GPLD1 - glycosylphosphatidylinositol specific phospholipase D1 Gene

Also Known as PLD; GPIPLD; PIGPLD; GPIPLDM; PIGPLD1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2822

About GPLD1

Cytogenetic location: 6p22.3 Genomic coordinates (GRCh38): 6:24,423,969-24,495,287 (from NCBI)

This gene has 6 transcripts (splice variants) and 126 orthologues. Biased expression in liver (RPKM 12.6), skin (RPKM 4.0) and 8 other tissues.

Summary

Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific Phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane. [provided by RefSeq, Jul 2008]

GPLD1 Products (1)

mRNA Protein Name
NM_001503.4 NP_001494.2 phosphatidylinositol-glycan-specific phospholipase D precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glycosylphosphatidylinositol phospholipase D activity IDA
IDA: Inferred from direct assay
1833386 GOA
enables phospholipase D activity IDA
IDA: Inferred from direct assay
2760042 GOA
Biological Process GO Annotation Evidence References Source
involved in GPI anchor release IDA
IDA: Inferred from direct assay
2760042 GOA
involved in GPI anchor release IMP
IMP: Inferred from mutant phenotype
17720976 GOA
involved in cell migration involved in sprouting angiogenesis IMP
IMP: Inferred from mutant phenotype
17720976 GOA
involved in cellular response to calcium ion IDA
IDA: Inferred from direct assay
2760042 GOA
involved in cellular response to cholesterol IMP
IMP: Inferred from mutant phenotype
17761367 GOA
involved in cellular response to insulin stimulus IDA
IDA: Inferred from direct assay
15907827 GOA
involved in cellular response to pH IDA
IDA: Inferred from direct assay
17761367 GOA
involved in cellular response to triglyceride IMP
IMP: Inferred from mutant phenotype
17761367 GOA
involved in cellular response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
17761367 GOA
involved in complement receptor mediated signaling pathway IDA
IDA: Inferred from direct assay
15907827 GOA
involved in insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
18328347 GOA
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
19135435 GOA
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
19135435 GOA
involved in positive regulation of endothelial cell migration IMP
IMP: Inferred from mutant phenotype
17720976 GOA
involved in positive regulation of membrane protein ectodomain proteolysis IDA
IDA: Inferred from direct assay
17720976 GOA
involved in regulation of cellular response to insulin stimulus IDA
IDA: Inferred from direct assay
18328347 GOA
involved in response to glucose IDA
IDA: Inferred from direct assay
15907827 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19135435 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
1833386 GOA
located in intracellular membrane-bounded organelle IDA
IDA: Inferred from direct assay
1833386 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPLD1 Protein Structure

Zn_dep_PLPC

Zn_dep_PLPC: Zinc dependent phospholipase C (28 - 187)

FG-GAP

FG-GAP: FG-GAP repeat (382 - 417)

FG-GAP

FG-GAP: FG-GAP repeat (450 - 488)

FG-GAP

FG-GAP: FG-GAP repeat (514 - 547)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 840 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol-glycan-specific phospholipase D

  • GPI-PLD

Related Diseases

Diseases Alias
Succinic Semialdehyde Dehydrogenase Deficiency

  • 4-Hydroxybutyric Aciduria

  • Ssadh Deficiency

  • Gamma-Hydroxybutyric Aciduria

  • Gaba Metabolic Defect

  • SSADHD

  • Ssadh

  • Succinate-Semialdehyde Dehydrogenase Deficiency

  • Gamma-Hydroxybutyricaciduria

  • 4-Hydroxybutyricaciduria

  • Gamma-Hydroxybutyric Acidemia

  • Succinate Semialdehyde Dehydrogenase Deficiency
Glandular Tularemia
Typhoidal Tularemia
Brill-Zinsser Disease

  • Recrudescent Typhus

  • Brill Disease

  • Brill Zinsser Disease

  • Brill'S Disease

  • Latent Typhus

  • Sporadic Typhus

  • Typhus, Epidemic Louse-Borne

  • Recrudescent Typhus Due To Rickettsia Prowazekii

  • Recrudescent Typhus Fever

  • Recrudescent Brill-Zinsser Typhus Due To Rickettsia Prowazekii

  • Recrudescent Brill Disease

  • Recrudescent Typhus Fever Due To Rickettsia Prowazekii
Oculoglandular Tularemia
Epidemic Typhus

  • Typhus

  • Typhus Fever

  • Epidemic Louse-Borne Typhus Fever Due To Rickettsia Prowazekii

  • Murine Typhus

  • Classical Typhus

  • Endemic Flea-Borne Typhus

  • Endemic Typhus Fever

  • Epidemic Louse-Borne Typhus

  • Famine Fever

  • Flea-Borne Typhus

  • Jail Fever

  • Louse-Borne Typhus

  • Mexican Typhus

  • Shop Typhus

  • Urban Typhus

  • Brill-Zinsser Disease

  • Endemic Typhus

  • Sylvatic Typhus

  • Epidemic Typhus

  • European Typhus

  • Exanthematic Typhus Fever

  • Exanthematous Typhus

  • Flea Typhus

  • Flea-Borne Rickettsiosis

  • Hospital Fever

  • Louse-Borne [Epidemic] Typhus

  • Louse-Borne Rickettsiosis

  • Moscow Typhus

  • Murine [Endemic] Typhus

  • Petechial Fever

  • Prison Fever

  • Rat Flea Typhus

  • Ship Fever

  • Typhus Exanthematique

  • Typhus, Endemic Flea-Borne

  • Typhus, Epidemic Louse-Borne

  • Typhus Group Rickettsial Disease

  • Relapsing Fever

  • Typhus Fever Nos

  • Typhus Nos

  • Epidemic Typhus Fever

  • Louse-Borne Typhus Fever

  • Classical Typhus Fever

  • Louse-Borne Tabardillo

  • Epidemic Typhus Fever Due To Rickettsia Prowazekii

  • Endemic Murine Typhus

  • Flea-Borne Typhus Fever

  • Murine Endemic Flea Typhus

  • Rat Typhus

  • Typhus Due To Rickettsia Typhi

  • Flea-Borne Tabardillo

  • Rickettsia Typhi Rickettsiosis

  • Mexican Fever

  • Murine Flea-Borne Typhus

  • Mooser Bodies

  • Tsutsugamushi Fever

  • Kedani Fever

  • Mite-Borne Typhus

  • Mite-Borne Typhus Due To Rickettsia Tsutsugamushi

  • Scrub Typhus

  • Tsutsugamushi

  • Tsutsugamushi Disease

  • Scrub Mite-Borne Typhus

  • Sumatran Mite Fever

  • Japanese River Fever

  • Kedani Typhus

  • Rickettsia Tsutsugamushi Rickettsiosis

  • Sumatran Mite Typhus

  • Tropical Typhus

  • Japanese Typhus
African Tick-Bite Fever

  • Rickettsia Africae Spotted Fever

  • South African Tick-Bite Fever

  • African Tick Bite Fever
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05642 GPLD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20415 Gpld1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26924 Gpld1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GPLD1 VGNC VGNC:67410
Macaca mulatta GPLD1 VGNC VGNC:73120
Bos taurus GPLD1 VGNC VGNC:29536
Mus musculus GPLD1 MGD MGI:106604
Rattus norvegicus GPLD1 RGD RGD:631371
Canis familiaris GPLD1 VGNC VGNC:41384
Others GPLD1 NCBI