Art. -Nr.: HY-W096600

2F-Peracetyl-Fucose

Name: 2F-Peracetyl-Fucose
Brand: MedChemExpress
SKU: HY-W096600
Price: 150.00 USD
Availability: InStock
Rating: 5 (4 reviews)

(Synonyms: 1,3,4-Tri-O-acetyl-2-deoxy-2-fluoro-L-fucopyranos)

4 Cited Publications

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Based on 4 publication(s) in Google Scholar

2F-Peracetyl-Fucose (1,3,4-Tri-O-acetyl-2-deoxy-2-fluoro-L-fucopyranos) acts as a potent fucosyltransferase (FUT) inhibitor.

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Reinheit : 99.54%
CAS. Nr.: 188783-78-0
Formel: C₁₂H₁₇FO₇
Molecular Weight:292.26

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

2F-Peracetyl-Fucose Chemical Structure

CAS. Nr.: 188783-78-0

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Publications (4)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

2F-Peracetyl-Fucose (1,3,4-Tri-O-acetyl-2-deoxy-2-fluoro-L-fucopyranos) acts as a potent fucosyltransferase (FUT) inhibitor^[1].

In Vitro

2F-Peracetyl-Fucose (64 μM, 72 hours) inhibits orosphere formation and invasion in UMSCC14B and UMSCC103 cells^[2].
2F-PAF (25-200 μM, 48 hours) inhibits migration ability in NCI-H3122 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Cell Invasion Assay^[2]

View Protocol

Cell Line:

UMSCC14B, UMSCC103 (head and neck squamous cell carcinoma)
Concentration:

64 μM
Incubation Time:

72 hours
Result:

Treated spheres were smaller with reduced invasion.

Cell Migration Assay ^[3]

View Protocol

Cell Line:

NCI-H3122 (NSCLC)
Concentration:

25-200 μM
Incubation Time:

48 hours
Result:

Reduced number of migrated cells.

In Vivo

2F-PAF (20 μg/ml, i.v., single dose) inhibits tumor metastasis in Calu-1 xenograft nude mouse model^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Calu-1 xenograft BALB/c nude mouse model^[3]
Dosage:

20 μg/ml
Administration:

Intravenous injection (i.v.), single dose
Result:

Reduced tumor colonization ability in the lungs.

Chemical Information

CAS. Nr. 188783-78-0
Appearance Solid
Molecular Weight 292.26
Formel C₁₂H₁₇FO₇
Color White to off-white
SMILES

C[C@H]1[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](F)C(OC(C)=O)O1
Synonyms

1,3,4-Tri-O-acetyl-2-deoxy-2-fluoro-L-fucopyranos
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (4)

All RT-PCRCell Imaging/StainingCell Migration/Invasion AssayIFCell Proliferation/Viability AssayWB

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Journal Impact Factor

Adv Sci (Weinh)

Synthetic Retinoid Sulfarotene Selectively Inhibits Tumor-Repopulating Cells of Intrahepatic Cholangiocarcinoma via Disrupting Cytoskeleton by P-Selectin/PSGL1 N-Glycosylation Blockage. [Abstract]

2025 Jan;12(3):e2407519. PMID: 39605300

2F-Peracetyl-Fucose purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jan;12(3):e2407519. [Abstract]

Inhibition of 2F-Peracetyl-Fucose (2‐FF) (10-50 μM) on colony spheroid growth in HUCCT1‐TRCs and RBE‐TRCs. The representative images of colony spheroids on day 8 (treatment from day3). 2‐FF treatment significantly inhibited the growth of colony spheroids.

2F-Peracetyl-Fucose purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jan;12(3):e2407519. [Abstract]

Effects of 2F-Peracetyl-Fucose (2‐FF) (10-50 μM) on the migration and invasion of HUCCT1‐TRCs and RBE‐TRCs. 2-FF treatment significantly inhibited migration and invasion in ICC-TRCs.

2F-Peracetyl-Fucose purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jan;12(3):e2407519. [Abstract]

Phalloidin staining showed the inhibition of 2F-Peracetyl-Fucose (2‐FF) (50 μM) on F‐actin of HUCCT1‐TRCs and RBE‐TRCs. Red, phalloidin; blue, DAPI. Scale, 20 µm.

