GUCY1B1 - guanylate cyclase 1 soluble subunit beta 1 Gene

Also Known as GUCB3; GC-SB3; GUC1B3; GUCSB3; GUCY1B3; GC-S-beta-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2983

About GUCY1B1

Cytogenetic location: 4q32.1 Genomic coordinates (GRCh38): 4:155,759,021-155,807,811 (from NCBI)

This gene has 8 transcripts (splice variants), 211 orthologues and 17 paralogues. Broad expression in brain (RPKM 21.9), placenta (RPKM 13.8) and 21 other tissues.

Summary

This gene encodes the beta subunit of the soluble Guanylate Cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

GUCY1B1 Products (6)

mRNA	Protein	Name
NM_000857.5	NP_000848.1	guanylate cyclase soluble subunit beta-1 isoform 2
NM_001291951.3	NP_001278880.1	guanylate cyclase soluble subunit beta-1 isoform 1
NM_001291952.3	NP_001278881.1	guanylate cyclase soluble subunit beta-1 isoform 3
NM_001291953.3	NP_001278882.1	guanylate cyclase soluble subunit beta-1 isoform 4
NM_001291954.3	NP_001278883.1	guanylate cyclase soluble subunit beta-1 isoform 5
NM_001291955.3	NP_001278884.1	guanylate cyclase soluble subunit beta-1 isoform 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables guanylate cyclase activity	IDA IDA: Inferred from direct assay	23505436	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23505436	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cGMP biosynthetic process	IDA IDA: Inferred from direct assay	23505436	GOA
involved in nitric oxide-cGMP-mediated signaling	IDA IDA: Inferred from direct assay	23505436	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of guanylate cyclase complex, soluble	IDA IDA: Inferred from direct assay	23505436	GOA
part of guanylate cyclase complex, soluble	IPI IPI: Inferred from physical interaction	23505436	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GUCY1B1 Protein Structure

HNOB

HNOBA

Guanylate_cyc

0
100
200
300
400
500
619 a.a.

Protein Preferred Names	Protein Names
guanylate cyclase soluble subunit beta-1	GCS-beta-1

GUCY1B1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GUCY1B1	Q02153	GUCY1A1	Homo sapiens	Q02108	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

GUCY1B1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82402	Guanylyl Cyclase beta 1 Antibody (YA2147)	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Nemaline Myopathy 7	NEM7 Nemaline Myopathy 7, Autosomal Recessive Cfl2-Related Nemaline Myopathy Myopathy, Nemaline, Type 7
Bartter Syndrome, Type 2, Antenatal	Bartter Disease Type 2 BARTS2 Hyperprostaglandin E Syndrome 2 Bartter Syndrome, Type 2 Bartter Syndrome Type 2 Hypokalemic Alkalosis With Hypercalciuria Antenatal 2 Hypokalemic Alkalosis With Hypercalciuria 2, Antenatal Bartter Syndrome Type 2 Antenatal Hypokalemic Alkalosis With Hypercalciuria 2 Antenatal Bartter Syndrome Antenatal Type 2 Bartter Syndrome Type Ii Bartter Syndrome 2, Antenatal Abs2 Antenatal Bartter Syndrome 2 Bartter Syndrome 2 Bs2 Hyperprostanglandin E Syndrome 2 Bartter Syndrome, Antenatal , Type 2 Antley-Bixler Syndrome, Autosomal Dominant
Moyamoya Disease 1	Moyamoya Disease Spontaneous Occlusion Of The Circle Of Willis Mymy Progressive Intracranial Arterial Occlusion Moyamoya Syndrome MYMY1 Cerebrovascular Moyamoya Disease Moya-Moya Disease Progressive Intracranial Occlusive Arteropathy Idiopathic Moyamoya Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05920	GUCY1B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GUCY1B1	VGNC	VGNC:29721
Macaca mulatta	GUCY1B1	VGNC	VGNC:73328
Rattus norvegicus	GUCY1B1	RGD	RGD:2769
Mus musculus	GUCY1B1	MGD	MGI:1860604
Canis familiaris	GUCY1B1	VGNC	VGNC:41568
Felis catus	GUCY1B1	VGNC	VGNC:67515
Others	GUCY1B1	NCBI