 hour, the cells were treated with GLU or NMDA (1 mM) for 24 hours, and then flow cytometry was performed.
-
Cell Death Discov
Ferroptosis contributes to ethanol-induced hepatic cell death via labile iron accumulation and GPx4 inactivation. [Abstract]2023 Aug 25;9(1):311. PMID: 37626043 -
Cell Rep
SLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer. [Abstract]2025 Sep 1;44(9):116139. PMID: 40892544 -
Microbiol Res
Inhibition of calpain reduces oxidative stress and attenuates pyroptosis and ferroptosis in Clostridium perfringens Beta-1 toxin-induced macrophages. [Abstract]2024 Dec:289:127916. PMID: 39342748 -
Cell Rep
CRISPR screening identifies PRMT1 as a key pro-ferroptotic gene via a two-layer regulatory mechanism. [Abstract]2024 Aug 22;43(9):114662. PMID: 39178116 -
Microbiol Res
Ferrous gluconate triggers ferroptosis in Escherichia coli: Implications of lipid peroxidation and DNA damage. [Abstract]2024 Apr 6:284:127711. PMID: 38636240 -
-
Cell Rep
HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications. [Abstract]2020 Dec 8;33(10):108487. PMID: 33296645 -
Clin Transl Med
Tumour cells are sensitised to ferroptosis via RB1CC1-mediated transcriptional reprogramming. [Abstract]2022 Feb;12(2):e747. PMID: 35220675 -
Antioxidants (Basel)
PTC596-Induced BMI-1 Inhibition Fights Neuroblastoma Multidrug Resistance by Inducing Ferroptosis. [Abstract]2023 Dec 19;13(1):3. PMID: 38275623 -
Antioxidants (Basel)
Identification of AP-1 as a Critical Regulator of Glutathione Peroxidase 4 (GPX4) Transcriptional Suppression and Acinar Cell Ferroptosis in Acute Pancreatitis. [Abstract]2022 Dec 31;12(1):100. PMID: 36670963 -
J Anim Sci Biotechnol
Bovine milk-derived extracellular vesicles reduce oxidative stress and ferroptosis induced by Klebsiella pneumoniae in bovine mammary epithelial cells. [Abstract]2025 Feb 14;16(1):24. PMID: 39953606 -
Int J Radiat Oncol Biol Phys
Acetyl-CoA Acetyltransferase 2 Confers Radioresistance by Inhibiting Ferroptosis in Esophageal Squamous Cell Carcinoma. [Abstract]2023 Nov 15;117(4):966-978. PMID: 37244629 -
-
J Agric Food Chem
Ginsenoside RK1 Promotes Hepatic Stellate Cell Glycolysis-Mediated Ferroptosis by Activating the HK2/ACSL4/LPCAT3/ALOX5 Signaling Pathway. [Abstract]2025 Jul 9;73(27):17205-17218. PMID: 40570179 -
J Agric Food Chem
Nuciferine Alleviates High-Fat Diet- and ApoE-/--Induced Hepatic Steatosis and Ferroptosis in NAFLD Mice via the PPARα Signaling Pathway. [Abstract]2024 Nov 6;72(44):24417-24431. PMID: 39445611 -
-
Antioxid Redox Signal
A Novel Identified Circular RNA, mmu_mmu_circRNA_0000309, Involves in Germacrone-Mediated Improvement of Diabetic Nephropathy Through Regulating Ferroptosis by Targeting miR-188-3p/GPX4 Signaling Axis. [Abstract]2022 Apr;36(10-12):740-759. PMID: 34913724 -
Hum Reprod
2021 Mar 18;36(4):951-964. PMID: 33378529 -
Cancer Cell Int
A novel quinoline derivative, DFIQ, sensitizes NSCLC cells to ferroptosis by promoting oxidative stress accompanied by autophagic dysfunction and mitochondrial damage. [Abstract]2023 Aug 16;23(1):171. PMID: 37587444 -
Cell Biol Toxicol
GPR116 promotes ferroptosis in sepsis-induced liver injury by suppressing system Xc-/GSH/GPX4. [Abstract]2023 Dec;39(6):3015-3030. PMID: 37266730 -
