CGS 24891
CGS 24891 is an orally active 5-lipoxygenase (5-LO) inhibitor, with an IC50 value of 0.051 μM in guinea pigs and 0.11 μM in dogs. CGS 24891 inhibits the production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) from arachidonic acid. CGS 24891 weakly inhibits 12-lipoxygenase (12-LO) with an IC50 of 0.41 μM. CGS 24891 is applicable to research on inflammation and allergic reactions.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 134823-10-2
- Formel: C18H17FN2O4
- Molecular Weight:344.34
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
Biologische Aktivität
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5-LO 0.051 (gui μM (IC50) |
5-LO 0.11 (dogs μM (IC50) |
12-LOX 0.41 μM (IC50) |
CGS 24891 potently inhibits 5-lipoxygenase activity in guinea pig polymorphonuclear leukocytes (PMNs) with an IC50 value of 51 nM[1].
CGS 24891 inhibits the activity of 5-lipoxygenase in canine whole blood, with an IC50 of 0.11 μM[1].
CGS 24891 inhibits 12-lipoxygenase activity in platelets with an IC50 of 0.41 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 134823-10-2
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Molecular Weight 344.34
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Formel C18H17FN2O4
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SMILES
O=C(N(CC1=CC2=C(OC1)C=CC(OC3=CC=C(C=C3)F)=C2)O)NC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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