1. Metabolic Enzyme/Protease
    Apoptosis
  2. Mitochondrial Metabolism
    Ferroptosis
  3. EPI-743

EPI-743  (Synonyms: α-Tocotrienol quinone; PTC-743; Vatiquinone; NCT04378075)

Cat. No.: HY-16772 Purity: 98.38%
COA Handling Instructions

EPI-743 (Vatiquinone; α-Tocotrienol quinone; PTC-743; NCT04378075) is a potent cellular oxidative stress protectant, inhibits ferroptosis in cells, which could be used for the study for mitochondrial diseases. EPI-743 is a synthetic analog of vitamin E with oral activity, targets repletion of reduced intracellular glutathione.

For research use only. We do not sell to patients.

EPI-743 Chemical Structure

EPI-743 Chemical Structure

CAS No. : 1213269-98-7

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5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 250 In-stock
Estimated Time of Arrival: December 31
25 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 950 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

EPI-743 (Vatiquinone; α-Tocotrienol quinone; PTC-743; NCT04378075) is a potent cellular oxidative stress protectant, inhibits ferroptosis in cells, which could be used for the study for mitochondrial diseases. EPI-743 is a synthetic analog of vitamin E with oral activity, targets repletion of reduced intracellular glutathione[1][2].

IC50 & Target

Mitochondria[1].

In Vitro

Ferroptosis is a form of iron- and lipid-dependent regulated cell death associated with glutathione depletion and production of lipid peroxides by lipoxygenase enzymes.
EPI-743 prevents RSL3-induced ferroptosis in PCH6 patient fibroblasts with mean EC50 potency values of 17.3-21.8 nM[3].
EPI-743 (37, 111, 333 nM; 24 h) exhibits prevention of BODIPY 581/591 C11 lipid oxidation[3].
EPI-743 (0.1 nM-1 mM; 48 h) potently prevents ferroptosis induced by RSL3 (2 μM), FeC (100 μM), BSO (50 μM)[3].
EPI-743 (1 μM, 3 h) is reduced to EPI-743 hydroquinone (EPI-743-HQ) in PCH6 patient fibroblasts, and EPI-743-HQ (0.1-100 μM; 30 min) inhibits human 15-LO enzyme activity with 20% inhibition at 100 μM, and IC50 is 4.4 μM[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: Primary fibroblasts and B-lymphocytes
Concentration: 0-1 mM
Incubation Time: 48 hours
Result: Inhibited RSL3-mediated ferroptotic cell death in B-lymphocytes in a dose-dependent manner.
Restored viability to levels comparable with untreated cells, indicating complete rescue.
Clinical Trial
Molecular Weight

440.66

Formula

C29H44O3

CAS No.
SMILES

O=C1C(CC[[email protected]](C)(O)CC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)=C(C)C(C(C)=C1C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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EPI-743
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