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CDH15 - cadherin 15 Gene

Also Known as CDH3; CDHM; MCAD; MRD3; CDH14

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1013

About CDH15

Cytogenetic location: 16q24.3 Genomic coordinates (GRCh38): 16:89,171,748-89,195,492 (from NCBI)

This gene has 3 transcripts (splice variants), 193 orthologues, 33 paralogues and is associated with 3 phenotypes. Low expression observed in reference dataset.

Summary

This gene is a member of the Cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 Cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular Cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation. [provided by RefSeq, Jul 2008]

CDH15 Products (1)

mRNA	Protein	Name
NM_004933.3	NP_004924.1	cadherin-15 preproprotein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDH15 Protein Structure

Cadherin

Cadherin_C

0
200
400
600
814 a.a.

Protein Preferred Names	Protein Names
cadherin-15	cadherin 15, type 1, M-cadherin (myotubule)

CDH15 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CDH15	P55291	SGTA	Homo sapiens	O43765	Y2H Array	32296183
Intra	CDH15	P55291	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
Intra	CDH15	P55291	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183
Intra	CDH15	P55291	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183
Intra	CDH15	P55291	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	CDH15	P55291	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	CDH15	P55291	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	CDH15	P55291	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder, Autosomal Dominant 3	MRD3 Autosomal Dominant Non-Syndromic Intellectual Disability 3 Mental Retardation, Autosomal Dominant 3 Autosomal Dominant Intellectual Developmental Disorder 3
Autosomal Dominant Non-Syndromic Intellectual Disability
Hypotrichosis, Congenital, With Juvenile Macular Dystrophy	HJMD Congenital Hypotrichosis With Juvenile Macular Dystrophy Hypotrichosis With Cone-Rod Dystrophy Hypotrichosis With Juvenile Macular Dystrophy Juvenile Macular Degeneration And Hypotrichosis Juvenile Macular Dystrophy And Congenital Hypotrichosis Hypotrichosis With Juvenile Macular Degeneration Hypotrichosis Congenital With Juvenile Macular Dystrophy
Ectodermal Dysplasia, Ectrodactyly, And Macular Dystrophy Syndrome	Eem Syndrome Ectodermal Dysplasia, Ectrodactyly, And Macular Dystrophy EEMS Ectodermal Dysplasia-Ectrodactyly-Macular Dystrophy Syndrome Albrectsen-Svendsen Syndrome Ohdo-Hirayama-Terawaki Syndrome Dysplasia, Ectodermal, Ectrodactyly, And Macular Dystrophy
Intellectual Developmental Disorder, Autosomal Dominant 4	MRD4 Autosomal Dominant Non-Syndromic Intellectual Disability 4 Mental Retardation, Autosomal Dominant 4 Autosomal Dominant Intellectual Developmental Disorder 4
Hypotrichosis 2	HYPT2 Hypotrichosis Simplex Of The Scalp 1 Htss1 Htss Hypotrichosis, Spanish Type Spanish Type Hypotrichosis Hypotrichosis Spanish Type Hypotrichosis, Type 2 Hypotrichosis Simplex Of Scalp
T-Cell Immunodeficiency, Congenital Alopecia, And Nail Dystrophy	Winged Helix Deficiency Alymphoid Cystic Thymic Dysgenesis Severe T-Cell Immunodeficiency-Congenital Alopecia-Nail Dystrophy Syndrome Pignata Guarino Syndrome TIDAND T-Cell Immunodeficiency, Congenital Alopecia And Nail Dystrophy Congenital Alopecia And Nail Dystrophy Associated With Severe Functional T-Cell Immunodeficiency Severe Combined Immunodeficiency Due To Foxn1 Deficiency Foxn1 Deficiency Nude/Scid Nude/Severe Combined Immunodeficiency Scid Due To Foxn1 Deficiency Severe T-Cell Immunodeficiency-Congenital Alopecia-Nail Dystrophy
Craniofacial-Deafness-Hand Syndrome	CDHS Craniofacial Deafness Hand Syndrome Sommer-Young-Wee-Frye Syndrome Features Of Flat Facial Profile, Hypertelorism, Hypoplastic Nose With Slitlike Nares, And A Sensorineural Hearing Loss Craniofacial-Hearing Loss-Hand Syndrome
Hypotrichosis 11	HYPT11 Hypotrichosis, Type 11
Kbg Syndrome	KBGS Macrodontia, Mental Retardation, Characteristic Facies, Short Stature, And Skeletal Anomalies Short Stature, Characteristic Facies, Macrodontia, Intellectual Disability, And Skeletal Anomalies Short Stature, Characteristic Facies, Macrodontia, Mental Retardation, And Skeletal Anomalies Short Stature-Characteristic Facies-Mental Retardation-Macrodontia-Skeletal Anomalies Syndrome Short Stature-Facial And Skeletal Anomalies-Intellectual Disability-Macrodontia Syndrome
Hypotrichosis 8	HYPT8 Lah3 Hypotrichosis, Localized, Autosomal Recessive 3 Woolly Hair, Autosomal Recessive 1, With Or Without Hypotrichosis Autosomal Recessive Woolly Hair 1, With Or Without Hypotrichosis Hypotrichosis Localized Autosomal Recessive 3 Woolly Hair Autosomal Recessive 1 With Or Without Hypotrichosis ARWH1 Hypotrichosis, Type 8
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02325	CDH15 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19178	Cdh15 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25667	Cdh15 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CDH15	VGNC	VGNC:70808
Felis catus	CDH15	VGNC	VGNC:60673
Canis familiaris	CDH15	VGNC	VGNC:39023
Rattus norvegicus	CDH15	RGD	RGD:1303000
Mus musculus	CDH15	MGD	MGI:106672
Bos taurus	CDH15	VGNC	VGNC:27094
Others	CDH15	NCBI