Pebezertinib
Based on 1 Customer Validation
Pebezertinib (BLU 451) is an orally active inhibitor for EGFR. Pebezertinib exhibits the ability to penetrate the central nervous system (CNS). Pebezertinib can be used for research about non-small cell lung cancer carrying EGFR exon 20 insertion.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.56%
- CAS. Nr.: 2769954-39-2
- Formel: C24H19F4N7O
- Molecular Weight:497.45
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Chemical Information
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Alle EGFR Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 2769954-39-2
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Appearance Solid
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Molecular Weight 497.45
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Formel C24H19F4N7O
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Color White to off-white
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SMILES
O=C(NC1=CC=C(C(NC2=C(C3=CC=C(C(F)(F)F)C=C3)C=NC(NC4=CN(C)N=C4)=N2)=C1)F)C=C
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Synonyms
BLU 451; LNG-451
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 116.67 mg/mL (234.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0103 mL | 10.0513 mL | 20.1025 mL | 50.2563 mL |
| 5 mM | 0.4021 mL | 2.0103 mL | 4.0205 mL | 10.0513 mL | |
| 10 mM | 0.2010 mL | 1.0051 mL | 2.0103 mL | 5.0256 mL | |
| 15 mM | 0.1340 mL | 0.6701 mL | 1.3402 mL | 3.3504 mL | |
| 20 mM | 0.1005 mL | 0.5026 mL | 1.0051 mL | 2.5128 mL | |
| 25 mM | 0.0804 mL | 0.4021 mL | 0.8041 mL | 2.0103 mL | |
| 30 mM | 0.0670 mL | 0.3350 mL | 0.6701 mL | 1.6752 mL | |
| 40 mM | 0.0503 mL | 0.2513 mL | 0.5026 mL | 1.2564 mL | |
| 50 mM | 0.0402 mL | 0.2010 mL | 0.4021 mL | 1.0051 mL | |
| 60 mM | 0.0335 mL | 0.1675 mL | 0.3350 mL | 0.8376 mL | |
| 80 mM | 0.0251 mL | 0.1256 mL | 0.2513 mL | 0.6282 mL | |
| 100 mM | 0.0201 mL | 0.1005 mL | 0.2010 mL | 0.5026 mL |
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