GUCY1A1 - guanylate cyclase 1 soluble subunit alpha 1 Gene

Also Known as GUCA3; MYMY6; GC-SA3; GUC1A3; GUCSA3; GUCY1A3; GCS-alpha-3; GC-S-alpha-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2982

About GUCY1A1

Cytogenetic location: 4q32.1 Genomic coordinates (GRCh38): 4:155,666,848-155,737,059 (from NCBI)

This gene has 13 transcripts (splice variants), 203 orthologues, 17 paralogues and is associated with 2 phenotypes. Ubiquitous expression in prostate (RPKM 11.3), heart (RPKM 8.5) and 24 other tissues.

Summary

Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the Guanylate Cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GUCY1A1 Products (18)

mRNA Protein Name
NM_000856.6 NP_000847.2 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001130682.3 NP_001124154.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001130683.4 NP_001124155.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001130684.3 NP_001124156.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001130685.3 NP_001124157.1 guanylate cyclase soluble subunit alpha-1 isoform B
NM_001130687.3 NP_001124159.1 guanylate cyclase soluble subunit alpha-1 isoform D
NM_001256449.2 NP_001243378.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001379666.1 NP_001366595.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001379667.1 NP_001366596.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001379668.1 NP_001366597.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001379669.1 NP_001366598.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001379670.1 NP_001366599.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001379671.1 NP_001366600.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001379672.1 NP_001366601.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001379673.1 NP_001366602.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001379674.1 NP_001366603.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001379675.1 NP_001366604.1 guanylate cyclase soluble subunit alpha-1 isoform E
NM_001379676.1 NP_001366605.1 guanylate cyclase soluble subunit alpha-1 isoform F

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables guanylate cyclase activity IDA
IDA: Inferred from direct assay
23505436 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23505436 GOA
Biological Process GO Annotation Evidence References Source
involved in cGMP biosynthetic process IDA
IDA: Inferred from direct assay
23505436 GOA
involved in nitric oxide-cGMP-mediated signaling IDA
IDA: Inferred from direct assay
23505436 GOA
Cellular Component GO Annotation Evidence References Source
part of guanylate cyclase complex, soluble IDA
IDA: Inferred from direct assay
23505436 GOA
part of guanylate cyclase complex, soluble IPI
IPI: Inferred from physical interaction
23505436 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GUCY1A1 Protein Structure

HNOB

HNOB: Haem-NO-binding (90 - 234)

HNOBA

HNOBA: Heme NO binding associated (273 - 466)

Guanylate_cyc

Guanylate_cyc: Adenylate and Guanylate cyclase catalytic domain (472 - 643)

  • 0
  • 200
  • 400
  • 600
  • 690 a.a.
Protein Preferred Names Protein Names

guanylate cyclase soluble subunit alpha-1

  • guanylate cyclase 1, soluble, alpha 3

GUCY1A1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GUCY1A1 Q02108 GUCY1B1 Homo sapiens Q02153
X-Ray Diffraction
23505436
Intra
GUCY1A1 Q02108 GUCY1B1 Homo sapiens Q02153
GTPase Assay
23505436
Cross: Cross-species interaction Intra: Intraspecies interaction

GUCY1A1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83192 Guanylyl Cyclase alpha 1 Antibody (YA2937) WB Human
HY-P84467 GUCY1A3 Antibody (YA4164) WB, IHC-P, ICC/IF, FC, ELISA Human
HY-P84467A GUCY1A3 Antibody (YA4164)(PBS only) WB, IHC-P, ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Moyamoya Disease 6 With Or Without Achalasia

  • Moyamoya Disease With Early-Onset Achalasia

  • MYMY6

  • Moyamoya 6 With Achalasia

  • Moyamoya, With Achalasia, Type 6
Moyamoya Disease 1

  • Moyamoya Disease

  • Spontaneous Occlusion Of The Circle Of Willis

  • Mymy

  • Progressive Intracranial Arterial Occlusion

  • Moyamoya Syndrome

  • MYMY1

  • Cerebrovascular Moyamoya Disease

  • Moya-Moya Disease

  • Progressive Intracranial Occlusive Arteropathy

  • Idiopathic Moyamoya Disease
Myocardial Infarction

  • Heart Attack

  • Myocardial Infarction, Susceptibility To

  • Myocardial Infarction 1

  • Myocardial Infarction, Protection Against

  • Myocardial Infarction, Decreased Susceptibility To

  • Myocardial Infarction, Decreased

  • Myocardial Infarct

  • MCI1

  • Premature Myocardial Infarction

  • Myocardial Infarction, Susceptibility To, Type 1
Achalasia

  • Cardiospasm

  • Achalasia Of Cardia

  • Esophageal Achalasia

  • Hypertensive Lower Esophageal Sphincter

  • Idiopathic Achalasia

  • Achalasia Cardia

  • Idiopathic Achalasia Of Esophagus

  • Primary Achalasia

  • Achalasia Of Esophagus

  • Lack Of Reflex Relaxation Of Lower Oesophageal Sphincter

  • Aperistalsis Of The Oesophagus

  • Achalasia Of Oesophagus

  • Oesophageal Achalasia

  • Achalasia Nos

  • Cardia Spasm

  • Cardia Achalasia

  • Oesophageal Cardiospasm

  • Oesophagus Achalasia

  • Reflex Cardiospasm
Bartter Syndrome, Type 2, Antenatal

  • Bartter Disease Type 2

  • BARTS2

  • Hyperprostaglandin E Syndrome 2

  • Bartter Syndrome, Type 2

  • Bartter Syndrome Type 2

  • Hypokalemic Alkalosis With Hypercalciuria Antenatal 2

  • Hypokalemic Alkalosis With Hypercalciuria 2, Antenatal

  • Bartter Syndrome Type 2 Antenatal

  • Hypokalemic Alkalosis With Hypercalciuria 2 Antenatal

  • Bartter Syndrome Antenatal Type 2

  • Bartter Syndrome Type Ii

  • Bartter Syndrome 2, Antenatal

  • Abs2

  • Antenatal Bartter Syndrome 2

  • Bartter Syndrome 2

  • Bs2

  • Hyperprostanglandin E Syndrome 2

  • Bartter Syndrome, Antenatal , Type 2

  • Antley-Bixler Syndrome, Autosomal Dominant
Hemiplegia

  • Infantile Hemiplegia

  • Postnatal Infantile Hemiplegia

  • Hemiplegia, Infantile
Cerebral Arterial Disease

  • Cerebral Arterial Diseases
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05918 GUCY1A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05920 GUCY1B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GUCY1A1 VGNC VGNC:67514
Rattus norvegicus GUCY1A1 RGD RGD:68436
Macaca mulatta GUCY1A1 VGNC VGNC:73327
Mus musculus GUCY1A1 MGD MGI:1926562
Bos taurus GUCY1A1 VGNC VGNC:29720
Canis familiaris GUCY1A1 VGNC VGNC:41567
Others GUCY1A1 NCBI