CEP68 - centrosomal protein 68 Gene

Also Known as KIAA0582

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23177

About CEP68

Cytogenetic location: 2p14 Genomic coordinates (GRCh38): 2:65,056,416-65,087,004 (from NCBI)

This gene has 31 transcripts (splice variants), 192 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 8.3), ovary (RPKM 8.1) and 25 other tissues.

Summary

Enables protein domain specific binding activity and protein kinase binding activity. Involved in centriole-centriole cohesion and protein localization to organelle. Located in several cellular components, including centriolar satellite; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CEP68 Products (4)

mRNA Protein Name
NM_001319100.2 NP_001306029.1 centrosomal protein of 68 kDa isoform a
NM_001319101.2 NP_001306030.1 centrosomal protein of 68 kDa isoform b
NM_001410838.1 NP_001397767.1 centrosomal protein of 68 kDa isoform c
NM_015147.3 NP_055962.2 centrosomal protein of 68 kDa isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
24554434 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
24554434 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in centriole-centriole cohesion IMP
IMP: Inferred from mutant phenotype
24554434 GOA
involved in centrosome cycle IMP
IMP: Inferred from mutant phenotype
18042621 GOA
involved in protein localization to organelle IMP
IMP: Inferred from mutant phenotype
24554434 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in centrosome IDA
IDA: Inferred from direct assay
18042621 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

centrosomal protein of 68 kDa

  • centrosomal protein 68kDa

CEP68 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
CEP68 Q76N32 CTBP1 Homo sapiens Q13363-2
Validated Y2H
25416956
Intra
CEP68 Q76N32 BTRC Homo sapiens Q9Y297
Anti Tag CoIP
25503564
Intra
CEP68 Q76N32 CDK5RAP2 Homo sapiens Q96SN8
Anti Bait CoIP
25503564
Intra
CEP68 Q76N32 CDK5RAP2 Homo sapiens Q96SN8
Anti Tag CoIP
25503564
Intra
CEP68 Q76N32 PLK1 Homo sapiens P53350
Protein Kinase Assay
25503564
Intra
CEP68 Q76N32 PLK1 Homo sapiens P53350
Anti Tag CoIP
25503564
Intra
CEP68 Q76N32 PCNT Homo sapiens O95613
Anti Tag CoIP
25503564
Intra
CEP68 Q76N32 USHBP1 Homo sapiens Q8N6Y0
Validated Y2H
25416956
Intra
CEP68 Q76N32 USHBP1 Homo sapiens Q8N6Y0
Y2H Array
25416956
Intra
CEP68 Q76N32 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS02520 CEP68 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03197 CRTAC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CEP68 MGD MGI:2667663
Bos taurus CEP68 VGNC VGNC:27210
Felis catus CEP68 VGNC VGNC:60780
Macaca mulatta CEP68 VGNC VGNC:71127
Canis familiaris CEP68 VGNC VGNC:39134
Rattus norvegicus CEP68 RGD RGD:1309101
Others CEP68 NCBI