J Invest Dermatol
The regulators of peroxisomal acyl-carnitine shuttle CROT and CRAT promote metastasis in melanoma. [Abstract]2023 Feb;143(2):305-316.e5. PMID: 36058299 -
Biomater Sci
Assessment of zero-valent iron-based nanotherapeutics for ferroptosis induction and resensitization strategy in cancer cells. [Abstract]2019 Mar 26;7(4):1311-1322. PMID: 30734774 -
Biochem Pharmacol
Celastrol induces liver cancer cell death via TFEB-mediated lysosome activation and ROS-dependent ferroptosis. [Abstract]2026 Jun:248:117848. PMID: 41759594 -
Biochem Pharmacol
Imperatorin induces ferroptosis via mediating lipid peroxidation and SLC7A11/ACSL4/GPX4 signaling for inhibition and therapeutics of prostate cancer. [Abstract]2026 Mar:245:117683. PMID: 41506540 -
Breast Cancer Res
THEM6 modulates carboplatin sensitivity by regulating ferroptosis through FDFT1 in triple-negative breast cancer. [Abstract]2025 Jul 6;27(1):124. PMID: 40619388 -
Biochem Pharmacol
Cotargeting of thioredoxin 1 and glutamate-cysteine ligase in both imatinib-sensitive and imatinib-resistant CML cells. [Abstract]2025 Jan 18:116763. PMID: 39832669 -
Biochem Pharmacol
Inhibition of ferroptosis protects intrahepatic bile duct cells against ischemia-reperfusion and bile salt toxicity. [Abstract]2025 Jan 29:116788. PMID: 39890033 -
Biochem Pharmacol
Jolkinolide B synergistically potentiates the antitumor activity of GPX4 inhibitors via inhibiting TrxR1 in cisplatin-resistant bladder cancer cells. [Abstract]2024 May:223:116194. PMID: 38583812 -
Chem Biol Interact
Cyclophosphamide-induced iron homeostasis imbalance triggers ovarian toxicity through ferroptosis of ovarian granulosa cells in a mitophagy crosstalk manner. [Abstract]2026 Jun 1:432:112047. PMID: 41861985 -
Chem Biol Interact
Metallothioneins protect against isoconazole nitrate-induced antitumor activity through the maintenance of cellular redox homeostasis in hepatocellular carcinoma. [Abstract]2025 Jun 18:111614. PMID: 40541645 -
Chem Biol Interact
The anti-Alzheimer's disease effects of ganoderic acid A by inhibiting ferroptosis-lipid peroxidation via activation of the NRF2/SLC7A11/GPX4 signaling pathway. [Abstract]2025 May 1:412:111459. PMID: 40054827 -
Chem Biol Interact
Fluoride resistance capacity in mammalian cells involves global gene expression changes associate with ferroptosis. [Abstract]2023 Aug 25:381:110555. PMID: 37245782 -
Inflammopharmacology
Metformin alleviates presbycusis by activating the SIRT1/PINK1/GPX4 pathway in vitro and in vivo. [Abstract]2025 Nov 21. PMID: 41269477 -
Liver Int
Targeting ferroptosis alleviates methionine-choline deficient (MCD)-diet induced NASH by suppressing liver lipotoxicity. [Abstract]2020 Jun;40(6):1378-1394. PMID: 32145145 -
Drug Des Devel Ther
Levistilide a Induces Ferroptosis by Activating the Nrf2/HO-1 Signaling Pathway in Breast Cancer Cells. [Abstract]2022 Sep 7:16:2981-2993. PMID: 36105321 -
CNS Neurosci Ther
Ferroptosis-Driven Neuronal Damage Exacerbation in Diabetic Stroke: Implications of SLC7A11 Inhibition. [Abstract]2026 Mar;32(3):e70830. PMID: 41820788 -
Nutrients
