BChE-IN-48
BChE-IN-48 (Compound 12a) is a BChE inhibitor that can cross the blood-brain barrier with IC50 values for eqBChE and huBChE of 1.3 and 0.95 μM respectively. BChE-IN-48 exhibits an IC50 value for eeAChE of 8.6 μM. BChE-IN-48 exhibits significant neuroprotective activity in cell damage and significantly improves cognitive impairment in mouse models. BChE-IN-48 can be used for research on Alzheimer's disease.
For research use only. We do not sell to patients.
- Formula: C25H32N2O4
- Molecular Weight:424.53
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
hBCHE 0.95 μM (IC50) |
eqBCHE 1.3 μM (IC50) |
eel AChE 8.6 μM (IC50) |
Chemical Information
-
Molecular Weight 424.53
-
Formula C25H32N2O4
-
SMILES
COC1=C(OC(N(C)C)=O)C=CC(CCC(N2CCC(CC3=CC=CC=C3)CC2)=O)=C1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz