Scn9a - sodium voltage-gated channel alpha subunit 9 Gene

Also Known as PN1; Scn2a; Nav1.7

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 78956

About Scn9a

Primary_assembly 3: 51,145,146-51,293,516 reverse strand.mRatBN7.2:CM026976.1

This gene has 1 transcript (splice variant), 111 orthologues, 26 paralogues and is associated with 44 phenotypes. Biased expression in Brain (RPKM 67.9), Adrenal (RPKM 18.) and 3 other tissues.

Summary

Enables sodium ion binding activity and voltage-gated Sodium Channel activity. Involved in several processes, including behavioral response to formalin induced pain; negative regulation of action potential; and neuronal action potential. Located in axon. Part of voltage-gated Sodium Channel complex. Human ortholog(s) of this gene implicated in erythromelalgia; generalized epilepsy with febrile seizures plus 7; and paroxysmal extreme pain disorder. Orthologous to human SCN9A (sodium voltage-gated channel alpha subunit 9). [provided by Alliance of Genome Resources, Apr 2022]

Scn9a Products (1)

mRNA Protein Name
NM_133289.2 NP_579823.1 sodium channel protein type 9 subunit alpha

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Verweise Source
involved in behavioral response to formalin induced pain IMP
IMP: Inferred from mutant phenotype
31550995 RGD
involved in negative regulation of action potential IMP
IMP: Inferred from mutant phenotype
31550995 RGD
Cellular Component GO Annotation Evidence Verweise Source
located in axon IDA
IDA: Inferred from direct assay
21118538 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Scn9a Protein Structure

Ion_trans

Ion_trans: pfam00520 (124 - 409)

Na_trans_cytopl

Na_trans_cytopl: pfam11933 (533 - 692)

Ion_trans

Ion_trans: pfam00520 (741 - 954)

Na_trans_assoc

Na_trans_assoc: pfam06512 (980 - 1184)

Ion_trans

Ion_trans: pfam00520 (1188 - 1463)

Na_channel_gate

Na_channel_gate: cd13433 (1455 - 1507)

Ion_trans

Ion_trans: pfam00520 (1511 - 1767)

IQ

IQ: smart00015 (1885 - 1907)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 1984 a.a.
Protein Preferred Names Protein Names

sodium channel protein type 9 subunit alpha

  • peripheral sodium channel 1

  • sodium channel protein type IX subunit alpha

  • sodium channel, voltage-gated, type 9, alpha polypeptide

  • sodium channel, voltage-gated, type IX, alpha subunit

  • voltage-gated sodium channel subunit alpha Nav1.7

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS12548 SCN9A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12549 Scn9a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12550 Scn9a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P990503 Anti-SCN9a/Nav1.7 Antibody Inhibitor 98.57% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Scn9a NCBI NCBI:6335