Medium-Chain Fatty Acids Selectively Sensitize Cancer Cells to Ferroptosis by Inducing CD36 and ACSL4. [Abstract]2025 Feb 25;17(5):794. PMID: 40077664 -
Int J Mol Sci
Liproxstatin-1 Protects SH-SY5Y Cells by Inhibiting H2O2-Induced Excessive Mitophagy and Apoptosis. [Abstract]2025 Dec 1;26(23):11641. PMID: 41373790 -
Int J Mol Sci
Resveratrol-Supported Bioenergetics Leads to Higher Productivity and Accompanying Endoplasmic Reticulum Stress in a mAb-Producing CHO Cell Line. [Abstract]2025 Nov 18;26(22):11146. PMID: 41303629 -
Int J Mol Sci
Inhibition of ACSL4 Attenuates Behavioral Deficits by Regulating Ferroptosis in a Murine Model of Systemic Lupus Erythematosus. [Abstract]2025 Apr 10;26(8):3553. PMID: 40332005 -
Int J Mol Sci
CD36 Induces Inflammation by Promoting Ferroptosis in Pancreas, Epididymal Adipose Tissue, and Adipose Tissue Macrophages in Obesity-Related Severe Acute Pancreatitis. [Abstract]2025 Apr 8;26(8):3482. PMID: 40331957 -
Int J Mol Sci
MGST1 Protects Pancreatic Ductal Cells from Inflammatory Damage in Acute Pancreatitis by Inhibiting Ferroptosis: Bioinformatics Analysis with Experimental Validation. [Abstract]2025 Feb 22;26(5):1899. PMID: 40076525 -
Int J Mol Sci
TRIM21 Promotes Oxidative Stress and Ferroptosis through the SQSTM1-NRF2-KEAP1 Axis to Increase the Titers of H5N1 Highly Pathogenic Avian Influenza Virus. [Abstract]2024 Mar 14;25(6):3315. PMID: 38542289 -
Int J Mol Sci
2024 Feb 20;25(5):2458. PMID: 38473706 -
Int J Mol Sci
The Possible Connection of Two Dual Function Processes: The Relationship of Ferroptosis and the JNK Pathway. [Abstract]2022 Sep 20;23(19):11004. PMID: 36232313 -
Int J Mol Sci
Combination RSL3 Treatment Sensitizes Ferroptosis- and EGFR-Inhibition-Resistant HNSCCs to Cetuximab. [Abstract]2022 Aug 12;23(16):9014. PMID: 36012290 -
Int J Mol Sci
A Shortage of FTH Induces ROS and Sensitizes RAS-Proficient Neuroblastoma N2A Cells to Ferroptosis. [Abstract]2021 Aug 18;22(16):8898. PMID: 34445601 -
Pharm Biol
Ginkgolic acid targets HSPA8 to trigger ferroptosis in hepatocellular carcinoma via chaperone-mediated autophagy-dependent GPX4 degradation. [Abstract]2026 Dec;64(1):514-535. PMID: 41877645 -
Biomolecules
RSL3 Promotes STAT3 Ubiquitination to Induce Autophagy and Apoptosis in PARPi-Resistant Breast Cancer Cells. [Abstract]2025 Dec 18;15(12):1749. PMID: 41463402 -
Front Pharmacol
2025 Jun 4:16:1567942. PMID: 40535769 -
Pharmaceuticals (Basel)
Ginsenoside RK1 Induces Ferroptosis in Hepatocellular Carcinoma Cells through an FSP1-Dependent Pathway. [Abstract]2024 Jul 2;17(7):871. PMID: 39065721 -
Front Cell Infect Microbiol
Dysregulation of Cytosolic c-di-GMP in Edwardsiella piscicida Promotes Cellular Non-Canonical Ferroptosis. [Abstract]2022 Feb 4;12:825824. PMID: 35186798 -
Int Immunopharmacol
2026 Jan 1;168(Pt 2):115892. PMID: 41273847 -
Int Immunopharmacol
Oxidized low-density lipoprotein induced ferroptosis in nucleus pulposus cell contributes to intervertebral disc degeneration via LOX-1/NF-κB/NOX signal. [Abstract]2025 Apr 24:153:114455. PMID: 40112598 -
Eur J Pharmacol
Longikaurin A induces ferroptosis and inhibits glioblastoma progression through DNA methylation - Mediated GPX4 suppression. [Abstract]2024 Dec 5:984:177061. PMID: 39426467 -