2F-Peracetyl-Fucose purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jan;12(3):e2407519. [Abstract]

G‐actin/F‐actin in vivo assay kit and IB was used to investigate the alteration of F‐/G‐actin induced by 2F-Peracetyl-Fucose (2‐FF) (50 μM) treatment (n = 3, t‐test). 2‐FF treatment significantly inhibited F/G‐actin ratio in ICC‐TRCs.
JCI Insight

Age-related dysregulation of intestinal epithelium fucosylation is linked to an increased risk of colon cancer. [Abstract]

2024 Mar 8;9(5):e167676. PMID: 38456503

2F-Peracetyl-Fucose purchased from MedChemExpress. Usage Cited in: JCI Insight. 2024 Mar 8;9(5):e167676. [Abstract]

2F-Peracetyl-Fucose (2-FF) (300 μM; 24 h) markedly downregulated the expression levels of FUT2 and FUT8 in DLD-1 cells, indicating that 2-FF effectively suppressed epithelial fucosylation.

2F-Peracetyl-Fucose purchased from MedChemExpress. Usage Cited in: JCI Insight. 2024 Mar 8;9(5):e167676. [Abstract]

Typical images (left) and corresponding statistical results (right) of Transwell invasion and migration assays in DLD-1 cells treated with vehicle, RSV, and 2F-Peracetyl-Fucose (2FF). 2F-Peracetyl-Fucose (2FF, 300 μM, 24 h) inhibited the migration of DLD-1 cells. Scale bar = 50 μm.

2F-Peracetyl-Fucose purchased from MedChemExpress. Usage Cited in: JCI Insight. 2024 Mar 8;9(5):e167676. [Abstract]

Representative images (left) and quantification (right) of wound healing assay at 0 and 24 hours in DLD-1 cells treated with vehicle, RSV, and 2F-Peracetyl-Fucose (2FF). 2F-Peracetyl-Fucose (2FF, 300 μM, 24 h) inhibited the migration of DLD-1 cells. Light blue line marks scratch wound edges. Scale bar = 200 μm. Scratched areas were quantified as a percentage after 24 hours relative to 0 hours.

2F-Peracetyl-Fucose purchased from MedChemExpress. Usage Cited in: JCI Insight. 2024 Mar 8;9(5):e167676. [Abstract]

Measurement of cell proliferation using CCK8 assays. 2F-Peracetyl-Fucose (2FF, 300 μM, 24 h) inhibited the cell proliferation of DLD-1 cells.
PLoS Pathog

FUT8-mediated core fucosylation of receptor APN drives entry of multiple alphacoronaviruses. [Abstract]

2026 May 18;22(5):e1014227. PMID: 42149951
Research Square Preprint

2024 May 2.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (342.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 5 mg/mL (17.11 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.4216 mL

17.1081 mL

34.2161 mL

5 mM

0.6843 mL

3.4216 mL

6.8432 mL

10 mM

0.3422 mL

1.7108 mL

3.4216 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (8.55 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (8.55 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (8.55 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Martina Zimmermann, et al. Impact of Acetylated and Non-Acetylated Fucose Analogues on IgG Glycosylation. Antibodies (Basel). 2019 Jan 10;8(1):9. [Content Brief]

[2]. Desiderio V, et al. Increased fucosylation has a pivotal role in invasive and metastatic properties of head and neck cancer stem cells. Oncotarget. 2015 Jan 1;6(1):71-84. [Content Brief]

[3]. Park S, et al. Altered expression of fucosylation pathway genes is associated with poor prognosis and tumor metastasis in non‑small cell lung cancer. Int J Oncol. 2020 Feb;56(2):559-567. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	3.4216 mL	17.1081 mL	34.2161 mL	85.5403 mL
	5 mM	0.6843 mL	3.4216 mL	6.8432 mL	17.1081 mL
	10 mM	0.3422 mL	1.7108 mL	3.4216 mL	8.5540 mL
	15 mM	0.2281 mL	1.1405 mL	2.2811 mL	5.7027 mL
DMSO	20 mM	0.1711 mL	0.8554 mL	1.7108 mL	4.2770 mL
	25 mM	0.1369 mL	0.6843 mL	1.3686 mL	3.4216 mL
	30 mM	0.1141 mL	0.5703 mL	1.1405 mL	2.8513 mL
	40 mM	0.0855 mL	0.4277 mL	0.8554 mL	2.1385 mL
	50 mM	0.0684 mL	0.3422 mL	0.6843 mL	1.7108 mL
	60 mM	0.0570 mL	0.2851 mL	0.5703 mL	1.4257 mL
	80 mM	0.0428 mL	0.2139 mL	0.4277 mL	1.0693 mL
	100 mM	0.0342 mL	0.1711 mL	0.3422 mL	0.8554 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Bioz

Keywords

2F-Peracetyl-Fucose

4 Cited Publications

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2F-Peracetyl-Fucose

Publications Citing Use of MedChemExpress (MCE) 2F-Peracetyl-Fucose