PILRA - paired immunoglobin like type 2 receptor alpha Gene

Also Known as FDF03

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 29992

About PILRA

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,371,291-100,400,096 (from NCBI)

This gene has 7 transcripts (splice variants), 27 orthologues and 1 paralogue. Broad expression in appendix (RPKM 17.4), spleen (RPKM 11.8) and 23 other tissues.

Summary

Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. [provided by RefSeq, Jul 2008]

PILRA Products (3)

mRNA	Protein	Name
NM_013439.3	NP_038467.2	paired immunoglobulin-like type 2 receptor alpha isoform 1 precursor
NM_178272.2	NP_840056.1	paired immunoglobulin-like type 2 receptor alpha isoform 2 precursor
NM_178273.2	NP_840057.1	paired immunoglobulin-like type 2 receptor alpha isoform 3 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10660620	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
acts upstream of or within signal transduction	IDA IDA: Inferred from direct assay	10903717	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PILRA Protein Structure

V-set

0
100
200
303 a.a.

Protein Preferred Names	Protein Names
paired immunoglobulin-like type 2 receptor alpha	cell surface receptor FDF03

PILRA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	PILRA	Q9UKJ1	NPDC1	Homo sapiens	Q9NQX5	SPR	30388101
Intra	PILRA	Q9UKJ1	NPDC1	Homo sapiens	Q9NQX5	FACS	30388101
Intra	PILRA	Q9UKJ1	PTPN6	Homo sapiens	P29350	Anti Tag CoIP	10660620
Intra	PILRA	Q9UKJ1	PTPN6	Homo sapiens	P29350	SPR	10660620
Cross	PILRA	Q9UKJ1	gB	Human herpesvirus 1	P06436	Anti Bait CoIP	18358807
Cross	PILRA	Q9UKJ1	gB	Human herpesvirus 1	P06436	FACS	18358807

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PILRA Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P77140	PILR-alpha Protein, Human (HEK293)	AAH17812 (Q20-D226)	≥ 85%, as determined by reducing SDS-PAGE.
HY-P77141	PILR-alpha Protein, Human (HEK293, Fc)	AAH17812 (Q20-D226)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77142	PILR-alpha Protein, Human (178a.a, HEK293, His)	Q9UKJ1-1 (Q20-A197)	≥ 95%, as determined by reducing Tris-Bis PAGE.
HY-P78022	PILR-alpha Protein, Human (178a.a, HEK293, Fc)	Q9UKJ1-1 (Q20-A197)	≥ 95%, as determined by Bis-Tris PAGE.

Related Diseases

Diseases	Alias
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos
Inflammatory Bowel Disease 25	Early Onset Autosomal Recessive Inflammatory Bowel Disease 25 Ibd25 Inflammatory Bowel Disease 25, Autosomal Recessive
Spermatogenic Failure, Y-Linked, 2	SPGFY2 Spermatogenic Failure, Nonobstructive, Y-Linked Y-Linked Spermatogenic Failure 2 Azoospermia, Nonobstructive, Y-Linked Oligozoospermia, Nonobstructive, Y-Linked Oligospermia, Nonobstructive, Y-Linked Spermatogenic Arrest, Y-Linked Nonobstructive Y-Linked Spermatogenic Failure Spermatogenic Failure Y-Linked 2 Azoospermia Non-Obstructive Y-Linked Non-Obstructive Azoospermia And Infertility Oligospermia Non-Obstructive Y-Linked Oligozoospermia Non-Obstructive Y-Linked Spermatogenic Arrest Y-Linked Spermatogenic Failure Nonobstructive Y-Linked

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS10545	PILRA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20082	Pilra Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26585	Pilra Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-P992290	Anti-PILRA Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PILRA	RGD	RGD:6497409
Mus musculus	PILRA	MGD	MGI:2450529
Others	PILRA	NCBI