Eur J Pharmacol
Exploring the potential mechanism of ginsenoside Rg1 to regulate ferroptosis in Alzheimer's disease based on network pharmacology. [Abstract]2024 Jul 25:176859. PMID: 39067563 -
Int Immunopharmacol
Liproxstatin-1 alleviates LPS/IL-13-induced bronchial epithelial cell injury and neutrophilic asthma in mice by inhibiting ferroptosis. [Abstract]2022 Apr 25;109:108770. PMID: 35483233 -
Toxicology
NOX4/Keap1/Nrf2/ROS signaling drives ferroptosis in trimethyltin chloride-induced cardiac developmental malformations. [Abstract]2026 Mar:521:154394. PMID: 41485541 -
Molecules
2025 Jul 24;30(15):3095. PMID: 40807270 -
Molecules
Research for a Common Thread: Insights into the Mechanisms of Six Potential Anticancer Agents. [Abstract]2025 Feb 24;30(5):1031. PMID: 40076255 -
Cancer Sci
TP-0903 Suppresses Aurora A-PLK1 Signaling to Inhibit Proliferation of a Myelodysplastic Syndrome-Derived Cell Line. [Abstract]2025 Jul 28. PMID: 40722126 -
FASEB J
RSL3 Mitigates Doxorubicin Resistance in Breast Cancer via Targeted Disruption of Glycolytic Flux. [Abstract]2025 Dec 31;39(24):e71369. PMID: 41408993 -
J Mol Med (Berl)
Cerium oxide nanoparticles as potent inhibitors of ferroptosis: role of antioxidant activity and protein regulation. [Abstract]2025 Jul;103(7):849-866. PMID: 40448735 -
Biochim Biophys Acta Mol Basis Dis
PDIA4 targets IRE1α/sXBP1 to alleviate NLRP3 inflammasome activation and renal tubular injury in diabetic kidney disease. [Abstract]2024 Dec 30:167645. PMID: 39743023 -
J Cell Mol Med
Repurposing flubendazole for glioblastoma ferroptosis by affecting xCT and TFRC proteins. [Abstract]2024 Nov;28(22):e70188. PMID: 39543084 -
Biochim Biophys Acta Mol Basis Dis
Botulinum toxin A attenuates osteoarthritis development via inhibiting chondrocyte ferroptosis through SLC7Al1/GPX4 axis. [Abstract]2024 Jun;1870(5):167215. PMID: 38714267 -
J Cell Mol Med
KIAA1429 protects hepatocellular carcinoma cells from ferroptotic cell death with a m6 A-dependent posttranscriptional modification of SLC7A11. [Abstract]2023 Dec;27(24):4118-4132. PMID: 37830241 -
J Inflamm
Ferroptosis inhibitor alleviates Radiation-induced lung fibrosis (RILF) via down-regulation of TGF-β1. [Abstract]2019 May 29:16:11. PMID: 31160885 -
J Neurochem
Neuronal Damage Induced by Gradual Oxidative Stress in iPSC-Derived Neurons: Implications for Ferroptosis Involvement and ALS Drug Evaluation. [Abstract]2025 Oct;169(10):e70246. PMID: 41017138 -
Front Cell Neurosci
Inhibition of Acyl-CoA Synthetase Long-Chain Family Member 4 Facilitates Neurological Recovery After Stroke by Regulation Ferroptosis. [Abstract]2021 Apr 6:15:632354. PMID: 33889074 -
Sci Rep
Quercetin-4'-O-β-D-glucopyranoside inhibits ferroptosis though SIRT5-mediated desuccinylation of TFR1 in diabetic nephropathy. [Abstract]2026 Mar 6;16(1):12384. PMID: 41792305 -
Fish Shellfish Immunol
The AhR/ROS-mediated lipid peroxidation pathway contributes to 6PPDQ-induced intestine-specific injury in zebrafish during embryonic development. [Abstract]2026 Jun:173:111268. PMID: 41819393 -
Sci Rep
