ANP32A - acidic nuclear phosphoprotein 32 family member A Gene

Also Known as LANP; MAPM; PP32; HPPCn; PHAP1; PHAPI; I1PP2A; C15orf1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8125

About ANP32A

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:68,778,535-68,820,895 (from NCBI)

This gene has 11 transcripts (splice variants), 217 orthologues and 3 paralogues. Ubiquitous expression in lymph node (RPKM 45.8), bone marrow (RPKM 40.5) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in nucleocytoplasmic transport. Located in endoplasmic reticulum; nucleus; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ANP32A Products (1)

mRNA Protein Name
NM_006305.4 NP_006296.1 acidic leucine-rich nuclear phosphoprotein 32 family member A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
16169070 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in nucleocytoplasmic transport IDA
IDA: Inferred from direct assay
11729309 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11729309 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
11555662 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11555662 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
11555662 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANP32A Protein Structure

LRR_9

LRR_9: Leucine-rich repeat (49 - 154)

  • 0
  • 100
  • 200
  • 249 a.a.
Protein Preferred Names Protein Names

acidic leucine-rich nuclear phosphoprotein 32 family member A

  • acidic (leucine-rich) nuclear phosphoprotein 32 family, member A

ANP32A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
ANP32A P39687 E4F1 Homo sapiens Q66K89
Imaging
17557114
Intra
ANP32A P39687 PPP2CA Homo sapiens P67775
Anti Tag CoIP
21806989
Intra
ANP32A P39687 ATXN1 Homo sapiens P54253
Validated Y2H
32814053
Intra
ANP32A P39687 ATXN1 Homo sapiens P54253
Y2H Array
32814053
Intra
ANP32A P39687 ATXN1 Homo sapiens P54253
Y2H Pooling
32814053
Cross
ANP32A P39687 Ppp2ca Rattus norvegicus P63331
Pull Down
21806989
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ANP32A Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P76150 ANP32A Protein, Human (His) P39687 (E2-K238) ≥ 95%, as determined by reducing SDS-PAGE.

ANP32A Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P85036 ANP32A Antibody WB, IHC-P Human

Related Diseases

Diseases Alias
Spinocerebellar Ataxia 1

  • Spinocerebellar Ataxia Type 1

  • SCA1

  • Olivopontocerebellar Atrophy I

  • Opca1

  • Opca4

  • Menzel Type Opca

  • Schut-Haymaker Type Opca

  • Spinocerebellar Atrophy I

  • Opca I

  • Olivopontocerebellar Atrophy Iv

  • Opca Iv

  • Cerebelloparenchymal Disorder I

  • Cpd1

  • Olivopontocerebellar Atrophy 1

  • Cerebelloparenchymal Disorder 1

  • Olivopontocerebellar Atrophy 4

  • Spinocerebellar Atrophy 1

  • Type 1 Spinocerebellar Ataxia

  • Spinocerebellar Ataxia-1

  • Ataxia, Spinocerebellar, Type 1
Influenza

  • Flu

  • Influenza With Non-Respiratory Manifestation

  • Influenza With Other Manifestations

  • Influenza, Human

  • Influenza, Susceptibility To

  • Seasonal Influenza, Virus Identified
Primary Cerebellar Degeneration

  • Spinocerebellar Degenerations

  • Cerebellar Degenerations, Primary

  • Spinocerebellar Degeneration
Avian Influenza

  • Bird Flu

  • Influenza In Birds

  • Avian Flu
Lung Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of Lung

  • Squamous Cell Lung Carcinoma

  • Epidermoid Cell Carcinoma Of The Lung

  • Squamous Cell Lung Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS00751 ANP32A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21091 Anp32a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27609 Anp32a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ANP32A RGD RGD:11508551
Mus musculus ANP32A MGD MGI:108447
Macaca mulatta ANP32A VGNC VGNC:84302
Others ANP32A NCBI