Cacna1s - calcium voltage-gated channel subunit alpha1 S Gene

Also Known as Cchl1a3; RGD1565743

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 682930

Summary

Enables high voltage-gated Calcium Channel activity. Involved in calcium ion transport. Located in dendritic spine head and sarcolemma. Part of voltage-gated Calcium Channel complex. Human ortholog(s) of this gene implicated in hypokalemic periodic paralysis and malignant hyperthermia. Orthologous to human CACNA1S (calcium voltage-gated channel subunit alpha1 S). [provided by Alliance of Genome Resources, Apr 2022]

Cacna1s Products (1)

mRNA Protein Name
NM_053873.1 NP_446325.1 voltage-dependent L-type calcium channel subunit alpha-1S

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables high voltage-gated calcium channel activity IDA
IDA: Inferred from direct assay
7479909 RGD
enables voltage-gated calcium channel activity IDA
IDA: Inferred from direct assay
20101487 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in calcium ion transport IDA
IDA: Inferred from direct assay
7479909 RGD
involved in response to caloric restriction IEP
IEP: Inferred from expression pattern
9742952 RGD
Cellular Component GO Annotation Evidence Verweise Source
located in dendritic spine head IDA
IDA: Inferred from direct assay
24519419 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
21474431 RGD
part of voltage-gated calcium channel complex IDA
IDA: Inferred from direct assay
7479909 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

voltage-dependent L-type calcium channel subunit alpha-1S

  • ROB1

  • calcium channel, voltage-dependent, L type, alpha 1S subunit

  • voltage-gated calcium channel subunit alpha Cav1.1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS01800 CACNA1S Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21234 Cacna1s Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27751 Cacna1s Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cacna1s NCBI NCBI:779