Fine particulate matter exacerbates childhood asthma via DNMT3A-mediated modulation of GPX4 DNA methylation. [Abstract]2026 Jan 16;16(1):5566. PMID: 41545575 -
Sci Rep
Sulfasalazine induces ferroptosis in osteosarcomas by regulating Nrf2/SLC7A11/GPX4 signaling axis. [Abstract]2025 Aug 18;15(1):30197. PMID: 40825957 -
Sci Rep
Caerin 1.1 and 1.9 peptides induce acute caspase 3/GSDME-mediated pyroptosis in epithelial cancer cells. [Abstract]2025 Apr 18;15(1):13377. PMID: 40251208 -
Fish Shellfish Immunol
Vitamin D ameliorates Aeromonas hydrophila-induced iron-dependent oxidative damage of grass carp splenic macrophages by manipulating Nrf2-mediated antioxidant pathway. [Abstract]2023 Nov:142:109145. PMID: 37805110 -
-
ACS Chem Neurosci
Liproxstatin-1 Attenuates Morphine Tolerance through Inhibiting Spinal Ferroptosis-like Cell Death. [Abstract]2019 Dec 18;10(12):4824-4833. PMID: 31682397 -
Oncol Rep
Sulfasalazine‑induced ferroptosis in breast cancer cells is reduced by the inhibitory effect of estrogen receptor on the transferrin receptor. [Abstract]2019 Aug;42(2):826-838. PMID: 31173262 -
Clin Immunol
2023 Nov:256:109778. PMID: 37730009 -
Cell Signal
Histone methyltransferase G9a drives ferroptosis to aggravate vascular calcification by inhibiting SLC7A11 transcription. [Abstract]2025 Nov:135:112010. PMID: 40684965 -
Cell Signal
Mitochondrial ferritin inhibition aggravates pacing-induced ventricular arrhythmias after myocardial infarction by promoting cardiomyocyte ferroptosis. [Abstract]2025 Jul:131:111683. PMID: 40023300 -
Cell Signal
HDAC inhibitor enhances ferroptosis susceptibility of AML cells by stimulating iron metabolism. [Abstract]2025 Jan 3:111583. PMID: 39756501 -
Cell Signal
Curcumin derivative NL01 induces ferroptosis in ovarian cancer cells via HCAR1/MCT1 signaling. [Abstract]2023 Sep:109:110791. PMID: 37406786 -
ACS Pharmacol Transl Sci
Inhibition of Protein Disulfide Isomerase (PDIA1) Leads to Proteasome-Mediated Degradation of Ubiquitin-like PHD and RING Finger Domain-Containing Protein 1 (UHRF1) and Increased Sensitivity of Glioblastoma Cells to Topoisomerase II Inhibitors. [Abstract]2022 Dec 7;6(1):100-114. PMID: 36654750 -
Heliyon
2024 Sep 24;10(20):e38151. PMID: 39498038 -
Heliyon
Plumbagin induces ferroptosis in colon cancer cells by regulating p53-related SLC7A11 expression. [Abstract]2024 Mar 21;10(7):e28364. PMID: 38596137 -
Heliyon
3-Deoxysappanchalcone isolated from Caesalpinia sinensis shows anticancer effects on HeLa and PC3 cell lines: invasion, migration, cell cycle arrest, and signaling pathway. [Abstract]2022 Oct 12;8(10):e11013. PMID: 36276736 -
Food Chem Toxicol
Patulin disrupts SLC7A11-cystine-cysteine-GSH antioxidant system and promotes renal cell ferroptosis both in vitro and in vivo. [Abstract]2022 Aug:166:113255. PMID: 35772596 -
Toxicol Appl Pharmacol
Chrysin enhances sunitinib sensitivity in renal cell carcinoma by inducing ferroptosis via targeting PI3K/Akt/GPX4 pathway. [Abstract]2025 Aug 21:117531. PMID: 40848919 -
Eur J Med Res
RNA-binding protein DAZAP1 accelerates the advancement of pancreatic cancer by inhibiting ferroptosis. [Abstract]2025 Jan 4;30(1):3. PMID: 39754243 -
Cell Cycle
