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Art. -Nr.: HY-P11752

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Cyclo(KLARLLT)

Cyclo (KLARLLT) is an EGFR ligand with a K_d value of 1.16 μM. Cyclo (KLARLLT) binds to domain I of EGFR and interacts with both the open and closed conformations of EGFR. Cyclo (KLARLLT) is a modified variant of LARLLT (HY-P11078). Cyclo (KLARLLT) can be used in the research of colorectal cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₃₇H₆₉N₁₁O₈
Molecular Weight:796.01

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Kundenspezifische Peptidsynthese

Cyclo(KLARLLT) Chemical Structure

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
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Calculators
Help & FAQs
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Bioz

Biologische Aktivität

Beschreibung

Alle EGFR Isoform-spezifische Produkte anzeigen :

In Vitro

Cyclo (KLARLLT) (0-200 μM) binds to the purified extracellular domain of EGFR, with a K_D value of 1.16 μM^[1].
Cyclo (KLARLLT) binds to domain I of EGFR (including both open and closed conformations), and its low-energy structure is stabilized by hydrogen bonds and hydrophobic interactions^[1].
Cyclo (KLARLLT) (2 mg/mL; 0-48 h at 37°C) exhibits significantly improved stability in human serum compared with its linear analog KLARLLT; nearly 60% of the peptide remains intact after incubation at 37°C for 48 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 796.01
Formel C₃₇H₆₉N₁₁O₈
Sequence

Cyclo(Lys-Leu-Ala-Arg-Leu-Leu-Thr)
Sequence Shortening

Cyclo(KLARLLT)
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Williams TM, et al. Peptide ligands for targeting the extracellular domain of EGFR: Comparison between linear and cyclic peptides. Chem Biol Drug Des. 2018;91(2):605-619. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
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- In Vitro
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Cyclo(KLARLLT)

Alle EGFR Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Cyclo(KLARLLT) Related Classifications

HY-P11752 Related Classifications