Dimethyl fumarate protects against hepatic ischemia-reperfusion injury by alleviating ferroptosis via the NRF2/SLC7A11/HO-1 axis. [Abstract]2023 Apr;22(7):818-828. PMID: 36482709 -
Eur J Pain
Inhibition of ferroptosis-like cell death attenuates neuropathic pain reactions induced by peripheral nerve injury in rats. [Abstract]2021 Jul;25(6):1227-1240. PMID: 33497529 -
Mol Carcinog
LKB1 Loss Sensitizes Lung Tumor Spheres to Mitomet-Induced Ferroptosis, and These Effects are Enhanced by mTOR Inhibition. [Abstract]2026 May 15. PMID: 42138621 -
Hum Mol Genet
2024 May 22:ddae085. PMID: 38776958 -
J Cancer
QiLing Decoction promotes ferroptosis of castration-resistant prostate cancer cells by inhibiting FSP1 in vitro and in vivo. [Abstract]2023 Jul 16;14(12):2236-2245. PMID: 37576395 -
Mol Carcinog
PRMT1 inhibition promotes ferroptosis sensitivity via ACSL1 upregulation in acute myeloid leukemia. [Abstract]2023 Aug;62(8):1119-1135. PMID: 37144835 -
Curr Issues Mol Biol
Cucurbitacin B Inhibits Hepatocellular Carcinoma by Inducing Ferroptosis and Activating the cGAS-STING Pathway. [Abstract]2026 Jan 27;48(2):138. PMID: 41751402 -
Discov Oncol
The role of RAB GTPases in predicting prognosis and therapy response in pancreatic cancer. [Abstract]2025 Jul 21;16(1):1383. PMID: 40690079 -
Oral Dis
Indoxyl sulfate exacerbates alveolar bone loss in chronic kidney disease through ferroptosis. [Abstract]2025 Jan;31(1):264-277. PMID: 38934473 -
Carcinogenesis
SOCS1 acts as a ferroptosis driver to inhibit the progression and chemotherapy resistance of triple-negative breast cancer. [Abstract]2023 Dec 2;44(8-9):708-715. PMID: 37665951 -
J Cancer Res Clin Oncol
2024 Sep 23;150(9):429. PMID: 39311951 -
Exp Eye Res
Resveratrol alleviated diabetic retinal neuronal ferroptosis induced by high glucose through inhibiting HIF-1α and HMOX1 pathway. [Abstract]2026 Apr:265:110872. PMID: 41554423 -
Surgery
Exacerbated ischemia-reperfusion injury in fatty livers is mediated by lipid peroxidation stress and ferroptosis. [Abstract]2024 Jun;175(6):1539-1546. PMID: 38508920 -
Toxicol In Vitro
Gastrodin protects against glutamate-induced ferroptosis in HT-22 cells through Nrf2/HO-1 signaling pathway. [Abstract]2020 Feb;62:104715. PMID: 31698019 -
Epigenomics
LINC01232 promotes ARNTL2 transcriptional activation and inhibits ferroptosis of CRC cells through p300/H3K27ac. [Abstract]2024;16(15-16):1097-1115. PMID: 39268727 -
Adv Biol (Weinh)
2023 Jul;7(7):e2200336. PMID: 37132155 -
Cell Biochem Biophys
T-Box Transcription Factor 2 Mediates Chemoresistance of Endometrial Cancer via Regulating FSP1-involved Ferroptosis. [Abstract]2025 Mar;83(1):1313-1320. PMID: 39325362 -
Mol Cell Neurosci
Liproxstatin-1 improves functional recovery after acute spinal cord injury by inhibiting ferroptosis-induced inflammation. [Abstract]2026 Mar 17:104078. PMID: 41856443 -
Gene
Inhibit ALDH3A2 reduce ovarian cancer cells survival via elevating ferroptosis sensitivity. [Abstract]2023 Aug 5:876:147515. PMID: 37247796 -
FEBS Open Bio
2022 Jun;12(6):1197-1205. PMID: 35258176 -
Biochem Biophys Res Commun
Protection by maslinic acid against cisplatin-induced ototoxicity: rescue of ferroptosis by targeting the SLC7A11-GSH-GPX4 pathway. [Abstract]2026 Apr 16:809:153480. PMID: 41722247 -
Biochem Biophys Res Commun
2025 Dec 15:792:152981. PMID: 41242297 -
Head Neck
2025 Feb;47(2):504-516. PMID: 39290130 -
Biochem Biophys Res Commun
Non-cytotoxic nanomolar concentration of arctigenin protects neuronal cells from chemotherapy-induced ferroptosis by regulating SLC7A11-cystine-cysteine axis. [Abstract]2024 May 28:710:149895. PMID: 38593620 -
Biochem Biophys Res Commun
2024 Jan 1:690:149274. PMID: 37995455 -
Biochem Biophys Res Commun
2019 Nov 5;519(2):240-245. PMID: 31493867
Liproxstatin-1 hydrochloride purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2019 Nov 5;519(2):240-245. [Abstract]
The ROS and inflammatory cytokines levels increase in acute RILI. The serum levels of inflammatory cytokines increase in RILI. Elisa was used to measure the levels of inflammatory cytokines (TNF-a, IL-6, IL-10 and TGF-b1) at day 15, day 30 and day 60.
-
Biochem Biophys Res Commun
Artesunate activates the ATF4-CHOP-CHAC1 pathway and affects ferroptosis in Burkitt's Lymphoma. [Abstract]2019 Nov 12;519(3):533-539. PMID: 31537387 -
Biochem Biophys Res Commun
Effects of intracellular iron overload on cell death and identification of potent cell death inhibitors. [Abstract]2018 Sep 3;503(1):297-303. PMID: 29890135 -
-
Biol Pharm Bull
Gastrodin Inhibits H2O2-Induced Ferroptosis through Its Antioxidative Effect in Rat Glioma Cell Line C6. [Abstract]2020;43(3):480-487. PMID: 32115506 -
bioRxiv
β-Amyloid and Glutathione Dysregulation Cooperatively Drive Lipid Peroxidation and Ferroptosis in Neuron-Like Cells. [Abstract]2026 Apr 17:2026.04.15.718809. PMID: 42039567 -
-
-
-
-
-
bioRxiv
2025 Jun 6:2025.06.03.657677. PMID: 40501672 -
-
-
-
-
-
-
-
bioRxiv
Targeting LINC00152 activates cAMP/Ca2+/ferroptosis axis and overcomes tamoxifen resistance in ER+ breast cancer. [Abstract]2023 Nov 5:2023.11.05.565697. PMID: 38496603 -
-
-
-
Oxid Med Cell Longev
Attenuation by Time-Restricted Feeding of High-Fat and High-Fructose Diet-Induced NASH in Mice Is Related to Per2 and Ferroptosis. [Abstract]2022 Oct 15;2022:8063897. PMID: 36285301 -
Oxid Med Cell Longev
Bone Marrow Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying circ_0050205 Attenuate Intervertebral Disc Degeneration. [Abstract]2022 Jul 5:2022:8983667. PMID: 35847582 -
-
Oxid Med Cell Longev
Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration In Vivo. [Abstract]2021 Feb 10:2021:6670497. PMID: 33628376
Solvent & Solubility
DMSO : 5.83 mg/mL (15.45 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
-
Data Sheet (274 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
[1]. Friedmann Angeli JP, et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol. 2014 Dec;16(12):1180-91. [Content Brief]
[2]. Zilka O, et al. On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death. ACS Cent Sci. 2017 Mar 22;3(3):232-243 [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6503 mL | 13.2517 mL | 26.5034 mL | 66.2585 mL |
| 5 mM | 0.5301 mL | 2.6503 mL | 5.3007 mL | 13.2517 mL | |
| 10 mM | 0.2650 mL | 1.3252 mL | 2.6503 mL | 6.6259 mL | |
| 15 mM | 0.1767 mL | 0.8834 mL | 1.7669 mL | 4.4172 mL |
Powered by Bioz